Home Amines 145915-58-8
145915-58-8,MFCD00236442
Catalog No.:AA001DFQ

145915-58-8 | 1H-Isoindole-1,3(2H)-dione, 5,6-bis(phenylamino)-

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1mg
≥98%
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$70.00   $49.00
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5mg
≥98%
in stock  
$223.00   $156.00
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10mg
≥98%
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$409.00   $286.00
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25mg
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA001DFQ
Chemical Name:
1H-Isoindole-1,3(2H)-dione, 5,6-bis(phenylamino)-
CAS Number:
145915-58-8
Molecular Formula:
C20H15N3O2
Molecular Weight:
329.3520
MDL Number:
MFCD00236442
SMILES:
O=C1NC(=O)c2c1cc(Nc1ccccc1)c(c2)Nc1ccccc1
Properties
Computed Properties
 
Complexity:
453  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
25  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
4  
XLogP3:
3.8  

Downstream Synthesis Route

[1]Hennessy,EdwardJ.;Buchwald,StephenL.[JournalofOrganicChemistry,2005,vol.70,#18,p.7371-7375]

Literature

Title: Inhibition of protein kinase C β(2) prevents tumor necrosis factor-α-induced apoptosis and oxidative stress in endothelial cells: the role of NADPH oxidase subunits.

Journal: Journal of vascular research 20120101

Title: Inhibition of protein kinase Cβ reverses increased blood-brain barrier permeability during hyperglycemic stroke and prevents edema formation in vivo.

Journal: Stroke 20111101

Title: Potent inhibitors of amyloid β fibrillization, 4,5-dianilinophthalimide and staurosporine aglycone, enhance degradation of preformed aggregates of mutant Notch3.

Journal: Biochemical and biophysical research communications 20101105

Title: Novel anilinophthalimide derivatives as potential probes for beta-amyloid plaque in the brain.

Journal: Bioorganic & medicinal chemistry 20100201

Title: Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Journal: Nature chemical biology 20091001

Title: Thioflavin T fluorescence assay for beta-lactoglobulin fibrils hindered by DAPH.

Journal: Journal of structural biology 20090301

Title: Role of protein kinase C beta2 activation in TNF-alpha-induced human vascular endothelial cell apoptosis.

Journal: Canadian journal of physiology and pharmacology 20090301

Title: High glucose-induced Nox1-derived superoxides downregulate PKC-betaII, which subsequently decreases ACE2 expression and ANG(1-7) formation in rat VSMCs.

Journal: American journal of physiology. Heart and circulatory physiology 20090101

Title: Inhibition of protein kinase C beta II downregulates tristetraprolin expression in activated macrophages.

Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20080501

Title: Small-molecule aggregates inhibit amyloid polymerization.

Journal: Nature chemical biology 20080301

Title: MetaSite: understanding metabolism in human cytochromes from the perspective of the chemist.

Journal: Journal of medicinal chemistry 20051103

Title: Synthesis of 4,5-dianilinophthalimide and related analogues for potential treatment of Alzheimer's disease via palladium-catalyzed amination.

Journal: The Journal of organic chemistry 20050902

Title: Inhibition of erbB receptor family members protects HaCaT keratinocytes from ultraviolet-B-induced apoptosis.

Journal: The Journal of investigative dermatology 20030301

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry 20020419

Title: Arterial epidermal growth factor receptor expression in deoxycorticosterone acetate-salt hypertension.

Journal: Hypertension (Dallas, Tex. : 1979) 20011201

Title: Signaling-inactive epidermal growth factor receptor/ligand complexes in intact carcinoma cells by quinazoline tyrosine kinase inhibitors.

Journal: Cancer research 20010801

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Tags:145915-58-8 Molecular Formula|145915-58-8 MDL|145915-58-8 SMILES|145915-58-8 1H-Isoindole-1,3(2H)-dione, 5,6-bis(phenylamino)-