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147444-03-9,MFCD00929109
Catalog No.:AA00AOQF

147444-03-9 | pyripyropene A

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1mg
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  • Technical Information
  • Properties
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Technical Information
Catalog Number:
AA00AOQF
Chemical Name:
pyripyropene A
CAS Number:
147444-03-9
Molecular Formula:
C31H35NO10
Molecular Weight:
581.6103
MDL Number:
MFCD00929109
SMILES:
CC(=O)OCC1(C)C(CCC2(C1C=C(OC(=O)C)C1(C2C(=C2C(=CC(OC2=O)c2cccnc2)O1)O)C)C)OC(=O)C
Properties
Computed Properties
 
Complexity:
1230  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
8  
Heavy Atom Count:
42  
Hydrogen Bond Acceptor Count:
11  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
8  
XLogP3:
2.5  

Literature

Title: Pyripyropene A, an acyl-coenzyme A:cholesterol acyltransferase 2-selective inhibitor, attenuates hypercholesterolemia and atherosclerosis in murine models of hyperlipidemia.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20110501

Title: Pyripyropenes, fungal sesquiterpenes conjugated with alpha-pyrone and pyridine moieties, exhibits anti-angiogenic activity against human umbilical vein endothelial cells.

Journal: Biological & pharmaceutical bulletin 20090701

Title: Penicillium griseofulvum F1959, high-production strain of pyripyropene a, specific inhibitor of acyl-CoA: cholesterol acyltransferase 2.

Journal: Journal of microbiology and biotechnology 20081001

Title: Selectivity of microbial acyl-CoA: cholesterol acyltransferase inhibitors toward isozymes.

Journal: The Journal of antibiotics 20070101

Title: Exploiting PdII and TiIII chemistry to obtain gamma-dioxygenated terpenoids: synthesis of rostratone and novel approaches to aphidicolin and pyripyropene A.

Journal: The Journal of organic chemistry 20051014

Title: ACAT2 is localized to hepatocytes and is the major cholesterol-esterifying enzyme in human liver.

Journal: Circulation 20041005

Title: Identification of ACAT1- and ACAT2-specific inhibitors using a novel, cell-based fluorescence assay: individual ACAT uniqueness.

Journal: Journal of lipid research 20040201

Title: [Synthetic studies of microbial natural products from microorganisms].

Journal: The Japanese journal of antibiotics 20030201

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