Home Fluorides 1478-61-1
1478-61-1,MFCD00000439
Catalog No.:AA003KAU

1478-61-1 | 2,2-Bis(4-hydroxyphenyl)hexafluoropropane

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5g
98%
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$6.00   $4.00
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10g
98%
in stock  
$7.00   $5.00
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25g
95%
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$15.00   $10.00
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100g
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500g
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  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA003KAU
Chemical Name:
2,2-Bis(4-hydroxyphenyl)hexafluoropropane
CAS Number:
1478-61-1
Molecular Formula:
C15H10F6O2
Molecular Weight:
336.2291
MDL Number:
MFCD00000439
SMILES:
FC(C(C(F)(F)F)(c1ccc(cc1)O)c1ccc(cc1)O)(F)F
NSC Number:
152522
Properties
Properties
 
BP:
400°C at 760 mmHg  
Form:
Solid  
MP:
160-163 °C(lit.)  
Storage:
Inert atmosphere;Room Temperature;  

Computed Properties
 
Complexity:
352  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
23  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
2  
XLogP3:
4.5  

Literature

Title: Effects of bisphenol analogs on thyroid endocrine system and possible interaction with 17β-estradiol using GH3 cells.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20181201

Title: Mechanism of bisphenol AF-induced progesterone inhibition in human chorionic gonadotrophin-stimulated mouse Leydig tumor cell line (mLTC-1) cells.

Journal: Environmental toxicology 20180601

Title: Transcriptomic and phenotypic profiling in developing zebrafish exposed to thyroid hormone receptor agonists.

Journal: Reproductive toxicology (Elmsford, N.Y.) 20180401

Title: Estrogenicity of halogenated bisphenol A: in vitro and in silico investigations.

Journal: Archives of toxicology 20180301

Title: Agonistic effects of diverse xenobiotics on the constitutive androstane receptor as detected in a recombinant yeast-cell assay.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20180201

Title: Binding interactions of halogenated bisphenol A with mouse PPARα: In vitro investigation and molecular dynamics simulation.

Journal: Toxicology letters 20180201

Title: Differential in Vitro Biological Action, Coregulator Interactions, and Molecular Dynamic Analysis of Bisphenol A (BPA), BPAF, and BPS Ligand-ERα Complexes.

Journal: Environmental health perspectives 20180101

Title: Bisphenol AF as an activator of human estrogen receptor β1 (ERβ1) in breast cancer cell lines.

Journal: The Journal of toxicological sciences 20180101

Title: Bisphenol AF negatively affects oocyte maturation of mouse in vitro through increasing oxidative stress and DNA damage.

Journal: Chemico-biological interactions 20171225

Title: The in vitro comparative study of the effect of BPA, BPS, BPF and BPAF on human erythrocyte membrane; perturbations in membrane fluidity, alterations in conformational state and damage to proteins, changes in ATP level and Na(+)/K(+) ATPase and AChE activities.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20171201

Title: Acute Toxicity, Teratogenic, and Estrogenic Effects of Bisphenol A and Its Alternative Replacements Bisphenol S, Bisphenol F, and Bisphenol AF in Zebrafish Embryo-Larvae.

Journal: Environmental science & technology 20171107

Title: Bisphenol AF and Bisphenol B Exert Higher Estrogenic Effects than Bisphenol A via G Protein-Coupled Estrogen Receptor Pathway.

Journal: Environmental science & technology 20171003

Title: Binding of bisphenol A, bisphenol AF, and bisphenol S on the androgen receptor: Coregulator recruitment and stimulation of potential interaction sites.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20171001

Title: Editor's Highlight: Transcriptome Profiling Reveals Bisphenol A Alternatives Activate Estrogen Receptor Alpha in Human Breast Cancer Cells.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20170801

Title: Bisphenol A, bisphenol S, bisphenol F and bisphenol AF induce different oxidative stress and damage in human red blood cells (in vitro study).

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20170601

Title: Differential Activation of a Mouse Estrogen Receptor β Isoform (mERβ2) with Endocrine-Disrupting Chemicals (EDCs).

Journal: Environmental health perspectives 20170401

Title: Thyroid hormone disrupting potentials of bisphenol A and its analogues - in vitro comparison study employing rat pituitary (GH3) and thyroid follicular (FRTL-5) cells.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20170401

Title: In vitro and in silico assessment of the structure-dependent binding of bisphenol analogues to glucocorticoid receptor.

Journal: Analytical and bioanalytical chemistry 20170301

Title: Bisphenol AF as an Inducer of Estrogen Receptor β (ERβ): Evidence for Anti-estrogenic Effects at Higher Concentrations in Human Breast Cancer Cells.

Journal: Biological & pharmaceutical bulletin 20170101

Title: Predicting anti-androgenic activity of bisphenols using molecular docking and quantitative structure-activity relationships.

Journal: Chemosphere 20161101

Title: Gestational and lactational exposure to bisphenol AF in maternal rats increases testosterone levels in 23-day-old male offspring.

Journal: Chemosphere 20161101

Title: Exposure to Bisphenol AF disrupts sex hormone levels and vitellogenin expression in zebrafish.

Journal: Environmental toxicology 20160301

Title: Effects of bisphenol analogues on steroidogenic gene expression and hormone synthesis in H295R cells.

Journal: Chemosphere 20160301

Title: Estrogenic Effects of Several BPA Analogs in the Developing Zebrafish Brain.

Journal: Frontiers in neuroscience 20160101

Title: Bisphenol AF stimulates transcription and secretion of C-X-C chemokine ligand 12 to promote proliferation of cultured T47D breast cancer cells.

Journal: Toxicology 20151202

Title: In vivo and in silico analyses of estrogenic potential of bisphenol analogs in medaka (Oryzias latipes) and common carp (Cyprinus carpio).

Journal: Ecotoxicology and environmental safety 20151001

Title: Genome-wide gene expression profiling of low-dose, long-term exposure of human osteosarcoma cells to bisphenol A and its analogs bisphenols AF and S.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20150801

Title: Long-term effects of bisphenol AF (BPAF) on hormonal balance and genes of hypothalamus-pituitary-gonad axis and liver of zebrafish (Danio rerio), and the impact on offspring.

Journal: Chemosphere 20150601

Title: Profiling of the Tox21 10K compound library for agonists and antagonists of the estrogen receptor alpha signaling pathway.

Journal: Scientific reports 20140101

Title: Bioactivation of bisphenol A and its analogs (BPF, BPAF, BPZ and DMBPA) in human liver microsomes.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20130601

Title: Bisphenol A affects androgen receptor function via multiple mechanisms.

Journal: Chemico-biological interactions 20130525

Title: Biotransformation of bisphenol AF to its major glucuronide metabolite reduces estrogenic activity.

Journal: PloS one 20130101

Title: Bisphenol AF may cause testosterone reduction by directly affecting testis function in adult male rats.

Journal: Toxicology letters 20120601

Title: 5,7,13,15-Tetra-oxo-2,2,10,10-tetra-kis-(trifluoro-meth-yl)-4,8,12,16-tetra-oxa-1(1,4),3(1,4),6(1,2),9(1,4),11(1,4),14(1,2)-hexa-benzenahexa-deca-phane tetra-hydro-furan monosolvate.

Journal: Acta crystallographica. Section E, Structure reports online 20120401

Title: Endocrine-mediated effects of 4,4'-(hexafluoroisopropylidene)diphenol in SD rats, based on a subacute oral toxicity study.

Journal: Archives of toxicology 20120101

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Bisphenol AF is a full agonist for the estrogen receptor ERalpha but a highly specific antagonist for ERbeta.

Journal: Environmental health perspectives 20100901

Title: Development of a molecularly imprinted polymer for selective extraction of bisphenol A in water samples.

Journal: Journal of separation science 20100601

Title: 1,1,1,3,3,3-Hexafluoro-2,2-bis-[4-(4-nitro-phen-oxy)phen-yl]propane.

Journal: Acta crystallographica. Section E, Structure reports online 20080801

Title: Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods.

Journal: Journal of molecular graphics & modelling 20061101

Title: Comparison of the reporter gene assay for ER-alpha antagonists with the immature rat uterotrophic assay of 10 chemicals.

Journal: Toxicology letters 20030430

Title: Measurement of estrogenic activity of chemicals for the development of new dental polymers.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20010101

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Tags:1478-61-1 Molecular Formula|1478-61-1 MDL|1478-61-1 SMILES|1478-61-1 2,2-Bis(4-hydroxyphenyl)hexafluoropropane