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146-56-5,MFCD00055212
Catalog No.:AA003QJH

146-56-5 | FLUPHENAZINE HYDROCHLORIDE

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500mg
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>98.0%(HPLC)
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA003QJH
Chemical Name:
FLUPHENAZINE HYDROCHLORIDE
CAS Number:
146-56-5
Molecular Formula:
C22H28Cl2F3N3OS
Molecular Weight:
510.4434
MDL Number:
MFCD00055212
SMILES:
OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F.Cl.Cl
Properties
Properties
 
BP:
568.3°C at 760 mmHg  
Form:
Solid  
MP:
200-2020C  
Solubility:
Soluble in DMSO and methanol.  
Stability:
Hygroscopic  
Storage:
Inert atmosphere;Room Temperature;  

Computed Properties
 
Complexity:
544  
Covalently-Bonded Unit Count:
3  
Heavy Atom Count:
32  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
6  

Literature

Title: Intrathecal chlorprothixene, cis(z)-flupenthixol, chlorpromazine and fluphenazine for prolonged spinal blockades of sensory and motor functions in rats.

Journal: European journal of pharmacology 20121015

Title: Effectiveness of switching from long-acting injectable fluphenazine or haloperidol decanoate to long-acting injectable risperidone microspheres: an open-label, randomized controlled trial.

Journal: The Journal of clinical psychiatry 20120501

Title: Resveratrol reduces vacuous chewing movements induced by acute treatment with fluphenazine.

Journal: Pharmacology, biochemistry, and behavior 20120401

Title: Cocaine modulates pathways for photic and nonphotic entrainment of the mammalian SCN circadian clock.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20120315

Title: Opposite actions of dopamine on aversive and appetitive memories in the crab.

Journal: Learning & memory (Cold Spring Harbor, N.Y.) 20120120

Title: Attentional and emotional functioning in schizophrenia patients treated with conventional and atypical antipsychotic drugs.

Journal: Medical science monitor : international medical journal of experimental and clinical research 20120101

Title: First generation antipsychotics switch with Risperidone in the treatment of chronic schizophrenic patients.

Journal: Psychiatria Danubina 20111201

Title: Methylphenidate and fluphenazine, but not amphetamine, differentially affect impulsive choice in spontaneously hypertensive, Wistar-Kyoto and Sprague-Dawley rats.

Journal: Brain research 20110617

Title: Evaluation of five antischizophrenic agents against Toxoplasma gondii in human cell cultures.

Journal: The Journal of parasitology 20110201

Title: Potentiating effect of fluphenazine decanoate and risperidone on development of neuroleptic malignant syndrome.

Journal: General hospital psychiatry 20110101

Title: Styryl-based and tricyclic compounds as potential anti-prion agents.

Journal: PloS one 20110101

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Treatment of schizophrenia with depot preparations of fluphenazine, haloperidol, and risperidone among inpatients at state-operated psychiatric facilities.

Journal: Schizophrenia research 20100601

Title: Stimulation of neuronal KATP channels by cGMP-dependent protein kinase: involvement of ROS and 5-hydroxydecanoate-sensitive factors in signal transduction.

Journal: American journal of physiology. Cell physiology 20100401

Title: The role of CYP2D6 and TaqI A polymorphisms in malignant neuroleptic syndrome: two case reports with three episodes.

Journal: Psychiatria Danubina 20100301

Title: [A case of drug-induced syndrome of inappropriate secretion of antidiuretic hormone].

Journal: Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia 20100101

Title: Automated high-content live animal drug screening using C. elegans expressing the aggregation prone serpin α1-antitrypsin Z.

Journal: PloS one 20100101

Title: Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Journal: Nature chemical biology 20091001

Title: Second-derivative synchronous fluorescence spectroscopy for the simultaneous determination of fluphenazine hydrochloride and nortriptyline hydrochloride in pharmaceutical preparations.

Journal: Journal of fluorescence 20090901

Title: Pregnancy and atypical antipsychotics.

Journal: Psychiatria Danubina 20090901

Title: Simultaneous chemiluminescence determination of promazine and fluphenazine using support vector regression.

Journal: Talanta 20090715

Title: Chronic treatment with fluphenazine alters parameters of oxidative stress in liver and kidney of rats.

Journal: Basic & clinical pharmacology & toxicology 20090701

Title: Water taste transduction pathway is calcium dependent in Drosophila.

Journal: Chemical senses 20090601

Title: Use of aripiprazole in tardive dyskinesia: an open label study of six cases.

Journal: The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry 20090101

Title: Validation of derivative spectrophotometry method for determination of active ingredients from neuroleptics in pharmaceutical preparations.

Journal: Acta poloniae pharmaceutica 20090101

Title: Effects of mental illness and aging in two thalamic nuclei.

Journal: Schizophrenia research 20081201

Title: Attenuation of receptor-dependent and -independent vasoconstriction in the human radial artery.

Journal: European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20081001

Title: Antipsychotic drugs up-regulate tryptophan hydroxylase in ADF neurons of Caenorhabditis elegans: role of calcium-calmodulin-dependent protein kinase II and transient receptor potential vanilloid channel.

Journal: Journal of neuroscience research 20080815

Title: Neuroleptic malignant syndrome presenting with acute renal failure.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20080515

Title: A mutual prodrug ester of GABA and perphenazine exhibits antischizophrenic efficacy with diminished extrapyramidal effects.

Journal: Journal of medicinal chemistry 20080508

Title: Reward system activation in schizophrenic patients switched from typical neuroleptics to olanzapine.

Journal: Psychopharmacology 20080301

Title: Treatment compliance of outpatients with schizophrenia: patient's attitudes, demographic, clinical and therapeutic variables.

Journal: Psychiatria Danubina 20080301

Title: The antipsychotic drug, fluphenazine, effectively reverses mechanical allodynia in rat models of neuropathic pain.

Journal: Psychopharmacology 20080101

Title: Spectrofluorometric determination of olanzapine and fluphenazine hydrochloride in pharmaceutical preparations and human plasma using eosin: application to stability studies.

Journal: Journal of AOAC International 20080101

Title: Treatment of schizophrenia with long-acting fluphenazine, haloperidol, or risperidone.

Journal: Schizophrenia bulletin 20071101

Title: Glycopyrrolate for clozapine-induced sialorrhea.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20071001

Title: Diphenyl diselenide decreases the prevalence of vacuous chewing movements induced by fluphenazine in rats.

Journal: Psychopharmacology 20071001

Title: Photoaddition of fluphenazine to nucleophiles in peptides and proteins. Possible cause of immune side effects.

Journal: Chemical research in toxicology 20071001

Title: Differential effects of typical and atypical antipsychotics on brain myelination in schizophrenia.

Journal: Schizophrenia research 20070701

Title: Switching as only temporal solution for patients with antipsychotic-associated diabetes: further observations.

Journal: Psychiatria Danubina 20070601

Title: Fatal hyponatremia and other metabolic disturbances associated with psychotropic drug polypharmacy.

Journal: International journal of clinical pharmacology and therapeutics 20070501

Title: Characteristics and use patterns of patients taking first-generation depot antipsychotics or oral antipsychotics for schizophrenia.

Journal: Psychiatric services (Washington, D.C.) 20070401

Title: Intracerebroventricular ethanol-induced conditioned place preferences are prevented by fluphenazine infusions into the nucleus accumbens of rats.

Journal: Behavioral neuroscience 20070401

Title: The effects of olanzapine and fluphenazine on plasma cortisol, prolactin and muscle rigidity in schizophrenic patients: a double blind study.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20070330

Title: Involvement of Ca2+- and cyclic adenosine monophosphate-mediated signaling pathways in photodynamic injury of isolated crayfish neuron and satellite glial cells.

Journal: Journal of neuroscience research 20070301

Title: Insulin resistance index and counter-regulatory factors during olanzapine or risperidone administration in subjects with schizophrenia.

Journal: Schizophrenia research 20070101

Title: Relative risk of glucose elevation during antipsychotic exposure in a Veterans Administration population.

Journal: International clinical psychopharmacology 20070101

Title: Presumptive fluphenazine-induced hepatitis and urticaria in a horse.

Journal: Journal of veterinary internal medicine 20070101

Title: The neuroleptic drug, fluphenazine, blocks neuronal voltage-gated sodium channels.

Journal: Brain research 20060823

Title: Adverse extrapyramidal effects in four horse given fluphenazine decanoate.

Journal: Journal of the American Veterinary Medical Association 20060701

Title: Dopamine antagonist alters serum cortisol and prolactin secretion in lactating Holstein cows.

Journal: Journal of dairy science 20060601

Title: Series of seizures as a sign of development of recurrent malignant neuroleptic syndrome - a case report.

Journal: Psychiatria Danubina 20060601

Title: A randomized double-blind 12-week study of quetiapine, risperidone or fluphenazine on sexual functioning in people with schizophrenia.

Journal: Psychoneuroendocrinology 20060401

Title: Fluphenazine-induced extrapyramidal side effects in a horse.

Journal: The Veterinary clinics of North America. Equine practice 20060401

Title: Management of psychosis in Australian general practice.

Journal: Australian family physician 20060301

Title: Repeated antipsychotic drug exposure in developing rats: dopamine receptor effects.

Journal: Synapse (New York, N.Y.) 20060201

Title: In vitro phototoxicity of phenothiazines: involvement of stable UVA photolysis products formed in aqueous medium.

Journal: Chemical research in toxicology 20060101

Title: Antipsychotics produce locomotor impairment in larval zebrafish.

Journal: Neurotoxicology and teratology 20060101

Title: Differing effects of antipsychotic medications on substance abuse treatment patients with co-occurring psychotic and substance abuse disorders.

Journal: The American journal on addictions 20060101

Title: Risks versus benefits of different types of long-acting injectable antipsychotics.

Journal: The Journal of clinical psychiatry 20060101

Title: Performance of diadochokinetic movements in schizophrenic patients.

Journal: Schizophrenia research 20051115

Title: Calpain activation contributes to oxidative stress-induced pancreatic acinar cell injury.

Journal: Biochemical pharmacology 20051015

Title: Invited review: fluphenazine augments retinal oxidative stress.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20050801

Title: Fluphenazine-induced neuroleptic malignant syndrome in a schizophrenic patient.

Journal: The Annals of pharmacotherapy 20050601

Title: Importance of oral glucose tolerance test in patient with schizophrenia.

Journal: Psychiatria Danubina 20050601

Title: Mitochondria and plasma membrane as targets of UVA-induced toxicity of neuroleptic drugs fluphenazine, perphenazine and thioridazine.

Journal: The international journal of biochemistry & cell biology 20050401

Title: Anthrax toxin protective antigen: inhibition of channel function by chloroquine and related compounds and study of binding kinetics using the current noise analysis.

Journal: Biophysical journal 20050301

Title: Depot fluphenazine decanoate and enanthate for schizophrenia.

Journal: The Cochrane database of systematic reviews 20050125

Title: Thyroid function in treatment-resistant schizophrenia patients treated with quetiapine, risperidone, or fluphenazine.

Journal: The Journal of clinical psychiatry 20050101

Title: Densitometric high performance thin-layer chromatography identification and quantitative analysis of psychotropic drugs.

Journal: Journal of AOAC International 20050101

Title: Hyperprolactinemia affects spermiogenesis in adult male rats.

Journal: Journal of endocrinological investigation 20050101

Title: Second-generation antipsychotic drugs, olanzapine, quetiapine, and clozapine enhance neurite outgrowth in PC12 cells via PI3K/AKT, ERK, and pertussis toxin-sensitive pathways.

Journal: Journal of molecular neuroscience : MN 20050101

Title: Risperidone, quetiapine, and fluphenazine in the treatment of patients with therapy-refractory schizophrenia.

Journal: Clinical neuropharmacology 20050101

Title: [Fluphenazine decanoate overdose with no apparent adverse events].

Journal: Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria 20050101

Title: Comparison of the effect of the R2 phenothiazine ring substituent on fluphenazine and perphenazine interactions with cyclodextrins.

Journal: Acta poloniae pharmaceutica 20050101

Title: The impact of neuroleptic medication on seizure threshold and duration in electroconvulsive therapy.

Journal: Ideggyogyaszati szemle 20041120

Title: [Alterations of gait parameters under external cueing in schizophrenic patients: a switch study].

Journal: Psychiatrische Praxis 20041101

Title: Olanzapine versus fluphenazine in an open trial in patients with psychotic combat-related post-traumatic stress disorder.

Journal: Psychopharmacology 20041001

Title: Identification and characterization of the acidic pH binding sites for growth regulatory ligands of low density lipoprotein receptor-related protein-1.

Journal: The Journal of biological chemistry 20040910

Title: Identification of P-glycoprotein substrates and inhibitors among psychoactive compounds--implications for pharmacokinetics of selected substrates.

Journal: The Journal of pharmacy and pharmacology 20040801

Title: Circadian-dependent effect of melatonin on dopaminergic D2 antagonist-induced hypokinesia and agonist-induced stereotypies in rats.

Journal: Pharmacology, biochemistry, and behavior 20040801

Title: Long-acting injectable risperidone: safety and efficacy in stable patients switched from conventional depot antipsychotics.

Journal: International clinical psychopharmacology 20040701

Title: Mianserin for the rapid improvement of chronic akathisia in a schizophrenia patient.

Journal: European psychiatry : the journal of the Association of European Psychiatrists 20040601

Title: Distinct roles of Ca2+, calmodulin, and protein kinase C in H2O2-induced activation of ERK1/2, p38 MAPK, and protein kinase B signaling in vascular smooth muscle cells.

Journal: Antioxidants & redox signaling 20040401

Title: Double-blind, randomized comparison of olanzapine versus fluphenazine in the long-term treatment of schizophrenia.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20040301

Title: Flow and injection characteristics of pharmaceutical parenteral formulations using a micro-capillary rheometer.

Journal: International journal of pharmaceutics 20040211

Title: Efficacy and tolerability of quetiapine in poorly responsive, chronic schizophrenia.

Journal: Schizophrenia research 20040201

Title: Characterization of phenothiazine-induced apoptosis in neuroblastoma and glioma cell lines: clinical relevance and possible application for brain-derived tumors.

Journal: Journal of molecular neuroscience : MN 20040101

Title: Fluphenazine and its toxic maculopathy.

Journal: Ophthalmic research 20040101

Title: Calmodulin-myosin light chain kinase inhibition changes fibroblast-populated collagen lattice contraction, cell migration, focal adhesion formation, and wound contraction.

Journal: Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 20040101

Title: Carbamazepine for acute psychosis with EEG abnormalities.

Journal: Vojnosanitetski pregled 20040101

Title: Atypical (olanzapine) plus conventional (fluphenazine) neuroleptic treatment associated with the neuroleptic malignant syndrome.

Journal: Journal of clinical psychopharmacology 20031201

Title: Mechanism of C2-toxin inhibition by fluphenazine and related compounds: investigation of their binding kinetics to the C2II-channel using the current noise analysis.

Journal: Journal of molecular biology 20031024

Title: Homer1 proteins and AMPA receptors modulate cocaine-induced behavioural plasticity.

Journal: The European journal of neuroscience 20030901

Title: Clozapine as a first treatment for schizophrenia.

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Title: Cortisol as an indicator of dopaminergic effects on nicotine craving.

Journal: Human psychopharmacology 20030801

Title: Photosensitization of DNA strand breaks by three phenothiazine derivatives.

Journal: Chemical research in toxicology 20030501

Title: Antifertility effects of fluphenazine in adult male rats.

Journal: Journal of endocrinological investigation 20030401

Title: Augmentation of clozapine partial responders with conventional antipsychotics.

Journal: Schizophrenia research 20030301

Title: Clozapine and tardive dyskinesia.

Journal: The American journal of psychiatry 20030301

Title: Rehospitalization risk with second-generation and depot antipsychotics.

Journal: Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists 20030301

Title: Pretreatment with serotonin 5-HT(3) receptor antagonists produces no observable blockade of long-term motor sensitization to cocaine in rats.

Journal: Psychopharmacology 20030201

Title: Central administration of the neurotensin receptor antagonist SR48692 attenuates vacuous chewing movements in a rodent model of tardive dyskinesia.

Journal: Neuroscience 20030101

Title: Disturbed glucose metabolism among patients taking olanzapine and typical antipsychotics.

Journal: Psychopharmacology bulletin 20030101

Title: The effect of age on the pharmacological management of ambulatory patients treated with depot neuroleptic medications for schizophrenia and related psychotic disorders.

Journal: International journal of geriatric psychiatry 20021101

Title: Sexual side effects of novel antipsychotic medications.

Journal: Schizophrenia research 20020701

Title: Classical and atypical neuroleptics, and bone mineral density, in patients with schizophrenia.

Journal: The International journal of neuroscience 20020701

Title: Interaction of S100 proteins with the antiallergic drugs, olopatadine, amlexanox, and cromolyn: identification of putative drug binding sites on S100A1 protein.

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Title: Effects of atypical antipsychotics on vertebrate neuromuscular transmission.

Journal: Neuropharmacology 20020401

Title: Nanoparticles in plant extracts: influence of drugs on the formation of nanoparticles and precipitates in black tea infusions.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20020301

Title: Fluphenazine plasma level monitoring for patients receiving fluphenazine decanoate.

Journal: Schizophrenia research 20020101

Title: Protein kinase C increases 11beta-hydroxysteroid dehydrogenase oxidation and inhibits reduction in rat Leydig cells.

Journal: Journal of andrology 20020101

Title: Blockade of nigral and pallidal opioid receptors suppresses vacuous chewing movements in a rodent model of tardive dyskinesia.

Journal: Neuroscience 20020101

Title: Clinical outcome following neuroleptic discontinuation in patients with remitted recent-onset schizophrenia.

Journal: The American journal of psychiatry 20011101

Title: Smooth muscle cell response to mechanical injury involves intracellular calcium release and ERK1/ERK2 phosphorylation.

Journal: Experimental cell research 20010910

Title: Systemic relaxin in pregnant pony mares grazed on endophyte-infected fescue: effects of fluphenazine treatment.

Journal: Theriogenology 20010801

Title: [Persistence of bilateral pigmentary deposits in stromal cornea in a woman after a brief treatment with antidepressants].

Journal: Klinische Monatsblatter fur Augenheilkunde 20010401

Title: The stimulation of MAP kinase by 1,25(OH)(2)-vitamin D(3) in skeletal muscle cells is mediated by protein kinase C and calcium.

Journal: Molecular and cellular endocrinology 20010227

Title: Antimutagenic activity of fluphenazine in short-term tests.

Journal: Mutagenesis 20010101

Title: Inhibition of the type 1 inositol 1,4,5-trisphosphate-sensitive Ca2+ channel by calmodulin antagonists.

Journal: Cellular signalling 20010101

Title: Increased incidence of dyskinesias and other behavioral effects of re-exposure to neuroleptic treatment in social colonies of Cebus apella monkeys.

Journal: Psychopharmacology 20010101

Title: The influence of personality on nicotine craving: a hierarchical multivariate statistical prediction model.

Journal: Neuropsychobiology 20010101

Title: Neuroleptic effects on autonomic activity in schizophrenia: between-group and within-subject paradigms and comparisons with controls.

Journal: Schizophrenia bulletin 20010101

Title: Thrombocytopenia associated with clozapine and fluphenazine.

Journal: Nordic journal of psychiatry 20010101

Title: Fluphenazine levels during maintenance treatment of recent-onset schizophrenia: relation to side effects, psychosocial function and depression.

Journal: Psychopharmacology 20000301

Title: Pentadecapeptide BPC 157 attenuates disturbances induced by neuroleptics: the effect on catalepsy and gastric ulcers in mice and rats.

Journal: European journal of pharmacology 19990820

Title: The anticataleptic effect of 7-OH-DPAT: are dopamine D3 receptors involved?

Journal: Journal of neural transmission (Vienna, Austria : 1996) 19990101

Title: Dopamine depletion reorganizes projections from the nucleus accumbens and ventral pallidum that mediate opioid-induced motor activity.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 19981001

Title: Conventional psychotropic-induced tremor extinguished by olanzapine.

Journal: The American journal of psychiatry 19980801

Title: D2 dopamine antisense RNA expression vector, unlike haloperidol, produces long-term inhibition of D2 dopamine-mediated behaviors without causing Up-regulation of D2 dopamine receptors.

Journal: The Journal of pharmacology and experimental therapeutics 19980601

Title: Muscle rigidity induced by fluphenazine in rats is antagonized by L-DOPA, an antiparkinsonian drug.

Journal: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 19980601

Title: Attenuation of antipsychotic-induced hyperprolactinemia with clozapine.

Journal: Journal of child and adolescent psychopharmacology 19970101

Title: Fluphenazine decanoate causing atrioventricular block.

Journal: Indian heart journal 19960101

Title: An unusual effect of ECT on drug-induced parkinsonism and tardive dystonia.

Journal: Convulsive therapy 19951201

Title: D2 dopamine receptor antisense oligodeoxynucleotide inhibits the synthesis of a functional pool of D2 dopamine receptors.

Journal: Molecular pharmacology 19951001

Title: Differential effects of classical and newer antipsychotics on the hypermotility induced by two dose levels of D-amphetamine.

Journal: European journal of pharmacology 19950905

Title: Fluphenazine plasma levels, dosage, efficacy, and side effects.

Journal: The American journal of psychiatry 19950501

Title: A double-blind dose-reduction trial of fluphenazine decanoate for chronic, unstable schizophrenic patients.

Journal: The American journal of psychiatry 19941201

Title: Movement disorders in patients treated with long-acting injectable antipsychotic drugs.

Journal: American journal of hospital pharmacy 19940401

Title: Relation of plasma fluphenazine levels to treatment response and extrapyramidal side effects in first-episode schizophrenic patients.

Journal: The American journal of psychiatry 19940101

Title: Interaction between fluoxetine and neuroleptics.

Journal: The American journal of psychiatry 19930501

Title: Two cases of long term dopamine D2 receptor blockade after depot neuroleptics.

Journal: Journal of neural transmission. General section 19930101

Title: Positive and negative symptoms, depression and social disability in chronic schizophrenia: a comparative trial of bromperidol and fluphenazine decanoates.

Journal: International clinical psychopharmacology 19921101

Title: Incidence and correlates of acute extrapyramidal symptoms in first episode of schizophrenia.

Journal: Psychopharmacology bulletin 19920101

Title: Dopaminergic involvement in locomotion elicited from the ventral pallidum/substantia innominata.

Journal: Brain research 19910222

Title: Blockade of both D-1 and D-2 dopamine receptors may induce catalepsy in mice.

Journal: General pharmacology 19910101

Title: Fluphenazine dose, clinical response, and extrapyramidal symptoms during acute treatment.

Journal: Archives of general psychiatry 19900801

Title: Actions of ORG 5222 as a novel psychotropic agent.

Journal: Pharmacology, biochemistry, and behavior 19900301

Title: Behavioral and electroencephalographic effects of a depot type neuroleptic fluphenazine decanoate, in rats.

Journal: Journal of pharmacobio-dynamics 19891101

Title: Prolonged fever without extrapyramidal symptoms during neuroleptic treatment.

Journal: Journal of clinical psychopharmacology 19890601

Title: Drug-induced dystonia in young and elderly patients.

Journal: The American journal of psychiatry 19880701

Title: [Tardive dystonia--a case report on therapy and metaphylaxis].

Journal: Psychiatrie, Neurologie, und medizinische Psychologie 19880501

Title: [Repeated acute dystonia following administration of metoclopramide and fluphenazine].

Journal: Ugeskrift for laeger 19880314

Title: Effects of the 5-HT3 receptor antagonist, GR38032F, on raised dopaminergic activity in the mesolimbic system of the rat and marmoset brain.

Journal: British journal of pharmacology 19871201

Title: Unusual treatment response of a severe dystonia to diphenhydramine.

Journal: Annals of emergency medicine 19870601

Title: The Pisa syndrome during maintenance antipsychotic therapy.

Journal: The American journal of psychiatry 19861101

Title: A case of neuroleptic malignant syndrome in a mentally retarded adolescent.

Journal: Journal of adolescent health care : official publication of the Society for Adolescent Medicine 19861101

Title: Lithium potentiation of neuroleptic-related extrapyramidal side effects.

Journal: The American journal of psychiatry 19860701

Title: [Catatonia due to fluphenazine].

Journal: Harefuah 19860401

Title: [Long-term moditen-depot treatment of schizophrenic patients at a psychoneurology dispensary].

Journal: Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952) 19860101

Title: Catatonia associated with phenylpropanolamine overdose and fluphenazine treatment: case report.

Journal: The Journal of clinical psychiatry 19850701

Title: Costs and benefits of two doses of fluphenazine.

Journal: Archives of general psychiatry 19841101

Title: [Malignant neuroleptics syndrome].

Journal: Deutsche medizinische Wochenschrift (1946) 19840309

Title: Neuroleptic malignant syndrome.

Journal: The Medical journal of Australia 19840107

Title: Fluphenazine decanoate-induced cholestatic jaundice and thrombocytopenia.

Journal: Pharmacotherapy 19840101

Title: Management of a case of neuroleptic malignant syndrome with bromocriptine.

Journal: The American journal of psychiatry 19831201

Title: Treatment of the neuroleptic malignant syndrome with bromocriptine.

Journal: JAMA 19830701

Title: Neuroleptic malignant syndrome: successful treatment with dantrolene and bromocriptine.

Journal: Annals of neurology 19830701

Title: Propranolol, benztropine, fluphenazine decanoate, and delirium.

Journal: The American journal of psychiatry 19830501

Title: Psychotropic-induced sexual inhibition.

Journal: The American journal of psychiatry 19830401

Title: Neuroleptic malignant syndrome and malignant hyperthermia.

Journal: Lancet (London, England) 19830129

Title: Variation in oro-facial tardive dyskinesia during depot antipsychotic drug treatment.

Journal: Psychopharmacology 19830101

Title: A case of neuroleptic malignant syndrome successfully treated with amantadine.

Journal: The Journal of clinical psychiatry 19820901

Title: Lithium carbonate/fluphenazine decanoate producing irreversible brain damage.

Journal: Lancet (London, England) 19820731

Title: Catatonic-like syndrome during neuroleptic therapy.

Journal: Psychosomatics 19820701

Title: Fluphenazine enanthate and fluphenazine decanoate in the treatment of schizophrenic outpatients: extrapyramidal symptoms and therapeutic effect.

Journal: The American journal of psychiatry 19820301

Title: Development and prediction of postpsychotic depression in neuroleptic-treated schizophrenics.

Journal: Archives of general psychiatry 19820201

Title: Neuroleptic-induced seizures. An in vitro technique for assessing relative risk.

Journal: Archives of general psychiatry 19820201

Title: Catalepsy produced by long-acting neuroleptics, fluphenazine enanthate and fluphenazine decanoate, in mice.

Journal: Pharmacology 19820101

Title: Intrauterine effect of phenothiazines.

Journal: The Medical journal of Australia 19810418

Title: Stuttering: an unusual side effect of phenothiazines.

Journal: The American journal of psychiatry 19810301

Title: Extrapyramidal reaction to fluphenazine potentiated by thyrotoxicosis.

Journal: The American journal of psychiatry 19810201

Title: Fluphenazine pharmacokinetics and therapeutic response.

Journal: Psychopharmacology 19810101

Title: Neuroleptic-induced syndrome mimicking myasthenia gravis.

Journal: Psychosomatics 19810101

Title: behavior of rats and mice administered active metabolites of fluphenazine, 7-hydroxy-fluphenazine and fluphenazine-sulfoxide.

Journal: Archives internationales de pharmacodynamie et de therapie 19801101

Title: Water intoxication from fluphenazine therapy.

Journal: Italian journal of neurological sciences 19800601

Title: Patients at risk of developing severe side effects from depot fluphenazine treatment.

Journal: The American journal of psychiatry 19800201

Title: Depressive and extrapyramidal symptoms and clinical effects: a trial of fluphenazine versus flupenthixol in maintenance of schizophrenic out-patients.

Journal: The British journal of psychiatry : the journal of mental science 19791201

Title: Somnambulistic-like episodes secondary to combined lithium-neuroleptic treatment.

Journal: The British journal of psychiatry : the journal of mental science 19791101

Title: Endocrinological changes in patients with sexual dysfunction under long-term neuroleptic treatment.

Journal: Pharmakopsychiatrie, Neuro-Psychopharmakologie 19791101

Title: Fluphenazine enanthate in the outpatient treatment of late paraphrenia.

Journal: Journal of the American Geriatrics Society 19791001

Title: Iatrogenic morbidity in patients taking depot fluphenazine.

Journal: The American journal of psychiatry 19790701

Title: Sleep disturbance associated with fluphenazine HCl: a case report.

Journal: The American journal of psychiatry 19790701

Title: Delirium associated with combined fluphenazine-clonidine therapy.

Journal: The Journal of clinical psychiatry 19790501

Title: Ethopropazine and benztropine in neuroleptic-induced parkinsonism.

Journal: The Journal of clinical psychiatry 19790301

Title: Unwanted effects of fluphenazine enanthate and decanoate.

Journal: Lancet (London, England) 19790210

Title: Acute extrapyramidal reactions with fluphenazine hydrochloride and fluphenazine decanoate.

Journal: The American journal of psychiatry 19790201

Title: Neuroleptic malignant syndrome due to depot fluphenazine.

Journal: The Journal of clinical psychiatry 19790201

Title: Comparison of the incidence and severity of extrapyramidal side effects with fluphenazine enanthate and fluphenazine decanoate.

Journal: The American journal of psychiatry 19781201

Title: High vs standard dosage fluphenazine HCL in acute schizophrenia.

Journal: The Journal of clinical psychiatry 19781101

Title: Phenothiazine-induced dystonic reaction while swimming.

Journal: British medical journal 19781021

Title: Depot injections and tardive dyskinesia.

Journal: The British journal of psychiatry : the journal of mental science 19781001

Title: Neuropharmacological and behavioral evaluation of prostaglandin E2 and 11-thiol-11-desoxy prostaglandin E2 in the mouse and rat.

Journal: Psychopharmacology 19780531

Title: Double-blind therapeutic evaluation of fluspirilene compared with fluphenazine decanoate in chronic schizophrenics.

Journal: Acta psychiatrica Scandinavica 19780501

Title: The influence of alpha-adrenergic drugs on catalepsy induced by haloperidol or fluphenazine in rats.

Journal: Polish journal of pharmacology and pharmacy 19780101

Title: [Course of psychopathologic and extrapyramidal motor symptoms during long-term treatment of schizophrenic patients with psycholeptic drugs (author's transl)].

Journal: Arzneimittel-Forschung 19780101

Title: [Pharmacogenic depressive syndromes in the course of schizophrenic psychoses (author's transl)].

Journal: Arzneimittel-Forschung 19780101

Title: Catatonic reactions to high-potency neuroleptic drugs.

Journal: Archives of general psychiatry 19770801

Title: A comparison of piribedil, procyclidine and placebo in the control of phenothiazine-induced parkinsonism.

Journal: The British journal of psychiatry : the journal of mental science 19770601

Title: [Treatment of schizophrenic psychoses with Lyorodin].

Journal: Psychiatrie, Neurologie, und medizinische Psychologie 19770601

Title: Phenothiazine-induced bulbar palsy-like syndrome and sudden death.

Journal: The American journal of psychiatry 19770301

Title: Comparison of antipsychotic depot injections in the maintenance treatment of schizophrenia.

Journal: The British journal of psychiatry : the journal of mental science 19761101

Title: On the anticataleptic action of cyproheptadine.

Journal: Pharmacology, biochemistry, and behavior 19760801

Title: Letter: Parkinsonism induced by fluphenazine decanoate.

Journal: Lancet (London, England) 19760227

Title: A comparative trial of orphenadrine and tofenacin in the control of depression and extrapyramidal side-effects associated with fluphenazine decanoate therapy.

Journal: The Journal of international medical research 19760101

Title: [Complications of the treatment with long-acting neuroleptic preparations. Brain disease due to fluphenazine decanoate].

Journal: Acta neurologica 19760101

Title: Antiparkinsonian agents and fluphenazine decanoate.

Journal: The American journal of psychiatry 19760101

Title: The long-acting phenothiazines.

Journal: Archives of general psychiatry 19750701

Title: Drug-induced dystonia.

Journal: The American journal of psychiatry 19750501

Title: The behavioral pharmacology of butaclamol hydrochloride (AY-23,028), a new potent neuroleptic drug.

Journal: Psychopharmacologia 19750430

Title: Letter: Potentiation of tardive dyskinesia: possible drug interaction.

Journal: British medical journal 19750419

Title: Tardive dyskinesia treated with pimozide.

Journal: Journal of the neurological sciences 19750401

Title: Implications of phenothiazine side effects: a study of antiparkinsonian agents in an older population.

Journal: Acta psychiatrica Scandinavica 19750201

Title: A comparative trail of fluphenazine decanoate and flupenthixol decanoate.

Journal: Acta psychiatrica Scandinavica 19750201

Title: Tissue metabolites of trifluorperazine, fluphenazine, prochlorperazine, and perphenazine. Kinetics in chronic treatment.

Journal: Drug metabolism and disposition: the biological fate of chemicals 19750101

Title: Antagonistic effect of cyproheptadine on neuroleptic-induced catalepsy.

Journal: Pharmacology, biochemistry, and behavior 19750101

Title: The effect of 5-hydroxytrytamine synthesis inhibitors on neuroleptic-induced catalepsy in rats.

Journal: Archivum immunologiae et therapiae experimentalis 19750101

Title: Fluphenazine enanthate induced decompensations.

Journal: Psychosomatics 19750101

Title: Maintenance treatment of schizophrenia with long-acting fluphenazine.

Journal: Activitas nervosa superior 19740801

Title: Phenothiazine-induced decompensation.

Journal: Archives of general psychiatry 19740101

Title: Antiparkinsonian agents and depot phenothiazine.

Journal: The American journal of psychiatry 19740101

Title: Fluphenazine enanthate and fluphenazine decanoate: a comparison of their duration of action and motor side effects.

Journal: The American journal of psychiatry 19730701

Title: Depot phenothiazine treatment in acute psychosis: a sequential comparative clinical study.

Journal: The American journal of psychiatry 19730101

Title: Rigidity, hyperpyrexia and coma following fluphenazine enanthate.

Journal: Psychopharmacologia 19730101

Title: The therapeutic use of diazepam for akathisia.

Journal: Psychosomatics 19730101

Title: Amotivational syndrome.

Journal: Canadian Medical Association journal 19720819

Title: Parenteral long-acting phenothiazines.

Journal: British medical journal 19720325

Title: Benzhexol and side effects with long-acting fluphenazine therapy.

Journal: British medical journal 19720129

Title: Side effects of parenteral long-acting phenothiazines.

Journal: British medical journal 19720122

Title: A review of clinical studies with combinations of fluphenazine and nortriptyline.

Journal: Current medical research and opinion 19720101

Title: Institutional management of chronic schizophrenics with fluphenazine decanoate.

Journal: Diseases of the nervous system 19700901

Title: Greater than recommended drug dosages--some effects.

Journal: The American journal of psychiatry 19700601

Title: Treatment of resistant schizophrenics with extreme high dosage fluphenazine hydrochloride.

Journal: Psychosomatics 19700101

Title: Sudden death in phenothiazine therapy. (A clinicopathologic study of 12 cases).

Journal: The Psychiatric quarterly 19700101

Title: Acute phenothiazine dystonia.

Journal: Lancet (London, England) 19691213

Title: Severe depressive mood changes following slow-release intramuscular fluphenazine injection.

Journal: British medical journal 19690906

Title: Side-effects of phenothiazines.

Journal: British medical journal 19670401

Title: Drug-induced extrapyramidal symptoms: their incidence and treatment.

Journal: The American journal of psychiatry 19670101

Title: Dystonic reactions to phenothiazine derivatives.

Journal: Archives of disease in childhood 19661001

Title: A comparative study of two long acting phenothiazine preparations, fluphenazine-enanthate and fluphenazine-decanoate.

Journal: Psychopharmacologia 19660101

Title: [Psuedotetanus caused by neuroleptics. Description of a case caused by fluphenazine].

Journal: Archivio italiano di pediatria e puericoltura 19660101

Title: Trzeciak HI, et al. Behavioral effects of withdrawal of fluphenazine after long-term treatment. Arzneimittelforschung. 1976;26(9):1697-700.

Title: Whelpton R, Curry SH. Effect of 20, 6Methods for study of fluphenazine kinetics in man. J Pharm Pharmacol. 1976 Dec;28(12):869-73.

Title: Javaid JI, et al. Fluphenazine determination in human plasma by a sensitive gas chromatographic method using nitrogen detector. J Chromatogr Sci. 1981 Sep;19(9):439-43.

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Tags:146-56-5 Molecular Formula|146-56-5 MDL|146-56-5 SMILES|146-56-5 FLUPHENAZINE HYDROCHLORIDE