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143703-25-7,MFCD30182244
Catalog No.:AA01E215

143703-25-7 | CE3F4

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
≥98%
in stock  
$112.00   $78.00
- +
10mg
≥98%
in stock  
$209.00   $146.00
- +
25mg
≥98%(HPLC)
in stock  
$456.00   $319.00
- +
50mg
≥98%(HPLC)
in stock  
$675.00   $473.00
- +
100mg
≥98%(HPLC)
in stock  
$1,047.00   $733.00
- +
  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA01E215
Chemical Name:
CE3F4
CAS Number:
143703-25-7
Molecular Formula:
C11H10Br2FNO
Molecular Weight:
351.0096
MDL Number:
MFCD30182244
SMILES:
O=CN1C(C)CCc2c1cc(Br)c(c2Br)F
Properties
Computed Properties
 
Complexity:
279  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
16  
Hydrogen Bond Acceptor Count:
2  
Undefined Atom Stereocenter Count:
1  
XLogP3:
3.6  

Literature

Title: Courilleau D, et al. The (R)-enantiomer of CE3F4 is a preferential inhibitor of human exchange protein directly activated by cyclic AMP isoform 1 (Epac1). Biochem Biophys Res Commun. 2013 Oct 25;440(3):443-8.

Title: Courilleau D, et al. Identification of a tetrahydroquinoline analog as a pharmacological inhibitor of the cAMP-binding protein Epac. J Biol Chem. 2012 Dec 28;287(53):44192-202.

Title: Pratt EP, et al. Ca2+ influx through L-type Ca2+ channels and Ca2+-induced Ca2+ release regulate cAMP accumulation and Epac1-dependent ERK 1/2 activation in INS-1 cells. Mol Cell Endocrinol. 2016 Jan 5;419:60-71.

Title: Prajapati R, et al. Usefulness of Exchanged Protein Directly Activated by cAMP (Epac)1-Inhibiting Therapy for Prevention of Atrial and Ventricular Arrhythmias in Mice. Circ J. 2019;83(2):295-303.

Title: Abstract 17548: Inhibition of Exchange Protein 1 Directly Activated by cAMP (Epac1) is Cardioprotective Against Ischemia-reperfusion Injury

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Tags:143703-25-7 Molecular Formula|143703-25-7 MDL|143703-25-7 SMILES|143703-25-7 CE3F4