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Home Fluorides 1467093-03-3
1467093-03-3,MFCD30489411
Catalog No.:AA01EO43

1467093-03-3 | N-(5-(3-(7-(3-Fluorophenyl)-3H-imidazo[4,5-c]pyridin-2-yl)-1H-indazol-5-yl)pyridin-3-yl)-3-methylbutanamide

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
97%
in stock  
$26.00   $18.00
- +
5mg
97%
in stock  
$110.00   $77.00
- +
10mg
97%
in stock  
$152.00   $107.00
- +
25mg
97%
in stock  
$211.00   $148.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA01EO43
Chemical Name:
N-(5-(3-(7-(3-Fluorophenyl)-3H-imidazo[4,5-c]pyridin-2-yl)-1H-indazol-5-yl)pyridin-3-yl)-3-methylbutanamide
CAS Number:
1467093-03-3
Molecular Formula:
C29H24FN7O
Molecular Weight:
505.5456
MDL Number:
MFCD30489411
SMILES:
CC(CC(=O)Nc1cncc(c1)c1ccc2c(c1)c(n[nH]2)c1nc2c([nH]1)c(cnc2)c1cccc(c1)F)C
Properties
Computed Properties
 
Complexity:
816  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
38  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
6  
XLogP3:
4.5  

Downstream Synthesis Route
N-(5-(3-(7-(3-fluorophenyl)-3H-imidazo4,5-cpyridin-2-yl)-1-trityl-1H-indazol-5-yl)pyridin-3-yl)-3-methylbutanamide 
  1467093-03-3 

[1]CurrentPatentAssignee:BIOSPLICETHERAPEUTICSINC-US2017/349584,2017,A1Locationinpatent:Paragraph0398;0403;0404;0407;0408-0414

C27H19BrN2O 
  1467093-03-3 

[1]CurrentPatentAssignee:BIOSPLICETHERAPEUTICSINC-US2017/349584,2017,A1

1214358-61-8   
N-(5-(3-formyl-1-trityl-1H-indazol-5-yl)pyridin-3-yl)-3-methylbutanamide 
  1467093-03-3 

[1]CurrentPatentAssignee:BIOSPLICETHERAPEUTICSINC-US2017/349584,2017,A1

5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-trityl-1H-indazole-3-carbaldehyde 
  1467093-03-3 

[1]CurrentPatentAssignee:BIOSPLICETHERAPEUTICSINC-US2017/349584,2017,A1

Literature

Title: A novel Wnt pathway inhibitor, SM04690, for the treatment of moderate to severe osteoarthritis of the knee: results of a 24-week, randomized, controlled, phase 1 study.

Journal: Osteoarthritis and cartilage 20171001

Title: WNT1-induced Secreted Protein-1 (WISP1), a Novel Regulator of Bone Turnover and Wnt Signaling.

Journal: The Journal of biological chemistry 20150529

Title: Involvement of the Wnt signaling pathway in experimental and human osteoarthritis: prominent role of Wnt-induced signaling protein 1.

Journal: Arthritis and rheumatism 20090201

Title: Wnt influence on chondrocyte differentiation and cartilage function.

Journal: DNA and cell biology 20050701

Title: Deshmukh V, et al. A small-molecule inhibitor of the Wnt pathway (SM04690) as a potential disease modifying agent for the treatment of osteoarthritis of the knee. Osteoarthritis Cartilage. 2018 Jan;26(1):18-27.

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Tags:1467093-03-3 Molecular Formula|1467093-03-3 MDL|1467093-03-3 SMILES|1467093-03-3 N-(5-(3-(7-(3-Fluorophenyl)-3H-imidazo[4,5-c]pyridin-2-yl)-1H-indazol-5-yl)pyridin-3-yl)-3-methylbutanamide