[1]JournalofOrganicChemistry,1983,vol.48,p.4852-4860
[1]BioorganicandMedicinalChemistry,2010,vol.18,p.3575-3587
[1]BioorganicandMedicinalChemistryLetters,2011,vol.21,p.1554-1558
[1]BioorganicandMedicinalChemistryLetters,2011,vol.21,p.1554-1558
[1]BioorganicandMedicinalChemistryLetters,2011,vol.21,p.1554-1558
Title: Cocrystals of 5-fluorocytosine. I. Coformers with fixed hydrogen-bonding sites.
Journal: Acta crystallographica. Section B, Structural science 20120801
Title: Cocrystals of 5-fluorocytosine. II. Coformers with variable hydrogen-bonding sites.
Journal: Acta crystallographica. Section B, Structural science 20120801
Title: Fluvastatin upregulates endothelial nitric oxide synthase activity via enhancement of its phosphorylation and expression and via an increase in tetrahydrobiopterin in vascular endothelial cells.
Journal: International journal of cardiology 20120405
Title: Correlations between Endothelial Functions and ROS Detection in Diabetic Microvascular Wall: Early and Late Ascorbic Acid Supplementation.
Journal: International journal of vascular medicine 20120101
Title: Decreased tetrahydrobiopterin and disrupted association of Hsp90 with eNOS by hyperglycemia impair myocardial ischemic preconditioning.
Journal: American journal of physiology. Heart and circulatory physiology 20111101
Title: Synthesis, biological, and antitumor activity of a highly potent 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate inhibitor with proton-coupled folate transporter and folate receptor selectivity over the reduced folate carrier that inhibits β-glycinamide ribonucleotide formyltransferase.
Journal: Journal of medicinal chemistry 20111027
Title: Activation of peroxisome proliferator-activated receptor-{delta} enhances regenerative capacity of human endothelial progenitor cells by stimulating biosynthesis of tetrahydrobiopterin.
Journal: Hypertension (Dallas, Tex. : 1979) 20110801
Title: Pseudopolymorphs of 2,6-diaminopyrimidin-4-one and 2-amino-6-methylpyrimidin-4-one: one or two tautomers present in the same crystal.
Journal: Acta crystallographica. Section C, Crystal structure communications 20110501
Title: Substrate-controlled chemoselective synthesis and potent cytotoxic activity of novel 5,6,7-triarylpyrido[2,3-d]pyrimidin-4-one derivatives.
Journal: Bioorganic & medicinal chemistry letters 20110301
Title: Two new polymorphs of 2,6-diaminopyrimidin-4(3H)-one monohydrate.
Journal: Acta crystallographica. Section C, Crystal structure communications 20110101
Title: Validity of urinary monoamine assay sales under the 'spot baseline urinary neurotransmitter testing marketing model'.
Journal: International journal of nephrology and renovascular disease 20110101
Title: 2,6-Diamino-4-oxo-3,4-dihydropyrim-idin-1-ium chloride dihydrate.
Journal: Acta crystallographica. Section E, Structure reports online 20100901
Title: Design, synthesis and evaluation of 2-amino-4-m-bromoanilino-6-arylmethyl-7H-pyrrolo[2,3-d]pyrimidines as tyrosine kinase inhibitors and antiangiogenic agents.
Journal: Bioorganic & medicinal chemistry 20100715
Title: Synthesis and biological activity of N(4)-phenylsubstituted-6-(2,4-dichloro phenylmethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamines as vascular endothelial growth factor receptor-2 inhibitors and antiangiogenic and antitumor agents.
Journal: Bioorganic & medicinal chemistry 20100515
Title: Tetrahydrobiopterin (BH4), a cofactor for nNOS, restores gastric emptying and nNOS expression in female diabetic rats.
Journal: American journal of physiology. Gastrointestinal and liver physiology 20100501
Title: Novel riboswitch ligand analogs as selective inhibitors of guanine-related metabolic pathways.
Journal: PLoS pathogens 20100401
Title: Synthesis and antitumor activity of a novel series of 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate inhibitors of purine biosynthesis with selectivity for high affinity folate receptors and the proton-coupled folate transporter over the reduced folate carrier for cellular entry.
Journal: Journal of medicinal chemistry 20100211
Title: Role of tetrahydrobiopterin in resistance to myocardial ischemia in Brown Norway and Dahl S rats.
Journal: American journal of physiology. Heart and circulatory physiology 20091101
Title: DFT simulations and vibrational analysis of FT-IR and FT-Raman spectra of 2,4-diamino-6-hydroxypyrimidine.
Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20090815
Title: A facile synthetic approach to 7-deazaguanine nucleosides via a Boc protection strategy.
Journal: Organic letters 20090604
Title: Metallothionein abrogates GTP cyclohydrolase I inhibition-induced cardiac contractile and morphological defects: role of mitochondrial biogenesis.
Journal: Hypertension (Dallas, Tex. : 1979) 20090601
Title: Highly diastereoselective domino synthesis of 6-spirosubstituted pyrido[2,3-d]pyrimidine derivatives in water.
Journal: Journal of combinatorial chemistry 20090101
Title: Acute inhibition of guanosine triphosphate cyclohydrolase 1 uncouples endothelial nitric oxide synthase and elevates blood pressure.
Journal: Hypertension (Dallas, Tex. : 1979) 20080901
Title: Three-day tetrahydrobiopterin therapy increases in vivo hepatic NOS activity and reduces portal pressure in CCl4 cirrhotic rats.
Journal: Journal of hepatology 20080801
Title: Effect of decreased levels of intrinsic tetrahydrobiopterin on endothelial function in anesthetized rats.
Journal: Journal of pharmacological sciences 20080501
Title: 2,4-Diamino-6-hydroxypyrimidine (DAHP) suppresses cytokine-induced VCAM-1 expression on the cell surface of human umbilical vein endothelial cells in a BH(4)-independent manner.
Journal: Biochimica et biophysica acta 20080101
Title: Regulation of tetrahydrobiopterin biosynthesis by shear stress.
Journal: Circulation research 20071012
Title: Alu recombination-mediated structural deletions in the chimpanzee genome.
Journal: PLoS genetics 20071001
Title: An efficient route for the synthesis of a new class of pyrido[2,3-d]pyrimidine derivatives.
Journal: Organic & biomolecular chemistry 20070507
Title: C-Reactive protein-induced endothelial microparticle generation in HUVECs is related to BH4-dependent NO formation.
Journal: Journal of vascular research 20070101
Title: Folic acid reverses endothelial dysfunction induced by inhibition of tetrahydrobiopterin biosynthesis.
Journal: European journal of pharmacology 20060120
Title: Neural tube closure depends on nitric oxide synthase activity.
Journal: Journal of neurochemistry 20060101
Title: Estrogen therapy replenishes vascular tetrahydrobiopterin and reduces oxidative stress in ovariectomized rats.
Journal: Menopause (New York, N.Y.) 20060101
Title: Synthesis and antitumor activity of some novel quinazoline derivatives bearing the biologically active thione moiety.
Journal: Arzneimittel-Forschung 20060101
Title: Tetrahydrobiopterin depletion and ubiquitylation of neuronal nitric oxide synthase.
Journal: Brain research. Molecular brain research 20051207
Title: Inhibition of brain GTP cyclohydrolase I and tetrahydrobiopterin attenuates cerebral infarction via reducing inducible NO synthase and peroxynitrite in ischemic stroke.
Journal: Stroke 20051201
Title: Immobilization stress causes increases in tetrahydrobiopterin, dopamine, and neuromelanin and oxidative damage in the nigrostriatal system.
Journal: Journal of neurochemistry 20051001
Title: Crystal structure and luminescence of lanthanide monodentate complexes [Ln(C(4)N(4)H(6)O)(2)(H(2)O)(6)]Cl(3) and [Ln(C(4)N(4)H(6)O)(2)(H(2)O)(3)(NO(3))(3)] (Ln = Tb or Eu).
Journal: Inorganic chemistry 20050613
Title: Synthesis of classical, three-carbon-bridged 5-substituted furo[2,3-d]pyrimidine and 6-substituted pyrrolo[2,3-d]pyrimidine analogues as antifolates.
Journal: Journal of medicinal chemistry 20041230
Title: Effect of tetrahydrobiopterin on nitric oxide synthase-containing cells in the rat hippocampus.
Journal: Neuroscience research 20041001
Title: The mechanism of potent GTP cyclohydrolase I inhibition by 2,4-diamino-6-hydroxypyrimidine: requirement of the GTP cyclohydrolase I feedback regulatory protein.
Journal: The Journal of biological chemistry 20040924
Title: A new and efficient synthesis of pyrrolo[2,3-d]pyrimidine anticancer agents: Alimta (LY231514, MTA), homo-Alimta, TNP-351, and some aryl 5-substituted pyrrolo[2,3-d]pyrimidines.
Journal: The Journal of organic chemistry 20031226
Title: Tetrahydrobiopterin, a critical factor in the production and role of nitric oxide in mast cells.
Journal: The Journal of biological chemistry 20031212
Title: Antiangiogenic and antitumor agents. Design, synthesis, and evaluation of novel 2-amino-4-(3-bromoanilino)-6-benzylsubstituted pyrrolo[2,3-d]pyrimidines as inhibitors of receptor tyrosine kinases.
Journal: Bioorganic & medicinal chemistry 20031117
Title: GTP cyclohydrolase 1 inhibition attenuates vasodilation and increases blood pressure in rats.
Journal: American journal of physiology. Heart and circulatory physiology 20031101
Title: Exogenous biopterins requirement for iNOS function in vascular smooth muscle cells.
Journal: Journal of cardiovascular pharmacology 20030801
Title: Kainic acid lesion-induced nigral neuronal death.
Journal: Journal of chemical neuroanatomy 20030801
Title: Interactions of peroxynitrite, tetrahydrobiopterin, ascorbic acid, and thiols: implications for uncoupling endothelial nitric-oxide synthase.
Journal: The Journal of biological chemistry 20030620
Title: Tetrahydrobiopterin precursor sepiapterin provides protection against neurotoxicity of 1-methyl-4-phenylpyridinium in nigral slice cultures.
Journal: Journal of neurochemistry 20030401
Title: HMG-CoA reductase inhibitor increases GTP cyclohydrolase I mRNA and tetrahydrobiopterin in vascular endothelial cells.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20030201
Title: Role of tetrahydrobiopterin on ischemia-reperfusion injury in isolated perfused rat hearts.
Journal: The Journal of cardiovascular surgery 20030201
Title: Wavelength-dependent induction of a mycosporine-like amino acid in a rice-field cyanobacterium, Nostoc commune: role of inhibitors and salt stress.
Journal: Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 20030201
Title: Non-classical antifolates, 5-(N-phenylpyrrolidin-3-yl)-2,4,6-triaminopyrimidines and 2,4-Diamino-6(5H)-oxopyrimidines, synthesis and antitumor studies.
Journal: Bioorganic & medicinal chemistry 20030102
Title: Increased vulnerability to ischemia/reperfusion-induced ventricular tachyarrhythmias by pre-ischemic inhibition of nitric oxide synthase in isolated rat hearts.
Journal: Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology 20030101
Title: Lack of nitric oxide mediation of flow-dependent arteriolar dilation in type I diabetes is restored by sepiapterin.
Journal: Journal of vascular research 20030101
Title: Effect of 2,4-diamino-6-hydroxy-pyrimidine on postburn Staphylococcus aureus sepsis in rats.
Journal: Critical care medicine 20021101
Title: Stimulation of tetrahydrobiopterin synthesis by cyclosporin A in mouse brain microvascular endothelial cells.
Journal: The international journal of biochemistry & cell biology 20020901
Title: Tetrahydrobiopterin deficiency increases neuronal vulnerability to hypoxia.
Journal: Journal of neurochemistry 20020901
Title: Possible involvement of tetrahydrobiopterin in the trophic effect of insulin-like growth factor-1 on rat pheochromocytoma-12 (PC12) cells.
Journal: Neuroscience letters 20020809
Title: Glutathione depletion in nigrostriatal slice cultures: GABA loss, dopamine resistance and protection by the tetrahydrobiopterin precursor sepiapterin.
Journal: Brain research 20020510
Title: Cellular basis of endothelial dysfunction in small mesenteric arteries from spontaneously diabetic (db/db -/-) mice: role of decreased tetrahydrobiopterin bioavailability.
Journal: British journal of pharmacology 20020501
Title: 6-[2-(Phosphonomethoxy)alkoxy]pyrimidines with antiviral activity.
Journal: Journal of medicinal chemistry 20020425
Title: Interleukin-1beta-induced nitric oxide production and inhibition of insulin secretion in rat islets of langerhans is dependent upon the nitric oxide synthase cofactor tetrahidrobiopterin.
Journal: Cytokine 20020421
Title: [The protective effects and its underlying mechanism of 2,4-diamino-6-hydroxy-pyrimidine on postburn Staphylococcus aureus sepsis in rats].
Journal: Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns 20020401
Title: 2, 4-diamino-6- hydroxy pyrimidine inhibits NSAIDs induced nitrosyl-complex EPR signals and ulcer in rat jejunum.
Journal: BMC gastroenterology 20020101
Title: A new one-pot three-component condensation reaction for the synthesis of 5-deaza-5,8-dihydropterins.
Journal: Chemical communications (Cambridge, England) 20011207
Title: Involvement of tetrahydrobiopterin in trophic effect of erythropoietin on PC12 cells.
Journal: Biochemical and biophysical research communications 20011130
Title: Carboxy-PTIO increases the tetrahydrobiopterin level in mouse brain microvascular endothelial cells.
Journal: Japanese journal of pharmacology 20010901
Title: Tetrahydrobiopterin augments arginine transport in rat cardiac myocytes through modulation of CAT-2 mRNA.
Journal: The Journal of laboratory and clinical medicine 20010501
Title: Stimulation of tetrahydrobiopterin synthesis induced by insulin: possible involvement of phosphatidylinositol 3-kinase.
Journal: The international journal of biochemistry & cell biology 20010101
Title: Guanosine triphosphate cyclohydrolase I regulates nitric oxide synthesis in renal proximal tubules.
Journal: Journal of the American Society of Nephrology : JASN 19950201
