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1448347-49-6,MFCD29036964
Catalog No.:AA00ABLB

1448347-49-6 | AG-120

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
98%
in stock  
$13.00   $9.00
- +
100mg
98%
in stock  
$73.00   $51.00
- +
250mg
98%
in stock  
$123.00   $86.00
- +
1g
98%
in stock  
$331.00   $232.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00ABLB
Chemical Name:
AG-120
CAS Number:
1448347-49-6
Molecular Formula:
C28H22ClF3N6O3
Molecular Weight:
582.9609
MDL Number:
MFCD29036964
SMILES:
N#Cc1ccnc(c1)N1C(=O)CC[C@H]1C(=O)N([C@@H](c1ccccc1Cl)C(=O)NC1CC(C1)(F)F)c1cncc(c1)F
Properties
Computed Properties
 
Complexity:
1050  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Heavy Atom Count:
41  
Hydrogen Bond Acceptor Count:
9  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
7  
XLogP3:
3.4  

Literature

Title: Durable Remissions with Ivosidenib in IDH1-Mutated Relapsed or Refractory AML.

Journal: The New England journal of medicine 20180621

Title: Evidence for Clinical Differentiation and Differentiation Syndrome in Patients With Acute Myeloid Leukemia and IDH1 Mutations Treated With the Targeted Mutant IDH1 Inhibitor, AG-120.

Journal: Clinical lymphoma, myeloma & leukemia 20160801

Title: Cancer-associated IDH1 mutations produce 2-hydroxyglutarate.

Journal: Nature 20091210

Title: Popovici-Muller J, et al. Discovery of AG-120 (Ivosidenib): A First-in-Class Mutant IDH1 Inhibitor for the Treatment of IDH1Mutant Cancers. ACS Med Chem Lett. 2018 Jan 19;9(4):300-305.

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