+1 858-523-8231
Login | Register
AA Blocks, Building Blocks, Catalysts, Inhibitors
Login | Register
Home Fluorides 1448671-31-5
1448671-31-5,MFCD28963899
Catalog No.:AA001K69

1448671-31-5 | Thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione, 5-[[(4S)-4-hydroxy-4-methyl-2-isoxazolidinyl]carbonyl]-3-methyl-1-(1-methylethyl)-6-[[5-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl]-

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$37.00   $26.00
- +
2mg
98%
in stock  
$57.00   $40.00
- +
5mg
98%
in stock  
$85.00   $60.00
- +
10mg
98%
in stock  
$134.00   $94.00
- +
1g
98%
in stock  
$4,712.00   $3,298.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA001K69
Chemical Name:
Thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione, 5-[[(4S)-4-hydroxy-4-methyl-2-isoxazolidinyl]carbonyl]-3-methyl-1-(1-methylethyl)-6-[[5-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl]-
CAS Number:
1448671-31-5
Molecular Formula:
C21H24F3N5O5S
Molecular Weight:
515.5060
MDL Number:
MFCD28963899
SMILES:
O=C(c1c(Cc2c(C)[nH]nc2C(F)(F)F)sc2c1c(=O)n(c(=O)n2C(C)C)C)N1OC[C@@](C1)(C)O
Properties
Computed Properties
 
Complexity:
894  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
35  
Hydrogen Bond Acceptor Count:
10  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
4  
XLogP3:
2  

Downstream Synthesis Route

[1]CurrentPatentAssignee:ASTRAZENECAPLC-WO2004/65394,2004,A1Locationinpatent:Page64-65

[1]CurrentPatentAssignee:ASTRAZENECAPLC-WO2004/65394,2004,A1Locationinpatent:Page38

Literature

Title: Detection of Chemical Engagement of Solute Carrier Proteins by a Cellular Thermal Shift Assay.

Journal: ACS chemical biology 20180615

Title: Bola BM, et al. Inhibition of monocarboxylate transporter-1 (MCT1) by AZD3965 enhances radiosensitivity by reducing lactate transport. Mol Cancer Ther. 2014 Dec;13(12):2805-16.

Title: Polanski R, et al. Activity of the monocarboxylate transporter 1 inhibitor AZD3965 in small cell lung cancer. Clin Cancer Res. 2014 Feb 15;20(4):926-37.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Related Products of 1448671-31-5
496791-37-8

496791-37-8
Building Blocks
More >
Tags:1448671-31-5 Molecular Formula|1448671-31-5 MDL|1448671-31-5 SMILES|1448671-31-5 Thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione, 5-[[(4S)-4-hydroxy-4-methyl-2-isoxazolidinyl]carbonyl]-3-methyl-1-(1-methylethyl)-6-[[5-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl]-