145915-60-2,MFCD00938569
Catalog No.:AA001DFP

145915-60-2 | 1H-Isoindole-1,3(2H)-dione, 5,6-bis[(4-fluorophenyl)amino]-

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
98%
in stock  
$340.00   $238.00
- +
10mg
98%
in stock  
$499.00   $349.00
- +
25mg
98%
in stock  
$1,029.00   $720.00
- +
50mg
98%
in stock  
$1,736.00   $1,215.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA001DFP
Chemical Name:
1H-Isoindole-1,3(2H)-dione, 5,6-bis[(4-fluorophenyl)amino]-
CAS Number:
145915-60-2
Molecular Formula:
C20H13F2N3O2
Molecular Weight:
365.3329
MDL Number:
MFCD00938569
SMILES:
Fc1ccc(cc1)Nc1cc2C(=O)NC(=O)c2cc1Nc1ccc(cc1)F
Properties
Computed Properties
 
Complexity:
511  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
27  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
3  
Isotope Atom Count:
0  
Rotatable Bond Count:
4  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
4  

Literature

Title: A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.

Journal: The Biochemical journal 20130415

Title: Inhibition of protein kinase C β(2) prevents tumor necrosis factor-α-induced apoptosis and oxidative stress in endothelial cells: the role of NADPH oxidase subunits.

Journal: Journal of vascular research 20120101

Title: Inhibition of protein kinase Cβ reverses increased blood-brain barrier permeability during hyperglycemic stroke and prevents edema formation in vivo.

Journal: Stroke 20111101

Title: Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity.

Journal: Nature biotechnology 20111101

Title: Priming of eosinophils by GM-CSF is mediated by protein kinase CbetaII-phosphorylated L-plastin.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20110601

Title: Potent inhibitors of amyloid β fibrillization, 4,5-dianilinophthalimide and staurosporine aglycone, enhance degradation of preformed aggregates of mutant Notch3.

Journal: Biochemical and biophysical research communications 20101105

Title: Thioflavin T fluorescence assay for beta-lactoglobulin fibrils hindered by DAPH.

Journal: Journal of structural biology 20090301

Title: Role of protein kinase C beta2 activation in TNF-alpha-induced human vascular endothelial cell apoptosis.

Journal: Canadian journal of physiology and pharmacology 20090301

Title: High glucose-induced Nox1-derived superoxides downregulate PKC-betaII, which subsequently decreases ACE2 expression and ANG(1-7) formation in rat VSMCs.

Journal: American journal of physiology. Heart and circulatory physiology 20090101

Title: Inhibition of protein kinase C beta II downregulates tristetraprolin expression in activated macrophages.

Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20080501

Title: Small-molecule aggregates inhibit amyloid polymerization.

Journal: Nature chemical biology 20080301

Title: Aggregator compounds confound amyloid fibrillization assay.

Journal: Nature chemical biology 20080301

Title: MetaSite: understanding metabolism in human cytochromes from the perspective of the chemist.

Journal: Journal of medicinal chemistry 20051103

Title: Synthesis of 4,5-dianilinophthalimide and related analogues for potential treatment of Alzheimer's disease via palladium-catalyzed amination.

Journal: The Journal of organic chemistry 20050902

Title: Inhibition of erbB receptor family members protects HaCaT keratinocytes from ultraviolet-B-induced apoptosis.

Journal: The Journal of investigative dermatology 20030301

Title: Signaling-inactive epidermal growth factor receptor/ligand complexes in intact carcinoma cells by quinazoline tyrosine kinase inhibitors.

Journal: Cancer research 20010801

Title: A carboxy-terminal deletion mutant of protein kinase C beta II inhibits insulin-stimulated 2-deoxyglucose uptake in L6 rat skeletal muscle cells.

Journal: Molecular endocrinology (Baltimore, Md.) 19961001

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Tags:145915-60-2 Molecular Formula|145915-60-2 MDL|145915-60-2 SMILES|145915-60-2 1H-Isoindole-1,3(2H)-dione, 5,6-bis[(4-fluorophenyl)amino]-
Catalog No.: AA001DFP
145915-60-2,MFCD00938569
145915-60-2 | 1H-Isoindole-1,3(2H)-dione, 5,6-bis[(4-fluorophenyl)amino]-
Pack Size: 5mg
Purity: 98%
in stock
$340.00 $238.00
Pack Size: 10mg
Purity: 98%
in stock
$499.00 $349.00
Pack Size: 25mg
Purity: 98%
in stock
$1,029.00 $720.00
Pack Size: 50mg
Purity: 98%
in stock
$1,736.00 $1,215.00
Quantity
- +
Add to Card
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bulk Quotation Request
Technical Information
Catalog Number: AA001DFP
Chemical Name: 1H-Isoindole-1,3(2H)-dione, 5,6-bis[(4-fluorophenyl)amino]-
CAS Number: 145915-60-2
Molecular Formula: C20H13F2N3O2
Molecular Weight: 365.3329
MDL Number: MFCD00938569
SMILES: Fc1ccc(cc1)Nc1cc2C(=O)NC(=O)c2cc1Nc1ccc(cc1)F
Properties
Complexity: 511  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 27  
Hydrogen Bond Acceptor Count: 6  
Hydrogen Bond Donor Count: 3  
Isotope Atom Count: 0  
Rotatable Bond Count: 4  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 4  
Literature fold

Title: A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.

Journal: The Biochemical journal20130415

Title: Inhibition of protein kinase C β(2) prevents tumor necrosis factor-α-induced apoptosis and oxidative stress in endothelial cells: the role of NADPH oxidase subunits.

Journal: Journal of vascular research20120101

Title: Inhibition of protein kinase Cβ reverses increased blood-brain barrier permeability during hyperglycemic stroke and prevents edema formation in vivo.

Journal: Stroke20111101

Title: Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity.

Journal: Nature biotechnology20111101

Title: Priming of eosinophils by GM-CSF is mediated by protein kinase CbetaII-phosphorylated L-plastin.

Journal: Journal of immunology (Baltimore, Md. : 1950)20110601

Title: Potent inhibitors of amyloid β fibrillization, 4,5-dianilinophthalimide and staurosporine aglycone, enhance degradation of preformed aggregates of mutant Notch3.

Journal: Biochemical and biophysical research communications20101105

Title: Thioflavin T fluorescence assay for beta-lactoglobulin fibrils hindered by DAPH.

Journal: Journal of structural biology20090301

Title: Role of protein kinase C beta2 activation in TNF-alpha-induced human vascular endothelial cell apoptosis.

Journal: Canadian journal of physiology and pharmacology20090301

Title: High glucose-induced Nox1-derived superoxides downregulate PKC-betaII, which subsequently decreases ACE2 expression and ANG(1-7) formation in rat VSMCs.

Journal: American journal of physiology. Heart and circulatory physiology20090101

Title: Inhibition of protein kinase C beta II downregulates tristetraprolin expression in activated macrophages.

Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.]20080501

Title: Small-molecule aggregates inhibit amyloid polymerization.

Journal: Nature chemical biology20080301

Title: Aggregator compounds confound amyloid fibrillization assay.

Journal: Nature chemical biology20080301

Title: MetaSite: understanding metabolism in human cytochromes from the perspective of the chemist.

Journal: Journal of medicinal chemistry20051103

Title: Synthesis of 4,5-dianilinophthalimide and related analogues for potential treatment of Alzheimer's disease via palladium-catalyzed amination.

Journal: The Journal of organic chemistry20050902

Title: Inhibition of erbB receptor family members protects HaCaT keratinocytes from ultraviolet-B-induced apoptosis.

Journal: The Journal of investigative dermatology20030301

Title: Signaling-inactive epidermal growth factor receptor/ligand complexes in intact carcinoma cells by quinazoline tyrosine kinase inhibitors.

Journal: Cancer research20010801

Title: A carboxy-terminal deletion mutant of protein kinase C beta II inhibits insulin-stimulated 2-deoxyglucose uptake in L6 rat skeletal muscle cells.

Journal: Molecular endocrinology (Baltimore, Md.)19961001

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