Home Amines 148717-90-2
148717-90-2,MFCD15146903
Catalog No.:AA00ABJ0

148717-90-2 | Squalamine

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1mg
98%
1 week  
$765.00   $535.00
- +
5mg
98%
1 week  
$1,447.00   $1,013.00
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10mg
98%
1 week  
$2,273.00   $1,591.00
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50mg
98%
1 week  
$7,162.00   $5,013.00
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  • Technical Information
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  • Technical Information
  • Properties
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Technical Information
Catalog Number:
AA00ABJ0
Chemical Name:
Squalamine
CAS Number:
148717-90-2
Molecular Formula:
C34H65N3O5S
Molecular Weight:
627.9620
MDL Number:
MFCD15146903
SMILES:
NCCCCNCCCN[C@H]1CC[C@]2([C@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CC[C@H](C(C)C)OS(=O)(=O)O)C)C)O)C
Properties
Computed Properties
 
Complexity:
976  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
11  
Heavy Atom Count:
43  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
5  
Rotatable Bond Count:
16  
XLogP3:
4.3  

Literature

Title: Synthesis of new 3,20-bispolyaminosteroid squalamine analogues and evaluation of their antimicrobial activities.

Journal: Journal of medicinal chemistry 20111027

Title: Squalamine ointment for Staphylococcus aureus skin decolonization in a mouse model.

Journal: The Journal of antimicrobial chemotherapy 20110601

Title: In vitro activity of aminosterols against yeasts involved in blood stream infections.

Journal: Medical mycology 20110201

Title: Changes in mitochondrial surface charge mediate recruitment of signaling molecules during apoptosis.

Journal: American journal of physiology. Cell physiology 20110101

Title: Biophysical studies of the interaction of squalamine and other cationic amphiphilic molecules with bacterial and eukaryotic membranes: importance of the distribution coefficient in membrane selectivity.

Journal: Chemistry and physics of lipids 20100201

Title: Antimicrobial activities of 3-amino- and polyaminosterol analogues of squalamine and trodusquemine.

Journal: Journal of enzyme inhibition and medicinal chemistry 20081201

Title: New stereoselective titanium reductive amination synthesis of 3-amino and polyaminosterol derivatives possessing antimicrobial activities.

Journal: European journal of medicinal chemistry 20080301

Title: Squalamine: an appropriate strategy against the emergence of multidrug resistant gram-negative bacteria?

Journal: PloS one 20080101

Title: Identification of squalamine in the plasma membrane of white blood cells in the sea lamprey, Petromyzon marinus.

Journal: Journal of lipid research 20071201

Title: [Recent advances in the study of antifungal lead compounds with new chemical scaffolds].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20071101

Title: A bioconjugate approach toward squalamine mimics: Insight into the mechanism of biological action.

Journal: Bioconjugate chemistry 20060101

Title: Apparent receptor-mediated activation of Ca2+-dependent conductive Cl- transport by shark-derived polyaminosterols.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20051201

Title: Adjunctive therapy for men with high risk localized and locally advanced prostate cancer: targeting disseminated tumor cells.

Journal: The Journal of urology 20041201

Title: Synthesis of 7 alpha- and 7 beta-spermidinylcholesterol, squalamine analogues.

Journal: Bioorganic & medicinal chemistry letters 20040816

Title: Regression of retinopathy by squalamine in a mouse model.

Journal: Pediatric research 20040701

Title: Squalamine lactate reduces choroidal neovascularization in a laser-injury model in the rat.

Journal: Retina (Philadelphia, Pa.) 20031201

Title: Formal synthesis of squalamine from desmosterol.

Journal: Chemical & pharmaceutical bulletin 20031001

Title: Determination of degradation products of squalamine lactate using LC/MS.

Journal: Journal of pharmaceutical and biomedical analysis 20030424

Title: Effect of squalamine on iris neovascularization in monkeys.

Journal: Retina (Philadelphia, Pa.) 20021201

Title: Appetite suppression and weight reduction by a centrally active aminosterol.

Journal: Diabetes 20020701

Title: The synthesis of spermine analogs of the shark aminosterol squalamine.

Journal: Steroids 20020301

Title: Synthesis and antimicrobial activity of new 3 alpha-hydroxy-23,24-bisnorcholane polyamine carbamates.

Journal: Bioorganic & medicinal chemistry letters 20011203

Title: Partial correction of defective Cl(-) secretion in cystic fibrosis epithelial cells by an analog of squalamine.

Journal: American journal of physiology. Lung cellular and molecular physiology 20011101

Title: Déjà vu guides the way to new antimicrobial steroid.

Journal: Science (New York, N.Y.) 19930219

Title: Squalamine: an aminosterol antibiotic from the shark.

Journal: Proceedings of the National Academy of Sciences of the United States of America 19930215

Title: Zasloff M, et al. Squalamine as a broad-spectrum systemic antiviral agent with therapeutic potential. Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):15978-83.

Title: Hraiech S, et al. Antibacterial efficacy of inhaled squalamine in a rat model of chronic Pseudomonas aeruginosa pneumonia. J Antimicrob Chemother. 2012 Oct;67(10):2452-8.

Title: Djouhri-Bouktab L, et al. Squalamine ointment for Staphylococcus aureus skin decolonization in a mouse model. J Antimicrob Chemother. 2011 Jun;66(6):1306-10.

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