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143797-62-0,MFCD00913519
Catalog No.:AA01ENDW

143797-62-0 | SB 200646 hydrochloride

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1mg
≥98%
in stock  
$46.00   $32.00
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5mg
≥98%
in stock  
$166.00   $116.00
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10mg
≥98%
in stock  
$306.00   $214.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA01ENDW
Chemical Name:
SB 200646 hydrochloride
CAS Number:
143797-62-0
Molecular Formula:
C15H15ClN4O
Molecular Weight:
302.7588
MDL Number:
MFCD00913519
SMILES:
CN1C=CC2=C1C=CC(=C2)NC(=O)NC3=CN=CC=C3.Cl
Properties
Computed Properties
 
Complexity:
349  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
21  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
2  

Downstream Synthesis Route
102308-97-4    4013-72-3   
etherealhydrogenchloride 
  15268-31-2   
N-(1-Methyl-1H-indol-5-yl)-N'-(3-pyridyl)ureahydrochloride 

[1]Patent:US5328922,1994,A

Literature

Title: Effect of combined administration of afobazole and 5-HT2b/2c receptor antagonist SB-200646A on neurochemical profile of brain structures in C57Bl/6 and BALB/c mice.

Journal: Bulletin of experimental biology and medicine 20120901

Title: [Possible role of serotonin 5-HT2 receptors in mechanism of afobazole anxiolytic action: neurochemical study of inter-line differences in mice].

Journal: Eksperimental'naia i klinicheskaia farmakologiia 20110101

Title: Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Journal: Nature chemical biology 20091001

Title: Role of 5-hydroxytryptamine2C receptors in Ca2+-dependent ethanol potentiation of GABA release onto ventral tegmental area dopamine neurons.

Journal: The Journal of pharmacology and experimental therapeutics 20090501

Title: 5-HT(2C) receptor activation is a common mechanism on proerectile effects of apomorphine, oxytocin and melanotan-II in rats.

Journal: European journal of pharmacology 20080728

Title: The acute and chronic administration of the 5-HT(2B/2C) receptor antagonist SB-200646A significantly alters the activity of spontaneously active midbrain dopamine neurons in the rat: An in vivo extracellular single cell study.

Journal: Synapse (New York, N.Y.) 20060615

Title: Blackburn TP, et al. The acute and chronic administration of the 5-HT(2B/2C) receptor antagonist SB-200646A significantly alters the activity of spontaneously active midbrain dopamine neurons in the rat: An in vivo extracellular single cell study. Synapse. 2006 Jun 15;59(8):502-12.

Title: Kennett GA, et al. In vivo properties of SB 200646A, a 5-HT2C/2B receptor antagonist. Br J Pharmacol. 1994 Mar;111(3):797-802.

Title: Theile JW, et al. Role of 5-hydroxytryptamine2C receptors in Ca2+-dependent ethanol potentiation of GABA release onto ventral tegmental area dopamine neurons. J Pharmacol Exp Ther. 2009 May;329(2):625-33.

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SDS
Tags:143797-62-0 Molecular Formula|143797-62-0 MDL|143797-62-0 SMILES|143797-62-0 SB 200646 hydrochloride