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Home Oxazoles 1434639-57-2
1434639-57-2,MFCD30802583
Catalog No.:AA003ARV

1434639-57-2 | 1,4-Dihydro-1-[(2R)-2-(2-methoxyphenyl)-2-[(tetrahydro-2H-pyran-4-yl)oxy]ethyl]-α,α,5-trimethyl-6-(2-oxazolyl)-2,4-dioxothieno[2,3-d]pyrimidine-3(2H)-acetamide

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$88.00   $61.00
- +
5mg
98%
in stock  
$236.00   $165.00
- +
25mg
98%
in stock  
$677.00   $474.00
- +
50mg
98%
in stock  
$1,109.00   $777.00
- +
100mg
98%
in stock  
$1,843.00   $1,290.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA003ARV
Chemical Name:
1,4-Dihydro-1-[(2R)-2-(2-methoxyphenyl)-2-[(tetrahydro-2H-pyran-4-yl)oxy]ethyl]-α,α,5-trimethyl-6-(2-oxazolyl)-2,4-dioxothieno[2,3-d]pyrimidine-3(2H)-acetamide
CAS Number:
1434639-57-2
Molecular Formula:
C28H32N4O7S
Molecular Weight:
568.6413
MDL Number:
MFCD30802583
SMILES:
COc1ccccc1[C@H](Cn1c(=O)n(c(=O)c2c1sc(c2C)c1ncco1)C(C(=O)N)(C)C)OC1CCOCC1
Properties
Computed Properties
 
Complexity:
948  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
40  
Hydrogen Bond Acceptor Count:
9  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
9  
XLogP3:
2.6  

Downstream Synthesis Route

[1]Li,En-Qin;Zhao,Wei;Zhang,Chenxi;Qin,Lu-Zhe;Liu,Sheng-Jie;Feng,Zhi-Qi;Wen,Xiaoan;Chen,Cai-Ping[EuropeanJournalofPharmaceuticalSciences,2019,vol.137]

Literature

Title: Svensson RU, et al. Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small-cell lung cancer in preclinical models. Nat Med. 2016 Oct;22(10):1108-1119.

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SDS
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Tags:1434639-57-2 Molecular Formula|1434639-57-2 MDL|1434639-57-2 SMILES|1434639-57-2 1,4-Dihydro-1-[(2R)-2-(2-methoxyphenyl)-2-[(tetrahydro-2H-pyran-4-yl)oxy]ethyl]-α,α,5-trimethyl-6-(2-oxazolyl)-2,4-dioxothieno[2,3-d]pyrimidine-3(2H)-acetamide