Home Amines 147116-67-4
147116-67-4,MFCD25541735
Catalog No.:AA001EJ4

147116-67-4 | 1-Azabicyclo[2.2.2]octan-3-amine, N-[[5-(1,1-dimethylethyl)-2-methoxyphenyl]methyl]-2-(diphenylmethyl)-, (2S,3S)-

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1mg
≥98%
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$50.00   $35.00
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100mg
98%
in stock  
$86.00   $60.00
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250mg
98%
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$102.00   $72.00
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1g
98%
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5g
98%
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA001EJ4
Chemical Name:
1-Azabicyclo[2.2.2]octan-3-amine, N-[[5-(1,1-dimethylethyl)-2-methoxyphenyl]methyl]-2-(diphenylmethyl)-, (2S,3S)-
CAS Number:
147116-67-4
Molecular Formula:
C32H40N2O
Molecular Weight:
468.6728
MDL Number:
MFCD25541735
SMILES:
COc1ccc(cc1CN[C@H]1C2CCN([C@H]1C(c1ccccc1)c1ccccc1)CC2)C(C)(C)C
Properties
Computed Properties
 
Complexity:
620  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Heavy Atom Count:
35  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
8  
XLogP3:
7  

Downstream Synthesis Route

[1]CurrentPatentAssignee:PFIZERINC-WO2005/75473,2005,A1Locationinpatent:Page/Pagecolumn16;22-23

(2-diphenylmethyl-1-azabicyclo2.2.2oct-3-yl)-benzylamine 
  85943-26-6    147116-67-4 

[1]CurrentPatentAssignee:WISDOMPHARMACEUTICAL-CN110713488,2020,ALocationinpatent:Paragraph0015

Literature

Title: Effect of epidural and intravenous use of the neurokinin-1 (NK-1) receptor antagonist maropitant on the sevoflurane minimum alveolar concentration (MAC) in dogs.

Journal: Veterinary anaesthesia and analgesia 20120301

Title: In vivo assessment of antiemetic drugs and mechanism of lycorine-induced nausea and emesis.

Journal: Archives of toxicology 20111201

Title: Effect of maropitant, a neurokinin 1 receptor antagonist, on anesthetic requirements during noxious visceral stimulation of the ovary in dogs.

Journal: American journal of veterinary research 20111201

Title: The use of maropitant to prevent vomiting induced by epidural administration of preservative free morphine through an epidural catheter in a dog.

Journal: Veterinary anaesthesia and analgesia 20110901

Title: Phase I evaluation of STA-1474, a prodrug of the novel HSP90 inhibitor ganetespib, in dogs with spontaneous cancer.

Journal: PloS one 20110101

Title: Acute vomiting in cats: rational treatment selection.

Journal: Journal of feline medicine and surgery 20100301

Title: Acute pancreatitis attributed to dietary indiscretion in a female mixed breed canine.

Journal: The Canadian veterinary journal = La revue veterinaire canadienne 20100201

Title: Efficacy of maropitant in the prevention of delayed vomiting associated with administration of doxorubicin to dogs.

Journal: Journal of veterinary internal medicine 20100101

Title: Effect of refrigeration of the antiemetic Cerenia (maropitant) on pain on injection.

Journal: Veterinary therapeutics : research in applied veterinary medicine 20090101

Title: Efficacy and safety of maropitant, a selective neurokinin 1 receptor antagonist, in two randomized clinical trials for prevention of vomiting due to motion sickness in dogs.

Journal: Journal of veterinary pharmacology and therapeutics 20081201

Title: Comparative efficacy of maropitant and selected drugs in preventing emesis induced by centrally or peripherally acting emetogens in dogs.

Journal: Journal of veterinary pharmacology and therapeutics 20081201

Title: Safety and efficacy of injectable and oral maropitant, a selective neurokinin 1 receptor antagonist, in a randomized clinical trial for treatment of vomiting in dogs.

Journal: Journal of veterinary pharmacology and therapeutics 20081201

Title: Safety, pharmacokinetics and use of the novel NK-1 receptor antagonist maropitant (Cerenia) for the prevention of emesis and motion sickness in cats.

Journal: Journal of veterinary pharmacology and therapeutics 20080601

Title: Efficacy of maropitant for preventing vomiting associated with motion sickness in dogs.

Journal: The Veterinary record 20070929

Title: The neurokinin-1 antagonist activity of maropitant, an antiemetic drug for dogs, in a gerbil model.

Journal: Journal of veterinary pharmacology and therapeutics 20070801

Title: The pharmacokinetics of maropitant, a novel neurokinin type-1 receptor antagonist, in dogs.

Journal: Journal of veterinary pharmacology and therapeutics 20070801

Title: [New antiemetics: maropitant citrate].

Journal: Tijdschrift voor diergeneeskunde 20070515

Title: Efficacy of injectable maropitant (Cerenia) in a randomized clinical trial for prevention and treatment of cisplatin-induced emesis in dogs presented as veterinary patients.

Journal: Veterinary and comparative oncology 20070301

Title: The anti-emetic efficacy of maropitant (Cerenia) in the treatment of ongoing emesis caused by a wide range of underlying clinical aetiologies in canine patients in Europe.

Journal: The Journal of small animal practice 20070201

Title: Efficacy of maropitant for treatment and prevention of emesis caused by intravenous infusion of cisplatin in dogs.

Journal: American journal of veterinary research 20070101

Title: Hay Kraus BL. Efficacy of maropitant in preventing vomiting in dogs premedicated with hydromorphone. Vet Anaesth Analg. 2013 Jan;40(1):28-34.

Title: Lesman SP, Boucher JF, Grover GS, et al. The pharmacokinetics of maropitant citrate dosed orally to dogs at 2 mg/kg and 8 mg/kg once daily for 14 days consecutive days. J Vet Pharmacol Ther. 2012 Nov 20.

Title: Alvillar BM, Boscan P, Mama KR, et al. Effect of epidural and intravenous use of the neurokinin-1 (NK-1) receptor antagonist maropitant on the sevoflurane minimum alveolar concentration (MAC) in dogs. Vet Anaesth Analg. 2012 Mar;39(2):201-5.

Title: Ramsey DS, Kincaid K, Watkins JA et al. Safety and efficacy of injectable and oral maropitant, a selective neurokinin 1 receptor antagonist, in a randomized clinical trial for treatment of vomiting in dogs. J Vet Pharmacol Ther. 2008 Dec;31(6):538-43. doi: 10.1111/j.1365-2885.2008.00992.x.

Title: Benchaoui HA, Cox SR, Schneider RP et al. The pharmacokinetics of maropitant, a novel neurokinin type-1 receptor antagonist, in dogs. J Vet Pharmacol Ther. 2007 Aug;30(4):336-44.

Title: Maropitant

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SDS
Tags:147116-67-4 Molecular Formula|147116-67-4 MDL|147116-67-4 SMILES|147116-67-4 1-Azabicyclo[2.2.2]octan-3-amine, N-[[5-(1,1-dimethylethyl)-2-methoxyphenyl]methyl]-2-(diphenylmethyl)-, (2S,3S)-