Home Amines 146-78-1
146-78-1,MFCD00866394
Catalog No.:AA001DJD

146-78-1 | (2R,3R,4S,5R)-2-(6-Amino-2-fluoro-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol

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1g
96%
in stock  
$34.00   $24.00
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  • Technical Information
  • Properties
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Technical Information
Catalog Number:
AA001DJD
Chemical Name:
(2R,3R,4S,5R)-2-(6-Amino-2-fluoro-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
CAS Number:
146-78-1
Molecular Formula:
C10H12FN5O4
Molecular Weight:
285.2318
MDL Number:
MFCD00866394
SMILES:
OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(F)nc2N
Properties
Properties
 
Form:
Solid  
MP:
240 °C (D)(lit.)  
Refractive Index:
-72 ° (C=0.1, EtOH)  
Storage:
Keep in dry area;Room Temperature;  

Computed Properties
 
Complexity:
367  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
4  
Heavy Atom Count:
20  
Hydrogen Bond Acceptor Count:
9  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
2  
XLogP3:
-0.6  

Literature

Title: Insights into phosphate cooperativity and influence of substrate modifications on binding and catalysis of hexameric purine nucleoside phosphorylases.

Journal: PloS one 20120101

Title: In vitro assessment of anticryptosporidial efficacy and cytotoxicity of adenosine analogues using a SYBR Green real-time PCR method.

Journal: The Journal of antimicrobial chemotherapy 20110301

Title: [The preparative method for 2-fluoroadenosine synthesis].

Journal: Bioorganicheskaia khimiia 20090101

Title: Characterization of an engineered human purine nucleoside phosphorylase fused to an anti-her2/neu single chain Fv for use in ADEPT.

Journal: Journal of experimental & clinical cancer research : CR 20090101

Title: Crystal structures of Mycobacterium tuberculosis S-adenosyl-L-homocysteine hydrolase in ternary complex with substrate and inhibitors.

Journal: Protein science : a publication of the Protein Society 20081201

Title: High resolution crystal structures of Mycobacterium tuberculosis adenosine kinase: insights into the mechanism and specificity of this novel prokaryotic enzyme.

Journal: The Journal of biological chemistry 20070914

Title: [(3)H]Adenine is a suitable radioligand for the labeling of G protein-coupled adenine receptors but shows high affinity to bacterial contaminations in buffer solutions.

Journal: Purinergic signalling 20070901

Title: Nicotinamide 2-fluoroadenine dinucleotide unmasks the NAD+ glycohydrolase activity of Aplysia californica adenosine 5'-diphosphate ribosyl cyclase.

Journal: Biochemistry 20070403

Title: Biodistribution and PET imaging of [(18)F]-fluoroadenosine derivatives.

Journal: Nuclear medicine and biology 20070401

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Identification of a subversive substrate of Trichomonas vaginalis purine nucleoside phosphorylase and the crystal structure of the enzyme-substrate complex.

Journal: The Journal of biological chemistry 20050610

Title: Partial agonists for A(3) adenosine receptors.

Journal: Current topics in medicinal chemistry 20040101

Title: Stereoselective synthesis and antiviral activity of D-2',3'-didehydro-2',3'-dideoxy-2'-fluoro-4'-thionucleosides.

Journal: Journal of medicinal chemistry 20021024

Title: Structural determinants of A(3) adenosine receptor activation: nucleoside ligands at the agonist/antagonist boundary.

Journal: Journal of medicinal chemistry 20020926

Title: Purine analogs as potential anticytomegalovirus agents.

Journal: Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 19690901

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Tags:146-78-1 Molecular Formula|146-78-1 MDL|146-78-1 SMILES|146-78-1 (2R,3R,4S,5R)-2-(6-Amino-2-fluoro-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol