143492-38-0,MFCD01076527
Catalog No.:AA009AJ3

143492-38-0 | D-ERYTHRO-MAPP

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  • Technical Information
  • Properties
  • Literature
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Technical Information
Catalog Number:
AA009AJ3
Chemical Name:
D-ERYTHRO-MAPP
CAS Number:
143492-38-0
Molecular Formula:
C23H39NO2
Molecular Weight:
361.5613
MDL Number:
MFCD01076527
SMILES:
CCCCCCCCCCCCCC(=O)N[C@@H]([C@H](c1ccccc1)O)C
Properties
Computed Properties
 
Complexity:
339  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
26  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0  
Rotatable Bond Count:
15  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
7.1  

Literature

Title: Novel amide- and sulfonamide-based aromatic ethanolamines: effects of various substituents on the inhibition of acid and neutral ceramidases.

Journal: Bioorganic & medicinal chemistry 20121015

Title: Acid ceramidase as a chemotherapeutic target to overcome resistance to the antitumoral effect of choline kinase α inhibition.

Journal: Current cancer drug targets 20120701

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Ceramide-induced cell death/survival in murine osteoblasts.

Journal: The Journal of endocrinology 20100801

Title: Antagonism of human adiponectin receptors and their membrane progesterone receptor paralogs by TNFalpha and a ceramidase inhibitor.

Journal: Biochemistry 20090623

Title: Novel analogs of D-e-MAPP and B13. Part 1: synthesis and evaluation as potential anticancer agents.

Journal: Bioorganic & medicinal chemistry 20080115

Title: Novel analogs of D-e-MAPP and B13. Part 2: signature effects on bioactive sphingolipids.

Journal: Bioorganic & medicinal chemistry 20080115

Title: De novo C16- and C24-ceramide generation contributes to spontaneous neutrophil apoptosis.

Journal: Journal of leukocyte biology 20070601

Title: Ceramide synthesis correlates with the posttranscriptional regulation of the sterol-regulatory element-binding protein.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20040501

Title: Overcoming resistance to gamma-rays in squamous carcinoma cells by poly-drug elevation of ceramide levels.

Journal: Oncogene 20040408

Title: Neutral ceramidase gene: role in regulating ceramide-induced apoptosis.

Journal: Gene 20031002

Title: Sphingomyelinase amplifies BMP-4-induced osteocalcin synthesis in osteoblasts: role of ceramide.

Journal: Cellular signalling 20021201

Title: Increasing endogenous ceramide using inhibitors of sphingolipid metabolism maximizes ionizing radiation-induced mitochondrial injury and apoptotic cell killing.

Journal: International journal of cancer 20021020

Title: Bcl-2 overexpression prevents apoptosis induced by ceramidase inhibitors in malignant melanoma and HaCaT keratinocytes.

Journal: FEBS letters 20020410

Title: Induction of apoptotic cell death and prevention of tumor growth by ceramide analogues in metastatic human colon cancer.

Journal: Cancer research 20010201

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SDS
Tags:143492-38-0 Molecular Formula|143492-38-0 MDL|143492-38-0 SMILES|143492-38-0 D-ERYTHRO-MAPP
Catalog No.: AA009AJ3
143492-38-0,MFCD01076527
143492-38-0 | D-ERYTHRO-MAPP
This product is typically in stock,please click "Inquire" below or contact us at [email protected]for pricing and availability information.
Inquire
Technical Information
Catalog Number: AA009AJ3
Chemical Name: D-ERYTHRO-MAPP
CAS Number: 143492-38-0
Molecular Formula: C23H39NO2
Molecular Weight: 361.5613
MDL Number: MFCD01076527
SMILES: CCCCCCCCCCCCCC(=O)N[C@@H]([C@H](c1ccccc1)O)C
Properties
Complexity: 339  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 2  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 26  
Hydrogen Bond Acceptor Count: 2  
Hydrogen Bond Donor Count: 2  
Isotope Atom Count: 0  
Rotatable Bond Count: 15  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 7.1  
Literature fold

Title: Novel amide- and sulfonamide-based aromatic ethanolamines: effects of various substituents on the inhibition of acid and neutral ceramidases.

Journal: Bioorganic & medicinal chemistry20121015

Title: Acid ceramidase as a chemotherapeutic target to overcome resistance to the antitumoral effect of choline kinase α inhibition.

Journal: Current cancer drug targets20120701

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters20101101

Title: Ceramide-induced cell death/survival in murine osteoblasts.

Journal: The Journal of endocrinology20100801

Title: Antagonism of human adiponectin receptors and their membrane progesterone receptor paralogs by TNFalpha and a ceramidase inhibitor.

Journal: Biochemistry20090623

Title: Novel analogs of D-e-MAPP and B13. Part 1: synthesis and evaluation as potential anticancer agents.

Journal: Bioorganic & medicinal chemistry20080115

Title: Novel analogs of D-e-MAPP and B13. Part 2: signature effects on bioactive sphingolipids.

Journal: Bioorganic & medicinal chemistry20080115

Title: De novo C16- and C24-ceramide generation contributes to spontaneous neutrophil apoptosis.

Journal: Journal of leukocyte biology20070601

Title: Ceramide synthesis correlates with the posttranscriptional regulation of the sterol-regulatory element-binding protein.

Journal: Arteriosclerosis, thrombosis, and vascular biology20040501

Title: Overcoming resistance to gamma-rays in squamous carcinoma cells by poly-drug elevation of ceramide levels.

Journal: Oncogene20040408

Title: Neutral ceramidase gene: role in regulating ceramide-induced apoptosis.

Journal: Gene20031002

Title: Sphingomyelinase amplifies BMP-4-induced osteocalcin synthesis in osteoblasts: role of ceramide.

Journal: Cellular signalling20021201

Title: Increasing endogenous ceramide using inhibitors of sphingolipid metabolism maximizes ionizing radiation-induced mitochondrial injury and apoptotic cell killing.

Journal: International journal of cancer20021020

Title: Bcl-2 overexpression prevents apoptosis induced by ceramidase inhibitors in malignant melanoma and HaCaT keratinocytes.

Journal: FEBS letters20020410

Title: Induction of apoptotic cell death and prevention of tumor growth by ceramide analogues in metastatic human colon cancer.

Journal: Cancer research20010201

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