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144092-31-9,MFCD00926134
Catalog No.:AA00ATCD

144092-31-9 | Ro 41-5253

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5mg
98%
1 week  
$368.00   $258.00
- +
10mg
98%
1 week  
$622.00   $435.00
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25mg
98%
1 week  
$1,368.00   $958.00
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50mg
98%
1 week  
$2,431.00   $1,702.00
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100mg
98%
1 week  
$4,336.00   $3,035.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00ATCD
Chemical Name:
Ro 41-5253
CAS Number:
144092-31-9
Molecular Formula:
C28H36O5S
Molecular Weight:
484.6474
MDL Number:
MFCD00926134
SMILES:
CCCCCCCOc1cc2c(cc1C(=Cc1ccc(cc1)C(=O)O)C)C(C)(C)CCS2(=O)=O
Properties
Computed Properties
 
Complexity:
801  
Covalently-Bonded Unit Count:
1  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
34  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
10  
XLogP3:
7.7  

Literature

Title: Dysregulation of retinoic acid receptor diminishes hepatocyte permissiveness to hepatitis B virus infection through modulation of sodium taurocholate cotransporting polypeptide (NTCP) expression.

Journal: The Journal of biological chemistry 20150227

Title: Retinoids and rexinoids inhibit hepatitis C virus independently of retinoid receptor signaling.

Journal: Microbes and infection 20140201

Title: Vitamin A deficiency aggravates iron deficiency by upregulating the expression of iron regulatory protein-2.

Journal: Nutrition (Burbank, Los Angeles County, Calif.) 20120301

Title: Glyphosate-based herbicides produce teratogenic effects on vertebrates by impairing retinoic acid signaling.

Journal: Chemical research in toxicology 20101018

Title: All trans retinoic acid nanodisks enhance retinoic acid receptor mediated apoptosis and cell cycle arrest in mantle cell lymphoma.

Journal: British journal of haematology 20100701

Title: Retinoic acid receptor antagonists inhibit miR-10a expression and block metastatic behavior of pancreatic cancer.

Journal: Gastroenterology 20091201

Title: Retinoic acid inhibits in vivo interleukin-2 gene expression and T-cell activation in mice.

Journal: Immunology 20090401

Title: Pharmacological manipulation of the RAR/RXR signaling pathway maintains the repopulating capacity of hematopoietic stem cells in culture.

Journal: Molecular endocrinology (Baltimore, Md.) 20090201

Title: The Retinoic Acid Receptor-alpha mediates human T-cell activation and Th2 cytokine and chemokine production.

Journal: BMC immunology 20080101

Title: Vitamin A potentiates CpG-mediated memory B-cell proliferation and differentiation: involvement of early activation of p38MAPK.

Journal: Blood 20070501

Title: A widely used retinoic acid receptor antagonist induces peroxisome proliferator-activated receptor-gamma activity.

Journal: Molecular pharmacology 20070501

Title: Retinoic acid regulates CD1d gene expression at the transcriptional level in human and rodent monocytic cells.

Journal: Experimental biology and medicine (Maywood, N.J.) 20070401

Title: Tributyltin and triphenyltin inhibit osteoclast differentiation through a retinoic acid receptor-dependent signaling pathway.

Journal: Biochemical and biophysical research communications 20070330

Title: The expression of retinoic acid receptors in lymph nodes of young children and the effect of all-trans-retinoic acid on the B cells from lymph nodes.

Journal: Journal of clinical immunology 20070101

Title: Effect of all-trans-retinoic acid on the differentiation, maturation and functions of dendritic cells derived from cord blood monocytes.

Journal: FEMS immunology and medical microbiology 20060801

Title: Retinoic acid exerts dual regulatory actions on the expression and nuclear localization of interferon regulatory factor-1.

Journal: Experimental biology and medicine (Maywood, N.J.) 20060501

Title: Physiological and receptor-selective retinoids modulate interferon gamma signaling by increasing the expression, nuclear localization, and functional activity of interferon regulatory factor-1.

Journal: The Journal of biological chemistry 20051028

Title: beta-Carotene conversion into vitamin A in human retinal pigment epithelial cells.

Journal: Investigative ophthalmology & visual science 20051001

Title: Synergistic induction of the MUC4 mucin gene by interferon-gamma and retinoic acid in human pancreatic tumour cells involves a reprogramming of signalling pathways.

Journal: Oncogene 20050908

Title: Expression of estrogen receptor alpha, retinoic acid receptor alpha and cellular retinoic acid binding protein II genes is coordinately regulated in human breast cancer cells.

Journal: Oncogene 20050623

Title: Retinoids and human breast cancer: in vivo effects of an antagonist for RAR-alpha.

Journal: Cancer letters 20050227

Title: Upregulation of connexin 43 by retinoids but not by non-provitamin A carotenoids requires RARs.

Journal: Nutrition and cancer 20050101

Title: Retinoic acid induces neuroblastoma cell death by inhibiting proteasomal degradation of retinoic acid receptor alpha.

Journal: Cancer research 20041101

Title: Histone deacetylase inhibitors enhance retinoid response in human breast cancer cell lines.

Journal: Anticancer research 20040101

Title: In vitro antimalarial activity of retinoids and the influence of selective retinoic acid receptor antagonists.

Journal: Acta tropica 20030801

Title: Erythropoietin and retinoic acid, secreted from the epicardium, are required for cardiac myocyte proliferation.

Journal: Developmental biology 20030315

Title: Retinoic acid stimulates the cell cycle machinery in normal T cells: involvement of retinoic acid receptor-mediated IL-2 secretion.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20021115

Title: Overexpression of mucin genes induced by interleukin-1 beta, tumor necrosis factor-alpha, lipopolysaccharide, and neutrophil elastase is inhibited by a retinoic acid receptor alpha antagonist.

Journal: Experimental lung research 20020601

Title: Regulation by retinoic acid of acylation-stimulating protein and complement C3 in human adipocytes.

Journal: The Biochemical journal 20010601

Title: Induction of the cytochrome P450 gene CYP26 during mucous cell differentiation of normal human tracheobronchial epithelial cells.

Journal: Molecular pharmacology 20000901

Title: Retinoic acid is a negative regulator for the differentiation of cord blood-derived human mast cell progenitors.

Journal: Blood 20000501

Title: Retinoid-mediated inhibition of cell growth with stimulation of apoptosis in aggressive B-cell lymphomas.

Journal: Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 19971001

Title: Regulation of retinoid-induced differentiation in embryonal carcinoma PCC4.aza1R cells: effects of retinoid-receptor selective ligands.

Journal: Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 19960301

Title: Involvement of retinoic acid receptor alpha in the stimulation of tissue-type plasminogen-activator gene expression in human endothelial cells.

Journal: European journal of biochemistry 19950901

Title: The prevention of adipose differentiation of 3T3-L1 cells caused by retinoic acid is elicited through retinoic acid receptor alpha.

Journal: Life sciences 19940101

Title: Different agonist- and antagonist-induced conformational changes in retinoic acid receptors analyzed by protease mapping.

Journal: Molecular and cellular biology 19940101

Title: A retinoic acid receptor alpha antagonist selectively counteracts retinoic acid effects.

Journal: Proceedings of the National Academy of Sciences of the United States of America 19920801

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