Catalog No.:AA001KGG

1450833-55-2 | Sulfamic acid, [(1R,2R,3S,4R)-2,3-dihydroxy-4-[[2-[3-[(trifluoromethyl)thio]phenyl]pyrazolo[1,5-a]pyrimidin-7-yl]amino]cyclopentyl]methyl ester

Name: Name:Sulfamic acid, [(1R,2R,3S,4R)-2,3-dihydroxy-4-[[2-[3-[(trifluoromethyl)thio]phenyl]pyrazolo[1,5-a]pyrimidin-7-yl]amino]cyclopentyl]methyl ester
Brand: AABLOCKS
SKU: AA001KGG
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1mg

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$44.00 $31.00

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10mg

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50mg

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$456.00 $320.00

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Technical Information
Properties
Downstream Synthesis Route
Literature
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Technical Information
Properties
Downstream Synthesis Route
Literature

Technical Information

Catalog Number:

AA001KGG

Chemical Name:

Sulfamic acid, [(1R,2R,3S,4R)-2,3-dihydroxy-4-[[2-[3-[(trifluoromethyl)thio]phenyl]pyrazolo[1,5-a]pyrimidin-7-yl]amino]cyclopentyl]methyl ester

CAS Number:

1450833-55-2

Molecular Formula:

C19H20F3N5O5S2

Molecular Weight:

519.5178

MDL Number:

MFCD28964160

SMILES:

O[C@H]1[C@@H](C[C@@H]([C@H]1O)COS(=O)(=O)N)Nc1ccnc2n1nc(c2)c1cccc(c1)SC(F)(F)F

Properties

Downstream Synthesis Route

1450833-55-2

1450834-90-8

1450834-91-9

[1]CurrentPatentAssignee:TAKEDAPHARMACEUTICALCOMPANYLIMITED-US2013/217682,2013,A1Locationinpatent:Paragraph0425;0426

tert-butyl({(3aR,4R,6aS)-2,2-dimethyl-6-(2-{3-(trifluoromethylthio)phenyl}pyrazolo1,5-apyrimidin-7-yl)aminotetrahydro-3aH-cyclopentad1,3dioxol-4-yl}methoxy)sulfonylcarbamate

1450833-55-2

[1]CurrentPatentAssignee:TAKEDAPHARMACEUTICALCOMPANYLIMITED-US2013/217682,2013,A1Locationinpatent:Paragraph0429

(3aR,4R,6R,6aS)-6-amino-2,2-dumethyltetrahydro-3aH-cyclopentad1,3dioxol-4-ylmethanolhydrochloride

1450833-55-2

[1]CurrentPatentAssignee:TAKEDAPHARMACEUTICALCOMPANYLIMITED-WO2016/69393,2016,A1

((3aR,4R,6R,6aS)-2,2-dimethyl-6-((2-(3-((trifluoromethyl)thio)phenyl)pyrazolo1,5-apyrimidin-7-yl)amino)tetrahydro-3aH-cyclopentad1,3dioxol-4-yl)methyltert-butoxycarbonylsulfamate

1450833-55-2

[1]CurrentPatentAssignee:TAKEDAPHARMACEUTICALCOMPANYLIMITED-WO2016/69393,2016,A1Locationinpatent:Paragraph0164-0165

Literature

Title: Hyer ML, et al. A small-molecule inhibitor of the ubiquitin activating enzyme for cancer treatment. Nat Med. 2018 Feb;24(2):186-193.

Title: Best SR, et al. TAK-243, a small molecule inhibitor of ubiquitin-activating enzyme (UAE), induces ER stress and apoptosis in diffuse large B-cell lymphoma (DLBCL) cells. Blood 2017 130:1533.

Title: Samir H. Barghout, et al. TAK-243 Is a Selective UBA1 Inhibitor That Displays Preclinical Activity in Acute Myeloid Leukemia (AML). Blood 2017, 130:814.

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SDS