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149055-79-8,MFCD00903910
Catalog No.:AA00ATCP

149055-79-8 | N-tert-Butyl-3-(4-(2-methoxyphenyl)-piperazin-1-yl) -2-phenylpropanamide dihydrochloride

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10mg
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50mg
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00ATCP
Chemical Name:
N-tert-Butyl-3-(4-(2-methoxyphenyl)-piperazin-1-yl) -2-phenylpropanamide dihydrochloride
CAS Number:
149055-79-8
Molecular Formula:
C24H35Cl2N3O2
Molecular Weight:
468.4596
MDL Number:
MFCD00903910
SMILES:
COc1ccccc1N1CCN(CC1)CC(C(=O)NC(C)(C)C)c1ccccc1.Cl.Cl
Properties
Computed Properties
 
Complexity:
505  
Covalently-Bonded Unit Count:
3  
Heavy Atom Count:
31  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
7  
Undefined Atom Stereocenter Count:
1  

Literature

Title: Serotonin-induced brain glycogenolysis in rainbow trout (Oncorhynchus mykiss).

Journal: The Journal of experimental biology 20120901

Title: Cannabidiol, a non-psychotropic component of cannabis, attenuates vomiting and nausea-like behaviour via indirect agonism of 5-HT(1A) somatodendritic autoreceptors in the dorsal raphe nucleus.

Journal: British journal of pharmacology 20120401

Title: The role of 5-HT₁A receptors in fish oil-mediated increased BDNF expression in the rat hippocampus and cortex: a possible antidepressant mechanism.

Journal: Neuropharmacology 20120101

Title: Effect of selective serotonin reuptake inhibitors via 5-HT1A receptors on L-DOPA-induced rotational behavior in a hemiparkinsonian rat model.

Journal: Journal of pharmacological sciences 20120101

Title: Central PGE2 exhibits anxiolytic-like activity via EP1 and EP4 receptors in a manner dependent on serotonin 5-HT1A, dopamine D1 and GABAA receptors.

Journal: FEBS letters 20110721

Title: No association between serotonin 5-HT 1A receptors and spirituality among patients with major depressive disorders or healthy volunteers.

Journal: Molecular psychiatry 20110301

Title: Multiple neural oscillators and muscle feedback are required for the intestinal fed state motor program.

Journal: PloS one 20110101

Title: Role of cortical and striatal 5-HT1A receptors in alleviating antipsychotic-induced extrapyramidal disorders.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20100816

Title: 5-HT(1A), SST(1), and SST(2) receptors mediate inhibitory postsynaptic potentials in the submucous plexus of the guinea pig ileum.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20100301

Title: Effects of tandospirone, a 5-HT1A agonistic anxiolytic agent, on haloperidol-induced catalepsy and forebrain Fos expression in mice.

Journal: Journal of pharmacological sciences 20090401

Title: Interplay between glutamate and serotonin within the dorsal periaqueductal gray modulates anxiety-related behavior of rats exposed to the elevated plus-maze.

Journal: Behavioural brain research 20081212

Title: Anticataleptic 8-OH-DPAT preferentially counteracts with haloperidol-induced Fos expression in the dorsolateral striatum and the core region of the nucleus accumbens.

Journal: Neuropharmacology 20081001

Title: Evaluation of the antibradykinetic actions of 5-HT1A agonists using the mouse pole test.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20080701

Title: Attenuating effects of prior oestradiol benzoate priming on 5-HT-mediated lordosis behavior in rats are dose-dependent.

Journal: Acta physiologica Hungarica 20070901

Title: Inhibition of opioid release in the rat spinal cord by serotonin 5-HT(1A) receptors.

Journal: Brain research 20070716

Title: Repeated treatment with cannabidiol but not Delta9-tetrahydrocannabinol has a neuroprotective effect without the development of tolerance.

Journal: Neuropharmacology 20070301

Title: The 5HT(7) receptor subtype is involved in the regulation of female sexual behaviour in the rat.

Journal: Pharmacology, biochemistry, and behavior 20070101

Title: Characteristics of binding of [3H]WAY100635 to rat hippocampal membranes.

Journal: Neurochemical research 20060901

Title: Neuromodulatory role of 5-hydroxytryptamine type 1A receptors on the excitability of Renshaw cells in the rat spinal cord.

Journal: Neuroreport 20060821

Title: Effects of sarizotan on the corticostriatal glutamate pathways.

Journal: Synapse (New York, N.Y.) 20051201

Title: 5-Hydroxytryptamine induced excitation and inhibition in the subthalamic nucleus: action at 5-HT(2C), 5-HT(4) and 5-HT(1A) receptors.

Journal: Neuropharmacology 20051201

Title: Perospirone, a novel antipsychotic drug, inhibits marble-burying behavior via 5-HT1A receptor in mice: implications for obsessive-compulsive disorder.

Journal: Journal of pharmacological sciences 20051001

Title: Serotonergic/glutamatergic interactions: potentiation of phencyclidine-induced stimulus control by citalopram.

Journal: Pharmacology, biochemistry, and behavior 20050701

Title: Cannabidiol prevents cerebral infarction via a serotonergic 5-hydroxytryptamine1A receptor-dependent mechanism.

Journal: Stroke 20050501

Title: Involvement of spinal serotonin receptors in the regulation of intraspinal acetylcholine release.

Journal: European journal of pharmacology 20050221

Title: Propranolol modulates trigeminovascular responses in thalamic ventroposteromedial nucleus: a role in migraine?

Journal: Brain : a journal of neurology 20050101

Title: Differential cAMP levels and serotonin effects in blood peripheral mononuclear cells and lymphocytes from major depression patients.

Journal: International immunopharmacology 20040801

Title: 5-HT7 receptor subtype as a mediator of the serotonergic regulation of luteinizing hormone release in the zona incerta.

Journal: European journal of pharmacology 20040426

Title: 8-OH-DPAT acts on both 5-HT1A and 5-HT7 receptors to induce hypothermia in rodents.

Journal: European journal of pharmacology 20040308

Title: Endogenous 5-HT inhibits firing activity of hippocampal CA1 pyramidal neurons during conditioned fear stress-induced freezing behavior through stimulating 5-HT1A receptors.

Journal: Hippocampus 20040101

Title: 8-OHDPAT-induced disruption of prepulse inhibition in rats is attenuated by prolonged corticosterone treatment.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20030701

Title: Role of serotonin1A receptors on the modulation of rat spinal mono-synaptic reflexes in vitro.

Journal: Neuroscience letters 20021206

Title: Region-dependent effects of flibanserin and buspirone on adenylyl cyclase activity in the human brain.

Journal: The international journal of neuropsychopharmacology 20020601

Title: Supersensitivity of 5-HT1A autoreceptors and alpha2-adrenoceptors regulating monoamine synthesis in the brain of morphine-dependent rats.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20020301

Title: Mechanism of action of flibanserin in the learned helplessness paradigm in rats.

Journal: European journal of pharmacology 20011214

Title: Effects of selective 5-HT1A receptor antagonists on regional serotonin synthesis in the rat brain: an autoradiographic study with alpha-[14C]methyl-L-tryptophan.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20010601

Title: 5-HT1A receptor activation and antidepressant-like effects: F 13714 has high efficacy and marked antidepressant potential.

Journal: European journal of pharmacology 20010525

Title: 1,2,5-Thiadiazole derivatives are potent and selective ligands at human 5-HT1A receptors.

Journal: Bioorganic & medicinal chemistry letters 20010423

Title: Ligand induced conformational states of the 5-HT(1A) receptor.

Journal: European journal of pharmacology 20010323

Title: Further characterization of 5-HT1A receptors in the goldfish retina: role of cyclic AMP in the regulation of the in vitro outgrowth of retinal explants.

Journal: Neurochemical research 20010301

Title: The major role of peripheral release of histamine and 5-hydroxytryptamine in formalin-induced nociception.

Journal: Neuroscience 20010101

Title: (+)-WAY 100135, a partial agonist, at native and recombinant 5-HT1B/1D receptors.

Journal: British journal of pharmacology 19970601

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Tags:149055-79-8 Molecular Formula|149055-79-8 MDL|149055-79-8 SMILES|149055-79-8 N-tert-Butyl-3-(4-(2-methoxyphenyl)-piperazin-1-yl) -2-phenylpropanamide dihydrochloride