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145084-28-2,MFCD00917023
Catalog No.:AA001KGL

145084-28-2 | Urea, N-[(3R)-2,3-dihydro-1-[2-(2-methylphenyl)-2-oxoethyl]-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]-N'-(3-methylphenyl)-

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  • Technical Information
  • Properties
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Technical Information
Catalog Number:
AA001KGL
Chemical Name:
Urea, N-[(3R)-2,3-dihydro-1-[2-(2-methylphenyl)-2-oxoethyl]-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]-N'-(3-methylphenyl)-
CAS Number:
145084-28-2
Molecular Formula:
C32H28N4O3
Molecular Weight:
516.5897
MDL Number:
MFCD00917023
SMILES:
Cc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccc2)c2c(N(C1=O)CC(=O)c1ccccc1C)cccc2
Properties
Computed Properties
 
Complexity:
913  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
39  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
6  
XLogP3:
5.6  

Literature

Title: Cell-type-specific CCK2 receptor signaling underlies the cholecystokinin-mediated selective excitation of hippocampal parvalbumin-positive fast-spiking basket cells.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20110727

Title: Stimulatory effect of N-methyltyramine, a congener of beer, on pancreatic secretion in conscious rats.

Journal: Alcoholism, clinical and experimental research 20100201

Title: Signaling through cholesterol esterification: a new pathway for the cholecystokinin 2 receptor involved in cell growth and invasion.

Journal: Journal of lipid research 20091101

Title: Combination of sulindac and antimicrobial eradication of Helicobacter pylori prevents progression of gastric cancer in hypergastrinemic INS-GAS mice.

Journal: Cancer research 20091015

Title: The effect and mechanism of action of capsaicin on gastric acid output.

Journal: Journal of gastroenterology 20090101

Title: Hypergastrinemia increases gastric epithelial susceptibility to apoptosis.

Journal: Regulatory peptides 20080207

Title: Cell type-specific gating of perisomatic inhibition by cholecystokinin.

Journal: Nature neuroscience 20070901

Title: Necessity of intracellular cyclic AMP in inducing gastric acid secretion via muscarinic M3 and cholecystokinin2 receptors on parietal cells in isolated mouse stomach.

Journal: Life sciences 20050902

Title: Secretory organelles in ECL cells: effects of pharmacological blockade of the gastrin/CCK2 receptor versus its elimination by gene targeting.

Journal: Inflammopharmacology 20050101

Title: Gastrin-induced cyclooxygenase-2 expression in Barrett's carcinogenesis.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20040715

Title: Impaired gastric secretion and lack of trophic responses to hypergastrinemia in M3 muscarinic receptor knockout mice.

Journal: Gastroenterology 20031201

Title: Pharmacological analysis of CCK(2) receptor ligands using COS-7 and SK-N-MC cells, expressing the human CCK(2) receptor.

Journal: Regulatory peptides 20020115

Title: Effects of CCK2 receptor blockade on growth parameters in gastrointestinal tract and pancreas in rats.

Journal: Pharmacology & toxicology 20011001

Title: Proinflammatory role of leptin in experimental colitis in rats benefit of cholecystokinin-B antagonist and beta3-agonist.

Journal: Life sciences 20010622

Title: Characterization of the binding of a novel radioligand to CCKB/gastrin receptors in membranes from rat cerebral cortex.

Journal: British journal of pharmacology 19990301

Title: (3R)-N-(1-(tert-butylcarbonylmethyl)-2,3-dihydro-2-oxo-5-(2-pyridyl)-1H-1,4-benzodiazepin-3-yl)-N'-(3-(methylamino)phenyl)urea (YF476): a potent and orally active gastrin/CCK-B antagonist.

Journal: Journal of medicinal chemistry 19970131

Title: Pharmacological profile of (R)-1-[2,3-dihydro-1-(2'-methylphenacyl)-2-oxo- 5-phenyl-1H-1,4-benzodiazepin-3-yl]-3-(3-methylphenyl)urea (YM022), a new potent and selective gastrin/cholecystokinin-B receptor antagonist, in vitro and in vivo.

Journal: The Journal of pharmacology and experimental therapeutics 19940501

Title: Nishida A, et al. Pharmacological profile of (R)-1-,3-dihydro-1-(2'-methylphenacyl)-2-oxo- 5-phenyl-1H-1,4-benzodiazepin-3-yl-3-(3-methylphenyl)urea (YM022), a new potent and selective gastrin/cholecystokinin-B receptor antagonist, in vitro and in vivo.J Pharmacol Exp Ther. 1994 May;269(2):725-31.

Title: Kitano M, et al. Long-lasting cholecystokinin(2) receptor blockade after a single subcutaneous injection of YF476 or YM022.Br J Pharmacol. 2000 Jun;130(3):699-705.

Title: Beinborn M, et al. Small synthetic ligands of the cholecystokinin-B/gastrin receptor can mimic the function of endogenous peptide hormones.Yale J Biol Med. 1998 May-Aug;71(3-4):337-46.

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Tags:145084-28-2 Molecular Formula|145084-28-2 MDL|145084-28-2 SMILES|145084-28-2 Urea, N-[(3R)-2,3-dihydro-1-[2-(2-methylphenyl)-2-oxoethyl]-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]-N'-(3-methylphenyl)-