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Title: Inhibition of cytosolic phospholipase A(2) alpha protects against focal ischemic brain damage in mice.
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Title: Cysteinyl leukotrienes mediate the response of submucosal ganglia from rat colon to bradykinin.
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Title: Stimulation of Ca2+-sensing receptor inhibits the basolateral 50-pS K channels in the thick ascending limb of rat kidney.
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Title: Arachidonyl trifluoromethyl ketone ameliorates experimental autoimmune encephalomyelitis via blocking peroxynitrite formation in mouse spinal cord white matter.
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Title: Cytosolic phospholipase A2 as a molecular target for the radiosensitization of ovarian cancer.
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Title: Stimulation of A(₂a) adenosine receptor abolishes the inhibitory effect of arachidonic acid on the basolateral 50-pS K channel in the thick ascending limb.
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Title: Structure-activity relationship studies on 1-(5-carboxyindol-1-yl)-propan-2-one inhibitors of human cytosolic phospholipase A2α: variation of the activated ketone moiety.
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Title: Delayed production of arachidonic acid contributes to the delay of proteinase-activated receptor-1 (PAR1)-triggered prostaglandin E2 release in rat gastric epithelial RGM1 cells.
Journal: Journal of cellular biochemistry 20110301
Title: COX-2 inhibition and inhibition of cytosolic phospholipase A2 increase CD36 expression and foam cell formation in THP-1 cells.
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Title: Peroxisome proliferation activation receptor alpha modulation of Ca2+-regulated exocytosis via arachidonic acid in guinea-pig antral mucous cells.
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Title: TLR4-dependent induction of vascular adhesion molecule-1 in rheumatoid arthritis synovial fibroblasts: Roles of cytosolic phospholipase A(2)alpha/cyclooxygenase-2.
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Title: Evidence for de novo synthesis of lysophosphatidic acid in the spinal cord through phospholipase A2 and autotaxin in nerve injury-induced neuropathic pain.
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Title: Nanomolar vitamin E alpha-tocotrienol inhibits glutamate-induced activation of phospholipase A2 and causes neuroprotection.
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Title: 1-Indol-1-yl-propan-2-ones and related heterocyclic compounds as dual inhibitors of cytosolic phospholipase A(2)alpha and fatty acid amide hydrolase.
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Title: Cytosolic phospholipase A2alpha mediates Pseudomonas aeruginosa LPS-induced airway constriction of CFTR -/- mice.
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Title: Mechanism underlying endothelium-dependent relaxation by 2-methylthio-ADP in monkey cerebral artery.
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Title: Synthesis and in vitro evaluation of N-substituted maleimide derivatives as selective monoglyceride lipase inhibitors.
Journal: Journal of medicinal chemistry 20091210
Title: Group IVA phospholipase A(2) activity may mediate prostaglandin F(2alpha)-induced luteal regression in pseudopregnant rats.
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Title: Bis(dialkylaminethiocarbonyl)disulfides as potent and selective monoglyceride lipase inhibitors.
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Title: Arachidonic acid: a key molecule for astrocyte survival to peroxynitrite.
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Title: Arachidonyl trifluoromethyl ketone is neuroprotective after spinal cord injury.
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Title: Characterization of the pattern of the nongenomic signaling pathway through which TCDD-induces early inflammatory responses in U937 human macrophages.
Journal: Chemosphere 20090301
Title: Cytosolic phospholipase A2: targeting cancer through the tumor vasculature.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20090301
Title: Significance of the nongenomic, inflammatory pathway in mediating the toxic action of TCDD to induce rapid and long-term cellular responses in 3T3-L1 adipocytes.
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Title: Initial and extended inflammatory messages of the nongenomic signaling pathway of the TCDD-activated Ah receptor in U937 macrophages.
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Title: Ca2+-independent PLA2 controls endothelial store-operated Ca2+ entry and vascular tone in intact aorta.
Journal: American journal of physiology. Heart and circulatory physiology 20081201
Title: Simultaneous stimulation of spinal NK1 and NMDA receptors produces LPC which undergoes ATX-mediated conversion to LPA, an initiator of neuropathic pain.
Journal: Journal of neurochemistry 20081201
Title: Inhibition of cyclooxygenases 1 and 2 by the phospholipase-blocker, arachidonyl trifluoromethyl ketone.
Journal: British journal of pharmacology 20081101
Title: Phospholipase A2 reduction ameliorates cognitive deficits in a mouse model of Alzheimer's disease.
Journal: Nature neuroscience 20081101
Title: Identification and functional characterization of adipose-specific phospholipase A2 (AdPLA).
Journal: The Journal of biological chemistry 20080912
Title: [Suppression of cell proliferation by inhibitors to redox signaling in human lens epithelial cells].
Journal: [Zhonghua yan ke za zhi] Chinese journal of ophthalmology 20080701
Title: Tumour necrosis factor alpha upregulates platelet CD40L in patients with heart failure.
Journal: Cardiovascular research 20080601
Title: Activation of cytosolic phospholipase A2 and fatty acid transacylase is essential but not sufficient for thrombin-induced smooth muscle cell proliferation.
Journal: American journal of physiology. Cell physiology 20080601
Title: Cytochrome P-450 metabolites of 2-arachidonoylglycerol play a role in Ca2+-induced relaxation of rat mesenteric arteries.
Journal: American journal of physiology. Heart and circulatory physiology 20080501
Title: Cytosolic phospholipase A2 and arachidonic acid metabolites modulate ventilator-induced permeability increases in isolated mouse lungs.
Journal: Journal of applied physiology (Bethesda, Md. : 1985) 20080201
Title: Evidence that PAR2-triggered prostaglandin E2 (PGE2) formation involves the ERK-cytosolic phospholipase A2-COX-1-microsomal PGE synthase-1 cascade in human lung epithelial cells.
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Title: Arachidonic acid as a retrograde signal controlling growth and dynamics of retinotectal arbors.
Journal: Developmental neurobiology 20080101
Title: STAT5 mediates PAF-induced NADPH oxidase NOX5-S expression in Barrett's esophageal adenocarcinoma cells.
Journal: American journal of physiology. Gastrointestinal and liver physiology 20080101
Title: Involvement of cPLA2 inhibition in dexamethasone-induced thymocyte apoptosis.
Journal: International journal of immunopathology and pharmacology 20080101
Title: Role of phospholipase A2 (group I secreted) in the genesis of basal tone in the internal anal sphincter smooth muscle.
Journal: American journal of physiology. Gastrointestinal and liver physiology 20071101
Title: Arachidonic acid signaling is involved in the mechanism of imidazoline-induced KATP channel-independent stimulation of insulin secretion.
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Title: A novel role of group VIB calcium-independent phospholipase A2 (iPLA2gamma) in the inducible expression of group IIA secretory PLA2 in rat fibroblastic cells.
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Title: Apoptosis is mediated by cytosolic phospholipase A2 during simulated ischaemia/reperfusion-induced injury in neonatal cardiac myocytes.
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Title: Regulation of luteal prostaglandin F(2 alpha) production and its relevance to cell death: an in vitro study using rat dispersed luteal cells.
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Title: 1-(5-Carboxy- and 5-carbamoylindol-1-yl)propan-2-ones as inhibitors of human cytosolic phospholipase A2alpha: bioisosteric replacement of the carboxylic acid and carboxamide moiety.
Journal: Bioorganic & medicinal chemistry 20070415
Title: Effects of arachidonate metabolism inhibitors on basal and human chorionic gonadotropin-stimulated progesterone secretion by rat corpus luteum cells in vitro.
Journal: Prostaglandins & other lipid mediators 20070201
Title: Lysophosphatidylcholine induces inflammatory activation of human coronary artery smooth muscle cells.
Journal: Molecular and cellular biochemistry 20070101
Title: Cytosolic PLA2 in zymogen granule fusion and amylase release: inhibition of GTP-induced fusion by arachidonyl trifluoromethyl ketone points to cPLA2 in G-protein-mediated secretory vesicle fusion.
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Title: The role of arachidonic acid and its metabolites in insulin secretion from human islets of langerhans.
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Title: Amyloid beta enhances cytosolic phospholipase A2 level and arachidonic acid release via nitric oxide in APP-transfected PC12 cells.
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Title: Phospholipase A2 activation regulates cytotoxicity of methylmercury in vascular endothelial cells.
Journal: International journal of toxicology 20070101
Title: Cytosolic phospholipase A alpha modulates NMDA neurotoxicity in mouse hippocampal cultures.
Journal: The European journal of neuroscience 20061201
Title: Effects of pyrrophenone, an inhibitor of group IVA phospholipase A2, on eicosanoid and PAF biosynthesis in human neutrophils.
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Title: Pro-atherogenic effect of interleukin-4 in endothelial cells: modulation of oxidative stress, nitric oxide and monocyte chemoattractant protein-1 expression.
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Title: Cytosolic phospholipase A2 inhibition attenuates ischemia-reperfusion injury in an isolated rat lung model.
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Title: Targeting cytosolic phospholipase A2 by arachidonyl trifluoromethyl ketone prevents chronic inflammation in mice.
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Title: Lysophosphatidic acid is constitutively produced by human peritoneal mesothelial cells and enhances adhesion, migration, and invasion of ovarian cancer cells.
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Title: Vasorelaxant effects of oleamide in rat small mesenteric artery indicate action at a novel cannabinoid receptor.
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Title: Homeodomain-interacting protein kinase-2 restrains cytosolic phospholipase A2-dependent prostaglandin E2 generation in human colorectal cancer cells.
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Title: The cellular mechanisms by which adenosine evokes release of nitric oxide from rat aortic endothelium.
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Title: Enhancement of Ca2+-regulated exocytosis by indomethacin in guinea-pig antral mucous cells: arachidonic acid accumulation.
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Title: A novel role for calcium-independent phospholipase A in alpha-amino-3-hydroxy-5-methylisoxazole-propionate receptor regulation during long-term potentiation.
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Title: Activation of BK channels in GH3 cells by a c-PLA2-dependent G-protein signaling pathway.
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Title: Clara cell secretory protein and phospholipase A2 activity modulate acute ventilator-induced lung injury in mice.
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Title: Oxidant-mediated activation of cytosolic phospholipase a(2) in pulmonary endothelium: role of protein kinase C alpha and a pertussis toxin-sensitive protein.
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Title: Amyloid beta(1-42) and its beta(25-35) fragment induce activation and membrane translocation of cytosolic phospholipase A2 in bovine retina capillary pericytes.
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Title: Role of an aprotinin-sensitive protease in protein kinase Calpha-mediated activation of cytosolic phospholipase A2 by calcium ionophore (A23187) in pulmonary endothelium.
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Title: Hypoxia activates matrix metalloproteinase expression and the VEGF system in monkey choroid-retinal endothelial cells: Involvement of cytosolic phospholipase A2 activity.
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Title: Mercury- and copper-induced lysosomal membrane destabilisation depends on [Ca2+]i dependent phospholipase A2 activation.
Journal: Aquatic toxicology (Amsterdam, Netherlands) 20040210
Title: Cytosolic phospholipase A2 plays a key role in the pathogenesis of multiple sclerosis-like disease.
Journal: Neuron 20040205
Title: Cytosolic and mitochondrial ROS in staurosporine-induced retinal cell apoptosis.
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Title: Prostacyclin production in rat aortic smooth muscle cells: role of protein kinase C, phospholipase D and cyclooxygenase-2 expression.
Journal: Cardiovascular research 20031101
Title: Phospholipase A2 plays an important role in myelin breakdown and phagocytosis during Wallerian degeneration.
Journal: Molecular and cellular neurosciences 20031101
Title: 17Beta-eEstradiol stimulates arachidonate release from human amnion-like WISH cells through a rapid mechanism involving a membrane receptor.
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Title: A potent inhibitor of cytosolic phospholipase A2, arachidonyl trifluoromethyl ketone, attenuates LPS-induced lung injury in mice.
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Title: Resveratrol activates adenylyl-cyclase in human breast cancer cells: a novel, estrogen receptor-independent cytostatic mechanism.
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Title: Methylmercury-induced reactive oxygen species formation in neonatal cerebral astrocytic cultures is attenuated by antioxidants.
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Title: Phospholipase A2 modulates respiratory burst developed by neutrophils in patients with rheumatoid arthritis.
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Title: Endothelial NADPH oxidase: mechanism of activation by low-density lipoprotein.
Journal: Endothelium : journal of endothelial cell research 20030101
Title: Peroxynitrite stimulates the activity of cytosolic phospholipase A2 in U937 cells: the extent of arachidonic acid formation regulates the balance between cell survival or death.
Journal: Cell death and differentiation 20021201
Title: Essential role of Ca2+ -dependent phospholipase A2 in estradiol-induced lysosome activation.
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Title: Role of cytoplasmic phospholipase A2 in endothelium-derived hyperpolarizing factor dilations of rat middle cerebral arteries.
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Title: Involvement of oxidative stress in bee venom-induced inhibition of Na+/glucose cotransporter in renal proximal tubule cells.
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Title: Dopamine D(2) receptor-induced COX-2-mediated production of prostaglandin E(2) in D(2)-transfected Chinese hamster ovary cells without simultaneous administration of a Ca(2+)-mobilizing agent.
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Title: Determination of the cell lytic properties of amphiphilic inhibitors of the cytosolic phospholipase A2 against human platelets by measuring the liberation of serotonin with high-performance liquid chromatography and fluorescence detection.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20020325
Title: Design and synthesis of a novel and potent series of inhibitors of cytosolic phospholipase A(2) based on a 1,3-disubstituted propan-2-one skeleton.
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Title: Arachidonate metabolism and the signaling pathway of induction of apoptosis by oxidized LDL/oxysterol.
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Title: Differential role of cytosolic phospholipase A2 in the invasion of brain microvascular endothelial cells by Escherichia coli and Listeria monocytogenes.
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Title: Calcium-independent phospholipase A(2) is required for human monocyte chemotaxis to monocyte chemoattractant protein 1.
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Title: Platelet-derived growth factor stimulates phospholipase C-gamma 1, extracellular signal-regulated kinase, and arachidonic acid release in rat myometrial cells: contribution to cyclic 3',5'-adenosine monophosphate production and effect on cell proliferation.
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Title: Effects of phospholipase A(2) activating peptides upon GTP-binding protein-evoked adrenocorticotrophin secretion.
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Title: Role of prostaglandins in the suppression of apoptosis in hen granulosa cells by transforming growth factor alpha.
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