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Title: Evaluating the significance of cyclic adenosine monophosphate-mediated signaling in human prostate: a functional and biochemical study.
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Title: Design and synthesis of 3,5-disubstituted-1,2,4-oxadiazoles as potent inhibitors of phosphodiesterase4b2.
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Title: Piclamilast inhibits the pro-apoptotic and anti-proliferative responses of A549 cells exposed to H(2)O(2) via mechanisms involving AP-1 activation.
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Title: Phosphodiesterase 4 inhibition attenuates persistent heart and lung injury by neonatal hyperoxia in rats.
Journal: American journal of physiology. Lung cellular and molecular physiology 20120101
Title: Pharmacological validation of Trypanosoma brucei phosphodiesterases B1 and B2 as druggable targets for African sleeping sickness.
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Title: The differential impact of PDE4 subtypes in human lung fibroblasts on cytokine-induced proliferation and myofibroblast conversion.
Journal: Journal of cellular physiology 20110801
Title: Effects of repeated treatment with phosphodiesterase-4 inhibitors on cAMP signaling, hippocampal cell proliferation, and behavior in the forced-swim test.
Journal: The Journal of pharmacology and experimental therapeutics 20110801
Title: New therapeutic options in the management of COPD - focus on roflumilast.
Journal: International journal of chronic obstructive pulmonary disease 20110101
Title: Cytokine-dependent balance of mitogenic effects in primary human lung fibroblasts related to cyclic AMP signaling and phosphodiesterase 4 inhibition.
Journal: Journal of cellular physiology 20100501
Title: Water-soluble PDE4 inhibitors for the treatment of dry eye.
Journal: Bioorganic & medicinal chemistry letters 20100501
Title: Effects of phosphodiesterase 4 inhibition on bleomycin-induced pulmonary fibrosis in mice.
Journal: BMC pulmonary medicine 20100101
Title: PDE8 regulates rapid Teff cell adhesion and proliferation independent of ICER.
Journal: PloS one 20100101
Title: Sildenafil attenuates pulmonary inflammation and fibrin deposition, mortality and right ventricular hypertrophy in neonatal hyperoxic lung injury.
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Title: ABCD of the phosphodiesterase family: interaction and differential activity in COPD.
Journal: International journal of chronic obstructive pulmonary disease 20081201
Title: Can the anti-inflammatory potential of PDE4 inhibitors be realized: guarded optimism or wishful thinking?
Journal: British journal of pharmacology 20081001
Title: Phosphodiesterase-4 inhibition attenuates pulmonary inflammation in neonatal lung injury.
Journal: The European respiratory journal 20080301
Title: Effects of phosphodiesterase inhibitors on tension induced by norepinephrine and accumulation of cyclic nucleotides in isolated human prostatic tissue.
Journal: Urology 20080301
Title: Effects of phosphodiesterase 4 inhibition on alveolarization and hyperoxia toxicity in newborn rats.
Journal: PloS one 20080101
Title: Treating COPD with PDE 4 inhibitors.
Journal: International journal of chronic obstructive pulmonary disease 20071201
Title: Correlation between emetic effect of phosphodiesterase 4 inhibitors and their occupation of the high-affinity rolipram binding site in Suncus murinus brain.
Journal: European journal of pharmacology 20071114
Title: Inhibition of TGF-beta induced lung fibroblast to myofibroblast conversion by phosphodiesterase inhibiting drugs and activators of soluble guanylyl cyclase.
Journal: European journal of pharmacology 20071015
Title: SAR of a series of 5,6-dihydro-(9H)-pyrazolo[3,4-c]-1,2,4-triazolo[4,3-alpha]pyridines as potent inhibitors of human eosinophil phosphodiesterase.
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Title: Inhibition of phosphodiesterase activity, airway inflammation and hyperresponsiveness by PDE4 inhibitor and glucocorticoid in a murine model of allergic asthma.
Journal: Life sciences 20061026
Title: Effects of ciclamilast, a new PDE 4 PDE4 inhibitor, on airway hyperresponsiveness, PDE4D expression and airway inflammation in a murine model of asthma.
Journal: European journal of pharmacology 20061010
Title: Phosphodiesterase type 4 inhibitors cause proinflammatory effects in vivo.
Journal: The Journal of pharmacology and experimental therapeutics 20061001
Title: Antidepressant-like effects of PDE4 inhibitors mediated by the high-affinity rolipram binding state (HARBS) of the phosphodiesterase-4 enzyme (PDE4) in rats.
Journal: Psychopharmacology 20060601
Title: Inhibition of airway hyperresponsiveness and pulmonary inflammation by roflumilast and other PDE4 inhibitors.
Journal: Pulmonary pharmacology & therapeutics 20060101
Title: Pharmacological inhibition of phosphodiesterase 4 triggers ovulation in follicle-stimulating hormone-primed rats.
Journal: Endocrinology 20050101
Title: Structural basis for the activity of drugs that inhibit phosphodiesterases.
Journal: Structure (London, England : 1993) 20041201
Title: Phosphodiesterase IV inhibition by piclamilast potentiates the cytodifferentiating action of retinoids in myeloid leukemia cells. Cross-talk between the cAMP and the retinoic acid signaling pathways.
Journal: The Journal of biological chemistry 20041001
Title: Selective inhibition of purified human phosphodiesterase 4A expressed in yeast cell GL62 by ciclamilast, piclamilast, and rolipram.
Journal: Acta pharmacologica Sinica 20040901
Title: Differential effect of phosphodiesterase IV inhibitor RP73401 on various inflammatory and immune responses relevent to rheumatoid arthritis.
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Title: [Phosphosdiesterase 4 inhibitors in the treatment of pulmonary diseases].
Journal: Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases 20040101
Title: Effects of piclamilast, a selective phosphodiesterase-4 inhibitor, on oxidative burst of sputum cells from mild asthmatics and stable COPD patients.
Journal: Lung 20040101
Title: Antidepressant-induced increase in high-affinity rolipram binding sites in rat brain: dependence on noradrenergic and serotonergic function.
Journal: The Journal of pharmacology and experimental therapeutics 20031001
Title: VEGF-induced HUVEC migration and proliferation are decreased by PDE2 and PDE4 inhibitors.
Journal: Thrombosis and haemostasis 20030801
Title: [Comparison of piclamilast with ciclamilast in bronchodilating and antiallergic effects].
Journal: Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20030801
Title: Synthesis and biological activities of 1-pyridylisoquinoline and 1-pyridyldihydroisoquinoline derivatives as PDE4 inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20030721
Title: Inhibitor binding to type 4 phosphodiesterase (PDE4) assessed using [3H]piclamilast and [3H]rolipram.
Journal: The Journal of pharmacology and experimental therapeutics 20030501
Title: Essential requirements for substrate binding affinity and selectivity toward human CYP2 family enzymes.
Journal: Archives of biochemistry and biophysics 20030101
Title: Potential role of phosphodiesterase 7 in human T cell function: comparative effects of two phosphodiesterase inhibitors.
Journal: Clinical and experimental immunology 20020601
Title: The selective phosphodiesterase 4 inhibitor RP 73-401 reduced matrix metalloproteinase 9 activity and transforming growth factor-beta release during acute lung injury in mice: the role of the balance between Tumor necrosis factor-alpha and interleukin-10.
Journal: The Journal of pharmacology and experimental therapeutics 20020401
Title: Synthesis and biological evaluation of imidazol-2-one and 2-cyanoiminoimidazole derivatives: novel series of PDE4 inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20020225
Title: Phosphodiesterase isoenzyme families in human osteoarthritis chondrocytes--functional importance of phosphodiesterase 4.
Journal: British journal of pharmacology 20020201
Title: Phthalazine PDE4 inhibitors. Part 3: the synthesis and in vitro evaluation of derivatives with a hydrogen bond acceptor.
Journal: Bioorganic & medicinal chemistry letters 20020107
Title: Is up-regulation of phosphodiesterase 4 activity by PGE2 involved in the desensitization of beta-mimetics in late pregnancy human myometrium?
Journal: The Journal of clinical endocrinology and metabolism 20011101
Title: Anti-TNF-alpha properties of new 9-benzyladenine derivatives with selective phosphodiesterase-4- inhibiting properties.
Journal: Biochemical and biophysical research communications 20011026
Title: Modulation of eotaxin formation and eosinophil migration by selective inhibitors of phosphodiesterase type 4 isoenzyme.
Journal: British journal of pharmacology 20010901
Title: Effects of PDE4 inhibitors on lipopolysaccharide-induced priming of superoxide anion production from human mononuclear cells.
Journal: Mediators of inflammation 20010601
Title: Requirement of additional adenylate cyclase activation for the inhibition of human eosinophil degranulation by phosphodiesterase IV inhibitors.
Journal: European journal of pharmacology 20010406
Title: Anti-inflammatory and immunomodulatory potential of the novel PDE4 inhibitor roflumilast in vitro.
Journal: The Journal of pharmacology and experimental therapeutics 20010401
Title: In vivo efficacy in airway disease models of roflumilast, a novel orally active PDE4 inhibitor.
Journal: The Journal of pharmacology and experimental therapeutics 20010401
Title: Role of p38 MAP kinase in LPS-induced airway inflammation in the rat.
Journal: British journal of pharmacology 20010401
Title: Identification of substrate specificity determinants in human cAMP-specific phosphodiesterase 4A by single-point mutagenesis.
Journal: Cellular signalling 20010301
Title: Phthalazine PDE4 inhibitors. Part 2: the synthesis and biological evaluation of 6-methoxy-1,4-disubstituted derivatives.
Journal: Bioorganic & medicinal chemistry letters 20010108
Title: [Inhibition of uterine contractions: new in vitro pharmacological approaches on the pregnant human myometrium].
Journal: Therapie 20010101
Title: Effects of several glucocorticosteroids and PDE4 inhibitors on increases in total lung eosinophil peroxidase (EPO) levels following either systemic or intratracheal administration in sephadex- or ovalbumin-induced inflammatory models.
Journal: Inflammation 20000801
Title: Pharmacological modulation of secondary mediator systems--cyclic AMP and cyclic GMP--on inflammatory hyperalgesia.
Journal: British journal of pharmacology 19990601
Title: The effect of selective phosphodiesterase inhibitors in comparison with other anti-asthma drugs on allergen-induced eosinophilia in guinea-pig airways.
Journal: Pulmonary pharmacology 19950201
