Home Other Building Blocks 147776-06-5
147776-06-5,MFCD09959710
Catalog No.:AA001F3S

147776-06-5 | L 161982

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Purity
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1mg
≥95%
in stock  
$53.00   $37.00
- +
5mg
≥95%
in stock  
$230.00   $161.00
- +
10mg
≥95%
in stock  
$430.00   $301.00
- +
25mg
≥95%
in stock  
$1,006.00   $704.00
- +
50mg
≥98%
in stock  
$1,432.00   $1,003.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA001F3S
Chemical Name:
L 161982
CAS Number:
147776-06-5
Molecular Formula:
C32H29F3N4O4S2
Molecular Weight:
654.7223
MDL Number:
MFCD09959710
SMILES:
CCCCc1nn(c(=O)n1Cc1ccc(cc1)c1ccccc1S(=O)(=O)NC(=O)c1sccc1C)c1ccccc1C(F)(F)F
Properties
Computed Properties
 
Complexity:
1190  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
45  
Hydrogen Bond Acceptor Count:
9  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
10  
XLogP3:
7.3  

Literature

Title: Role of hypoxia-inducible factor 1, α subunit and cAMP-response element binding protein 1 in synergistic release of interleukin 8 by prostaglandin E2 and nickel in lung fibroblasts.

Journal: American journal of respiratory cell and molecular biology 20130701

Title: Autocrine prostaglandin E2 signaling promotes tumor cell survival and proliferation in childhood neuroblastoma.

Journal: PloS one 20120101

Title: Lubiprostone targets prostanoid EP₄ receptors in ovine airways.

Journal: British journal of pharmacology 20110101

Title: The role of PGE2 receptor EP4 in pathologic ocular angiogenesis.

Journal: Investigative ophthalmology & visual science 20091101

Title: Prostaglandin E2 glycerol ester, an endogenous COX-2 metabolite of 2-arachidonoylglycerol, induces hyperalgesia and modulates NFkappaB activity.

Journal: British journal of pharmacology 20080401

Title: Renal sympathetic nerve activity modulates afferent renal nerve activity by PGE2-dependent activation of alpha1- and alpha2-adrenoceptors on renal sensory nerve fibers.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20071001

Title: The EP4 receptor antagonist, L-161,982, blocks prostaglandin E2-induced signal transduction and cell proliferation in HCA-7 colon cancer cells.

Journal: Experimental cell research 20070815

Title: Prostaglandin E(2) protects human lung fibroblasts from cigarette smoke extract-induced apoptosis via EP(2) receptor activation.

Journal: Journal of cellular physiology 20070101

Title: Prostaglandin E2 promotes cell survival of glomerular epithelial cells via the EP4 receptor.

Journal: American journal of physiology. Renal physiology 20060601

Title: Role of periaqueductal grey prostaglandin receptors in formalin-induced hyperalgesia.

Journal: European journal of pharmacology 20060113

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