Home Amines 1476-52-4
1476-52-4,MFCD00871808
Catalog No.:AA001EXV

1476-52-4 | 1,4-Pentanediamine, N4-(7-chloro-4-quinolinyl)-N1-ethyl-

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥95%
in stock  
$173.00   $121.00
- +
5mg
≥95%
in stock  
$605.00   $423.00
- +
10mg
≥95%
in stock  
$1,032.00   $722.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA001EXV
Chemical Name:
1,4-Pentanediamine, N4-(7-chloro-4-quinolinyl)-N1-ethyl-
CAS Number:
1476-52-4
Molecular Formula:
C16H22ClN3
Molecular Weight:
291.8190
MDL Number:
MFCD00871808
SMILES:
CCNCCCC(Nc1ccnc2c1ccc(c2)Cl)C
NSC Number:
13254
Properties
Computed Properties
 
Complexity:
274  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
20  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
7  
Undefined Atom Stereocenter Count:
1  
XLogP3:
3.8  

Literature

Title: HPLC with ultraviolet detection for the determination of chloroquine and desethylchloroquine in whole blood and finger-prick capillary blood dried on filter paper.

Journal: Journal of pharmaceutical and biomedical analysis 20110715

Title: Relationship between blood hydroxychloroquine and desethylchloroquine concentrations and cigarette smoking in treated patients with connective tissue diseases.

Journal: Annals of the rheumatic diseases 20071101

Title: Stereoselective determination of hydroxychloro-quine and its major metabolites in human urine by solid-phase microextraction and HPLC.

Journal: Journal of separation science 20071001

Title: Simultaneous determination of monodesethylchloroquine, chloroquine, cycloguanil and proguanil on dried blood spots by reverse-phase liquid chromatography.

Journal: Journal of pharmaceutical and biomedical analysis 20070219

Title: An improved high-performance liquid chromatographic determination of chloroquine and its major metabolite, desethylchloroquine, in human plasma.

Journal: European journal of drug metabolism and pharmacokinetics 20060101

Title: In vitro metabolism of chloroquine: identification of CYP2C8, CYP3A4, and CYP2D6 as the main isoforms catalyzing N-desethylchloroquine formation.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20030601

Title: Comparison of the in-vitro activity of amodiaquine and its main metabolite, monodesethyl-amodiaquine, in Plasmodium falciparum.

Journal: Wiener klinische Wochenschrift 20030101

Title: Hydroxychloroquine concentration-response relationships in patients with rheumatoid arthritis.

Journal: Arthritis and rheumatism 20020601

Title: Application of higher throughput screening (HTS) inhibition assays to evaluate the interaction of antiparasitic drugs with cytochrome P450s.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20010101

Title: Chloroquine treatment of severe malaria in children. Pharmacokinetics, toxicity, and new dosage recommendations.

Journal: The New England journal of medicine 19881208

Title: Ajayi FO, et al. Comparison of the partitioning in vitro of chloroquine and its desethyl metabolites between the erythrocytes and plasma of healthy subjects and those with falciparum malaria. Afr J Med Med Sci. 1989 Jun;18(2):95-100.

Title: Said A, et al. Chloroquine promotes IL-17 production by CD4+ T cells via p38-dependent IL-23 release by monocyte-derived Langerhans-like cells. J Immunol. 2014 Dec 15;193(12):6135-43.

Title: Vodicka P, et al. Assessment of chloroquine treatment for modulating autophagy flux in brain of WT and HD mice. J Huntingtons Dis. 2014;3(2):159-74.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Tags:1476-52-4 Molecular Formula|1476-52-4 MDL|1476-52-4 SMILES|1476-52-4 1,4-Pentanediamine, N4-(7-chloro-4-quinolinyl)-N1-ethyl-