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149649-22-9,MFCD00920172
Catalog No.:AA001LTK

149649-22-9 | 2-Naphthalenecarboxamide, N-[(1-butyl-2-pyrrolidinyl)methyl]-4-cyano-1-methoxy-

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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA001LTK
Chemical Name:
2-Naphthalenecarboxamide, N-[(1-butyl-2-pyrrolidinyl)methyl]-4-cyano-1-methoxy-
CAS Number:
149649-22-9
Molecular Formula:
C22H27N3O2
Molecular Weight:
365.4687
MDL Number:
MFCD00920172
SMILES:
CCCCN1CCCC1CNC(=O)c1cc(C#N)c2c(c1OC)cccc2
Properties
Computed Properties
 
Complexity:
543  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
27  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
7  
Undefined Atom Stereocenter Count:
1  
XLogP3:
4  

Literature

Title: Reduced expression of haloperidol conditioned catalepsy in rats by the dopamine D3 receptor antagonists nafadotride and NGB 2904.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20121001

Title: Pharmacological modulation of amphetamine-induced dyskinesia in transplanted hemi-parkinsonian rats.

Journal: Neuropharmacology 20121001

Title: The dopamine D2 receptor regulates Akt and GSK-3 via Dvl-3.

Journal: The international journal of neuropsychopharmacology 20120801

Title: Comparison of nafadotride, CNQX, and haloperidol on acquisition versus expression of amphetamine-conditioned place preference in rats.

Journal: Behavioural pharmacology 20120201

Title: Modulation of high impulsivity and attentional performance in rats by selective direct and indirect dopaminergic and noradrenergic receptor agonists.

Journal: Psychopharmacology 20120101

Title: D(2)-like dopamine receptors differentially regulate unitary IPSCs depending on presynaptic GABAergic neuron subtypes in rat nucleus accumbens shell.

Journal: Journal of neurophysiology 20120101

Title: The neuroprotective disease-modifying potential of psychotropics in Parkinson's disease.

Journal: Parkinson's disease 20120101

Title: Inverse agonism and its therapeutic significance.

Journal: Indian journal of pharmacology 20110101

Title: Beyond cAMP: The Regulation of Akt and GSK3 by Dopamine Receptors.

Journal: Frontiers in molecular neuroscience 20110101

Title: Dopamine D3 receptor knock-out mice display deficits in locomotor sensitization after chronic morphine administration.

Journal: Neuroscience letters 20101126

Title: Participation of D 1-4 dopamine receptors in the pro-cognitive effects of angiotensin IV and des-Phe 6 angiotensin IV.

Journal: Neuroscience and biobehavioral reviews 20100301

Title: Dissociable control of impulsivity in rats by dopamine d2/3 receptors in the core and shell subregions of the nucleus accumbens.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20100101

Title: Curcumin modulates dopaminergic receptor, CREB and phospholipase C gene expression in the cerebral cortex and cerebellum of streptozotocin induced diabetic rats.

Journal: Journal of biomedical science 20100101

Title: Dopamine-oxytocin interactions in penile erection.

Journal: The European journal of neuroscience 20091203

Title: Sex differences in nicotine sensitization and conditioned hyperactivity in adolescent rats neonatally treated with quinpirole: role of D2 and D3 receptor subtypes.

Journal: Behavioral neuroscience 20091201

Title: Acute neurobehavioral effects of toluene: involvement of dopamine and NMDA receptors.

Journal: Toxicology 20091109

Title: Effects of pramipexole on the duration of immobility during the forced swim test in normal and ACTH-treated rats.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20090701

Title: Attenuation of the effects of d-amphetamine on interval timing behavior by central 5-hydroxytryptamine depletion.

Journal: Psychopharmacology 20090401

Title: Dopamine D2/D3 receptor agonist quinpirole impairs spatial reversal learning in rats: investigation of D3 receptor involvement in persistent behavior.

Journal: Psychopharmacology 20090301

Title: Dopaminergic modulation of risk-based decision making.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20090201

Title: The D2/D3 agonist PD128907 (R-(+)-trans-3,4a,10b-tetrahydro-4-propyl-2H,5H-[1]benzopyrano[4,3-b]-1,4-oxazin-9-ol) inhibits stimulated pyloric relaxation and spontaneous gastric emptying.

Journal: Digestive diseases and sciences 20090101

Title: Effect of D(3) dopamine receptors blockade on the cognitive effects of angiotensin IV in rats.

Journal: Neuropeptides 20080601

Title: Juvenile methylphenidate modulates reward-related behaviors and cerebral blood flow by decreasing cortical D3 receptors.

Journal: The European journal of neuroscience 20080601

Title: Selegilin exerts antidepressant-like effects during the forced swim test in adrenocorticotropic hormone-treated rats.

Journal: Journal of pharmacological sciences 20080401

Title: Microinjection of the preferential dopamine receptor D3 agonist 7-hydroxy-N,N-di-n-propylaminotetralin hydrobromide into the hypothalamic medial preoptic area induced ejaculation in anesthetized rats.

Journal: Neuroscience 20071109

Title: Effect of quinpirole on timing behaviour in the free-operant psychophysical procedure: evidence for the involvement of D2 dopamine receptors.

Journal: Psychopharmacology 20070801

Title: Mediating effect of dopamine D3 receptors on Jak2 and GABAAalpha1 expression in mouse brains induced by cocaine.

Journal: Chinese medical journal 20070520

Title: Behavioral and neuropharmacological characterization of nicotine as a conditional stimulus.

Journal: European journal of pharmacology 20070430

Title: Ejaculation induced by i.c.v. injection of the preferential dopamine D(3) receptor agonist 7-hydroxy-2-(di-N-propylamino)tetralin in anesthetized rats.

Journal: Neuroscience 20070316

Title: Activation of D2-like receptors induces sympathetic climactic-like responses in male and female anaesthetised rats.

Journal: British journal of pharmacology 20060601

Title: Dopamine receptors oppositely regulate cocaine-induced transcription factor CREB activation.

Journal: Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20060601

Title: Involvement of adenosine A2A and dopamine receptors in the locomotor and sensitizing effects of cocaine.

Journal: Brain research 20060310

Title: Validation of the l-dopa-induced dyskinesia in the 6-OHDA model and evaluation of the effects of selective dopamine receptor agonists and antagonists.

Journal: Brain research bulletin 20051215

Title: Dopamine agonist-induced yawning in rats: a dopamine D3 receptor-mediated behavior.

Journal: The Journal of pharmacology and experimental therapeutics 20050701

Title: Dopamine D3 modulation of locomotor activity and sleep in the nucleus accumbens and in lobules 9 and 10 of the cerebellum in the rat.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20050601

Title: Biological effects of pramipexole on dopaminergic neuron-associated genes: relevance to neuroprotection.

Journal: Neuroscience letters 20050329

Title: Prenatal ethanol preferentially enhances reactivity of the dopamine D1 but not D2 or D3 receptors in offspring.

Journal: Neurotoxicology and teratology 20050101

Title: Central effects of nafadotride, a dopamine D3 receptor antagonist, in rats. Comparison with haloperidol and clozapine.

Journal: Pharmacological reports : PR 20050101

Title: Conversion of the modulatory actions of dopamine on spinal reflexes from depression to facilitation in D3 receptor knock-out mice.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20041215

Title: Effects of dopamine D3 receptor antagonists on spontaneous and agonist-reduced motor activity in NMRI mice and Wistar rats: comparative study with nafadotride, U 99194A and SB 277011.

Journal: Behavioural pharmacology 20040701

Title: Selective optimization of side activities: another way for drug discovery.

Journal: Journal of medicinal chemistry 20040311

Title: Modulation of the locomotor activating effects of the noncompetitive NMDA receptor antagonist MK801 by dopamine D2/3 receptor agonists in mice.

Journal: Pharmacology, biochemistry, and behavior 20040201

Title: Modulation of the discriminative stimulus effects of mu opioid agonists in rats: I. Effects of dopamine D2/3 antagonists.

Journal: Behavioural pharmacology 20040201

Title: Molecular modeling of the three-dimensional structure of dopamine 3 (D3) subtype receptor: discovery of novel and potent D3 ligands through a hybrid pharmacophore- and structure-based database searching approach.

Journal: Journal of medicinal chemistry 20031009

Title: The dopamine D3 receptor mediates locomotor hyperactivity induced by NMDA receptor blockade.

Journal: Neuropharmacology 20030801

Title: Attenuation of levodopa-induced dyskinesia by normalizing dopamine D3 receptor function.

Journal: Nature medicine 20030601

Title: The modulatory actions of dopamine D2/3 agonists and antagonists on the locomotor-activating effects of morphine and caffeine in mice.

Journal: Pharmacology, biochemistry, and behavior 20030501

Title: Respective roles of dopamine D2 and D3 receptors in food-seeking behaviour in rats.

Journal: Psychopharmacology 20030201

Title: Dopamine D3 receptor ligands show place conditioning effect but do not influence cocaine-induced place preference.

Journal: Neuroreport 20030120

Title: Behavioral response profiles following drug challenge with dopamine receptor subtype agonists and antagonists in developing rat.

Journal: Neurotoxicology and teratology 20030101

Title: Nafadotride administration increases D1 and D1/D2 dopamine receptor mediated behaviors.

Journal: Behavioural pharmacology 20021201

Title: Blockade of sensitisation-induced facilitation of appetitive conditioning by post-session intra-amygdala nafadotride.

Journal: Behavioural brain research 20020821

Title: Isolation rearing-induced facilitation of Pavlovian learning: abolition by postsession intra-amygdala nafadotride.

Journal: Physiology & behavior 20020801

Title: Acute and chronic effects of methamphetamine on tele-methylhistamine levels in mouse brain: selective involvement of the D(2) and not D(3) receptor.

Journal: The Journal of pharmacology and experimental therapeutics 20020201

Title: Role of dopamine D3 receptors in controlling the expression of cocaine sensitization in rats.

Journal: Polish journal of pharmacology 20020101

Title: Is dopamine implicated in the antidepressant-like effects of selective serotonin reuptake inhibitors in the mouse forced swimming test?

Journal: Psychopharmacology 20011201

Title: Enduring resistance to extinction of cocaine-seeking behavior induced by drug-related cues.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20010901

Title: Common discriminative stimulus properties in rats of muscarinic antagonists, clozapine and the D3 preferring antagonist PNU-99194a: an analysis of possible mechanisms.

Journal: Behavioural pharmacology 20010901

Title: Identification of the dopamine autoreceptor in the guinea-pig retina as D(2) receptor using novel subtype-selective antagonists.

Journal: British journal of pharmacology 20010801

Title: Influence of social isolation and 6-OHDA lesion on the effects of quinelorane.

Journal: Pharmacology, biochemistry, and behavior 20010101

Title: Repeated imipramine treatment enhances the 7-OH-DPAT-induced hyperactivity in rats: the role of dopamine D2 and D3 receptors.

Journal: Polish journal of pharmacology 20010101

Title: Locomotor hypoactivity and motor disturbances--behavioral effects induced by intracerebellar microinjections of dopaminergic DA-D2/D3 receptor agonists.

Journal: Polish journal of pharmacology 20010101

Title: Discriminative stimulus properties of the dopamine D3 receptor agonists, PD128,907 and 7-OH-DPAT: a comparative characterization with novel ligands at D3 versus D2 receptors.

Journal: Neuropharmacology 20000214

Title: Role of dopamine D3 receptors in thermoregulation: a reappraisal.

Journal: Neuroreport 20000117

Title: Nonconserved residues in the second transmembrane-spanning domain of the D(4) dopamine receptor are molecular determinants of D(4)-selective pharmacology.

Journal: Molecular pharmacology 20000101

Title: Selective inhibition of cocaine-seeking behaviour by a partial dopamine D3 receptor agonist.

Journal: Nature 19990722

Title: The anticataleptic effect of 7-OH-DPAT: are dopamine D3 receptors involved?

Journal: Journal of neural transmission (Vienna, Austria : 1996) 19990101

Title: Agonist and antagonist actions of antipsychotic agents at 5-HT1A receptors: a [35S]GTPgammaS binding study.

Journal: European journal of pharmacology 19980821

Title: Coexpression of dopamine D1 and D3 receptors in islands of Calleja and shell of nucleus accumbens of the rat: opposite and synergistic functional interactions.

Journal: The European journal of neuroscience 19980501

Title: Opposite effects of dopamine D2 and D3 receptors on learning and memory in the rat.

Journal: European journal of pharmacology 19971008

Title: Nafadotride, a potent preferential dopamine D3 receptor antagonist, activates locomotion in rodents.

Journal: The Journal of pharmacology and experimental therapeutics 19951201

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Tags:149649-22-9 Molecular Formula|149649-22-9 MDL|149649-22-9 SMILES|149649-22-9 2-Naphthalenecarboxamide, N-[(1-butyl-2-pyrrolidinyl)methyl]-4-cyano-1-methoxy-