Title: 5-Lipoxygenase-activating protein (FLAP) inhibitors. Part 4: development of 3-[3-tert-butylsulfanyl-1-[4-(6-ethoxypyridin-3-yl)benzyl]-5-(5-methylpyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethylpropionic acid (AM803), a potent, oral, once daily FLAP inhibitor.
Journal: Journal of medicinal chemistry 20111208
Title: MK591, a leukotriene biosynthesis inhibitor, induces apoptosis in prostate cancer cells: synergistic action with LY294002, an inhibitor of phosphatidylinositol 3'-kinase.
Journal: Cancer letters 20100528
Title: Effect of 5-lipoxygenase inhibitor MK591 on early molecular and signaling events induced by staphylococcal enterotoxin B in human peripheral blood mononuclear cells.
Journal: The FEBS journal 20080601
Title: Substituted 2,2-bisaryl-bicycloheptanes as novel and potent inhibitors of 5-lipoxygenase activating protein.
Journal: Bioorganic & medicinal chemistry letters 20080315
Title: Angiotensin II-induced abdominal aortic aneurysm occurs independently of the 5-lipoxygenase pathway in apolipoprotein E-deficient mice.
Journal: Prostaglandins & other lipid mediators 20070801
Title: Crystal structure of inhibitor-bound human 5-lipoxygenase-activating protein.
Journal: Science (New York, N.Y.) 20070727
Title: Montelukast regulates eosinophil protease activity through a leukotriene-independent mechanism.
Journal: The Journal of allergy and clinical immunology 20060701
Title: Arachidonic acid activates phospholipase D in human neutrophils; essential role of endogenous leukotriene B4 and inhibition by adenosine A2A receptor engagement.
Journal: Journal of leukocyte biology 20030401
Title: Role of 5-lipoxygenase products in the local accumulation of neutrophils in dermal inflammation in the rabbit.
Journal: Journal of immunology (Baltimore, Md. : 1950) 19990915
Title: Assessment of the in vivo biochemical efficacy of orally active leukotriene biosynthesis inhibitors.
Journal: Agents and actions 19930901
Title: Mendis C, et al. Effect of 5-lipoxygenase inhibitor MK591 on early molecular and signaling events induced by staphylococcal enterotoxin B in human peripheral blood mononuclear cells. FEBS J. 2008 Jun;275(12):3088-98.
Title: Sarveswaran S, et al. MK591, a leukotriene biosynthesis inhibitor, induces apoptosis in prostate cancer cells: synergistic action with LY294002, an inhibitor of phosphatidylinositol 3'-kinase. Cancer Lett. 2010 May 28;291(2):167-76.
Title: Park MS, et al. 5-Lipoxygenase-activating protein (FLAP) inhibitor MK-0591 prevents aberrant alveolarization in newborn mice exposed to 85% oxygen in a dose- and time-dependent manner. Lung. 2011 Feb;189(1):43-50.
Title: Chu J, et al. Involvement of 5-lipoxygenase activating protein in the amyloidotic phenotype of an Alzheimer's disease mouse model. J Neuroinflammation. 2012 Jun 14;9:127.
