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145733-36-4,MFCD00865905
Catalog No.:AA001DAK

145733-36-4 | Tasosartan

Pack Size
Purity
Availability
Price(USD)
Quantity
  
25mg
≥98%
in stock  
$133.00   $93.00
- +
50mg
≥98%
in stock  
$238.00   $166.00
- +
100mg
≥98%
in stock  
$418.00   $292.00
- +
250mg
≥98%
in stock  
$978.00   $684.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA001DAK
Chemical Name:
Tasosartan
CAS Number:
145733-36-4
Molecular Formula:
C23H21N7O
Molecular Weight:
411.4591
MDL Number:
MFCD00865905
SMILES:
Cc1nc(C)c2c(n1)N(Cc1ccc(cc1)c1ccccc1c1nn[nH]n1)C(=O)CC2
Properties
Properties
 
BP:
759.4±70.0°C at 760 mmHg  
Form:
Solid  
MP:
197-199°  
Storage:
Keep in dry area;2-8℃;  

Computed Properties
 
Complexity:
625  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
31  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
4  
XLogP3:
3  

Literature

Title: Evaluating the Role of Multidrug Resistance Protein 3 (MDR3) Inhibition in Predicting Drug-Induced Liver Injury Using 125 Pharmaceuticals.

Journal: Chemical research in toxicology 20170515

Title: Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

Journal: PLoS computational biology 20111201

Title: Angiotensin II receptor type 1 (AT1) selective nonpeptidic antagonists--a perspective.

Journal: Bioorganic & medicinal chemistry 20101215

Title: A predictive ligand-based Bayesian model for human drug-induced liver injury.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20101201

Title: Pharmacophore, drug metabolism, and pharmacokinetics models on non-peptide AT1, AT2, and AT1/AT2 angiotensin II receptor antagonists.

Journal: Journal of medicinal chemistry 20050630

Title: Angiotensin II AT1 receptor antagonists. Clinical implications of active metabolites.

Journal: Journal of medicinal chemistry 20030605

Title: Novel human metabolites of the angiotensin-II antagonist tasosartan and their pharmacological effects.

Journal: Bioorganic & medicinal chemistry letters 20020805

Title: Pharmacology of AT1-receptor blockers.

Journal: Blood pressure. Supplement 20010101

Title: Tasosartan, enoltasosartan, and angiotensin II receptor blockade: the confounding role of protein binding.

Journal: The Journal of pharmacology and experimental therapeutics 20001101

Title: Nonpeptide angiotensin II receptor antagonists: the next generation in antihypertensive therapy.

Journal: Journal of medicinal chemistry 19960202

Title: Maillard MP, et al. Tasosartan, enoltasosartan, and angiotensin II receptor blockade: the confounding role of protein binding. J Pharmacol Exp Ther. 2000 Nov;295(2):649-54.

Title: Elokdah HM, et al. Novel human metabolites of the angiotensin-II antagonist Tasosartan and their pharmacological effects. Bioorg Med Chem Lett. 2002 Aug 5;12(15):1967-71.

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