Catalog No.:AA01JNGC

1445847-37-9 | 9-(2-Cyclopropylethynyl)-2-[(2S)-1,4-dioxan-2-ylmethoxy]-6,7-dihydro-4H-pyrimido[6,1-a]isoquinolin-4-one

Name: Name:9-(2-Cyclopropylethynyl)-2-[(2S)-1,4-dioxan-2-ylmethoxy]-6,7-dihydro-4H-pyrimido[6,1-a]isoquinolin-4-one
Brand: AABLOCKS
SKU: AA01JNGC
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5mg

99%

1 week

$471.00 $330.00

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10mg

99%

1 week

$765.00 $535.00

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50mg

99%

1 week

$2,431.00 $1,702.00

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100mg

99%

1 week

$4,495.00 $3,147.00

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Technical Information
Properties
Literature
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Technical Information
Properties
Literature

Technical Information

Catalog Number:

AA01JNGC

Chemical Name:

9-(2-Cyclopropylethynyl)-2-[(2S)-1,4-dioxan-2-ylmethoxy]-6,7-dihydro-4H-pyrimido[6,1-a]isoquinolin-4-one

CAS Number:

1445847-37-9

Molecular Formula:

C22H22N2O4

Molecular Weight:

378.4211

SMILES:

O=c1nc(OC[C@@H]2COCCO2)cc2n1CCc1c2ccc(c1)C#CC1CC1

Properties

Literature

Title: Sundqvist M, et al. Similarities and differences between the responses induced in human phagocytes through activation of the medium chain fatty acid receptor GPR84 and the short chain fatty acid receptor FFA2R. Biochim Biophys Acta Mol Cell Res. 2018 May;1865(5):695-708.

Title: F. Vanhoutte, et al. Human safety, pharmacokinetics and pharmacodynamics of the GPR84 antagonist GLPG1205, a potential new approach to treat IBD.

Title: L.Saniere, et al. Characterization of GLPG1205 in Mouse Fibrosis Models: A Potent and Selective Antagonist of GPR84 for Treatment of Idiopathic Pulmonary Fibrosis. American Journal of Respiratory and Critical Care Medicine 2019;199:A1046

Title: F. Vanhoutte, et al. Human safety, pharmacokinetics and pharmacodynamics

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