Home Other Building Blocks 1481677-78-4
1481677-78-4,MFCD28044322
Catalog No.:AA00AQ94

1481677-78-4 | Unc0642

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$45.00   $32.00
- +
5mg
98%
in stock  
$85.00   $60.00
- +
10mg
98%
in stock  
$169.00   $118.00
- +
50mg
98%
in stock  
$436.00   $305.00
- +
1000mg
98% by HPLC
in stock  
$7,126.00   $4,988.00
- +
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00AQ94
Chemical Name:
Unc0642
CAS Number:
1481677-78-4
Molecular Formula:
C29H44F2N6O2
Molecular Weight:
546.6955
MDL Number:
MFCD28044322
SMILES:
COc1cc2c(NC3CCN(CC3)C(C)C)nc(nc2cc1OCCCN1CCCC1)N1CCC(CC1)(F)F
Properties
Computed Properties
 
Complexity:
739  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
39  
Hydrogen Bond Acceptor Count:
10  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
10  
XLogP3:
5.7  

Upstream Synthesis Route

[1]JournalofMedicinalChemistry,2013,vol.56,#21,p.8931-8942

[1]JournalofMedicinalChemistry,2013,vol.56,#21,p.8931-8942

[1]JournalofMedicinalChemistry,2013,vol.56,#21,p.8931-8942

[1]JournalofMedicinalChemistry,2013,vol.56,#21,p.8931-8942

[1]JournalofMedicinalChemistry,2013,vol.56,#21,p.8931-8942

Downstream Synthesis Route

[1]JournalofMedicinalChemistry,2013,vol.56,p.8931-8942

Literature

Title: YM155 as an inhibitor of cancer stemness simultaneously inhibits autophosphorylation of epidermal growth factor receptor and G9a-mediated stemness in lung cancer cells.

Journal: PloS one 20170101

Title: Discovery of an in vivo chemical probe of the lysine methyltransferases G9a and GLP.

Journal: Journal of medicinal chemistry 20131114

Title: Job satisfaction in a chronic care facility.

Journal: Dimensions in health service 19760101

Title: Liu F, et al. Discovery of an in vivo chemical probe of the lysine methyltransferases G9a and GLP. J Med Chem. 2013 Nov 14;56(21):8931-8942.

Title: Wang L, et al. Targeting EHMT2 reverses EGFR-TKI resistance in NSCLC by epigenetically regulating the PTEN/AKT signaling pathway. Cell Death Dis. 2018 Jan 26;9(2):129

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SDS
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