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149676-40-4,MFCD01685696
Catalog No.:AA00AOXR

149676-40-4 | 1-ETHYL-6-FLUORO-7-(4-METHYLPIPERAZIN-1-YL)-4-OXO-QUINOLINE-3-CARBOXYLIC ACID

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1g
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$24.00   $17.00
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5g
98%
in stock  
$43.00   $30.00
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10g
≥98%
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$53.00   $37.00
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25g
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00AOXR
Chemical Name:
1-ETHYL-6-FLUORO-7-(4-METHYLPIPERAZIN-1-YL)-4-OXO-QUINOLINE-3-CARBOXYLIC ACID
CAS Number:
149676-40-4
Molecular Formula:
C18H28FN3O8S
Molecular Weight:
465.4936
MDL Number:
MFCD01685696
SMILES:
CS(=O)(=O)O.CCn1cc(C(=O)O)c(=O)c2c1cc(N1CCN(CC1)C)c(c2)F.O.O
Properties
Properties
 
BP:
529.1°C at 760 mmHg  
Form:
Solid  
MP:
271°C  
Solubility:
H2O: soluble50mg/mL  
Stability:
Light Sensitive  
Storage:
Inert atmosphere;2-8℃;  

Computed Properties
 
Complexity:
638  
Covalently-Bonded Unit Count:
4  
Heavy Atom Count:
31  
Hydrogen Bond Acceptor Count:
12  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
3  

Downstream Synthesis Route

[1]Locationinpatent:experimentalpartVasiliev;Golovnev[JournalofStructuralChemistry,2010,vol.51,#1,p.177-180]

Literature

Title: Superparamagnetic surface molecularly imprinted nanoparticles for water-soluble pefloxacin mesylate prepared via surface initiated atom transfer radical polymerization and its application in egg sample analysis.

Journal: Journal of chromatography. A 20120713

Title: Effects of systemic ornidazole, systemic and local compound ornidazole and pefloxacin mesylate on experimental periodontitis in rats.

Journal: Medical science monitor : international medical journal of experimental and clinical research 20120101

Title: Oral toxicity of pefloxacin, norfloxacin, ofloxacin and ciprofloxacin: comparison of biomechanical and histopathological effects on Achilles tendon in rats.

Journal: The Journal of toxicological sciences 20110601

Title: Third generation fluoroquinolones antibacterial drug based mixed-ligand Cu(II) complexes: structure, antibacterial activity, superoxide dismutase activity and DNA-interaction approach.

Journal: Journal of enzyme inhibition and medicinal chemistry 20110401

Title: Effects of substituents on the NMR features of basic bicyclic ring systems of fluoroquinolone antibiotics and the relationships between NMR chemical shifts, molecular descriptors and drug-likeness parameters.

Journal: Acta pharmaceutica (Zagreb, Croatia) 20100901

Title: Near-infrared spectroscopy quantitative determination of pefloxacin mesylate concentration in pharmaceuticals by using partial least squares and principal component regression multivariate calibration.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20100501

Title: Selective sample pretreatment by molecularly imprinted polymer monolith for the analysis of fluoroquinolones from milk samples.

Journal: Journal of chromatography. A 20100402

Title: Effect of levofloxacin and pefloxacin on humoral immune response elicited by bovine serum albumin docked in gelatin microparticles and nanoparticles.

Journal: Die Pharmazie 20100401

Title: Modification of innervation pattern by fluoroquinolone treatment in the rat salivary glands.

Journal: Anatomical record (Hoboken, N.J. : 2007) 20100201

Title: Pharmacokinetics of pefloxacin mesylate in human urine using capillary electrophoresis electrochemiluminescence detection.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20090815

Title: Investigation on enhanced chemiluminescence reaction systems with bis(hydrogenperiodato) argentate(III) complex anion for fluoroquinolones synthetic antibiotics.

Journal: Talanta 20090715

Title: In vitro selection of allosteric ribozymes.

Journal: Methods in molecular biology (Clifton, N.J.) 20090101

Title: [Clinical and laboratory investigation of pefloxacin used prophylactically in operations on the liver].

Journal: Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] 20090101

Title: Schnitzler's syndrome: increased levels of bone formation and angiogenesis factors are reduced after successful pefloxacin treatment.

Journal: Clinical lymphoma & myeloma 20081201

Title: Multicomponent kinetic spectrophotometric determination of pefloxacin and norfloxacin in pharmaceutical preparations and human plasma samples with the aid of chemometrics.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20081001

Title: Studies on the crystal forms of pefloxacin: preparation, characterization, and dissolution profile.

Journal: Journal of pharmaceutical sciences 20080701

Title: Pharmacokinetics of pefloxacin and its metabolite norfloxacin in male and female ducks.

Journal: Journal of veterinary pharmacology and therapeutics 20080401

Title: Effect of trikatu pretreatment on the pharmacokinetics of pefloxacin administered orally in mountain Gaddi goats.

Journal: Journal of veterinary science 20080301

Title: Electroanalytical investigation and determination of pefloxacin in pharmaceuticals and serum at boron-doped diamond and glassy carbon electrodes.

Journal: Talanta 20080215

Title: Concentration-time courses of pefloxacin in plasma and milk of lactating she-camels (Camelus dromedarius).

Journal: Berliner und Munchener tierarztliche Wochenschrift 20080101

Title: Simultaneous determination of 13 quinolones in eggs using column high-performance liquid chromatography/electrospray ionization-tandem mass spectrometry and depletion of pefloxacin methanesulfonate in eggs.

Journal: Journal of AOAC International 20080101

Title: Chronic urticaria and monoclonal IgM gammopathy (Schnitzler syndrome): report of 11 cases treated with pefloxacin.

Journal: Archives of dermatology 20070801

Title: [Determination of 16 quinolone residues in animal tissues using high performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry].

Journal: Se pu = Chinese journal of chromatography 20070701

Title: Spectrophotometric determination of pefloxacin mesylate in pharmaceuticals.

Journal: Acta pharmaceutica (Zagreb, Croatia) 20070601

Title: Meta-analysis of prophylactic parenteral antibiotic use in acute necrotizing pancreatitis.

Journal: Medicina (Kaunas, Lithuania) 20070101

Title: [Chemotherapy activity and pharmacokinetics of the fluoroquinolones generics Ofloxacin-PhPO and Pefloxacin-genova].

Journal: Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] 20070101

Title: Preparation of anti-pefloxacin antibody and development of an indirect competitive enzyme-linked immunosorbent assay for detection of pefloxacin residue in chicken liver.

Journal: Journal of agricultural and food chemistry 20060920

Title: Quinolones for uncomplicated acute cystitis in women.

Journal: The Cochrane database of systematic reviews 20060719

Title: Age-dependent effects on redox status, oxidative stress, mitochondrial activity and toxicity induced by fluoroquinolones on primary cultures of rabbit tendon cells.

Journal: Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20060601

Title: Binding interactions of pefloxacin mesylate with bovine lactoferrin and human serum albumin.

Journal: Journal of Zhejiang University. Science. B 20060601

Title: Preparation and characterization of inclusion complexes of pefloxacin mesylate with three kinds of cyclodextrins.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20060501

Title: Residues of fluoroquinolone drugs in the cloacal gland and other tissues of Japanese quail.

Journal: British poultry science 20060201

Title: Quantitative determination of gatifloxacin, levofloxacin, lomefloxacin and pefloxacin fluoroquinolonic antibiotics in pharmaceutical preparations by high-performance liquid chromatography.

Journal: Journal of pharmaceutical and biomedical analysis 20060123

Title: Ion-activated, Gelrite-based in situ ophthalmic gels of pefloxacin mesylate: comparison with conventional eye drops.

Journal: Drug delivery 20060101

Title: Effects of pefloxacin in multi drug resistant typhoid fever.

Journal: Pakistan journal of pharmaceutical sciences 20060101

Title: [Intracranial hypertension in an infant treated with fluoroquinolone in Madagascar].

Journal: Archives de pediatrie : organe officiel de la Societe francaise de pediatrie 20051001

Title: Pharmacokinetics and tissue residues of pefloxacin and its metabolite norfloxacin in broiler chickens.

Journal: British poultry science 20051001

Title: Effects of pefloxacin in multi drug resistant typhoid Fever.

Journal: Pakistan journal of pharmaceutical sciences 20051001

Title: Ocular inserts for controlled delivery of pefloxacin mesylate: preparation and evaluation.

Journal: Acta pharmaceutica (Zagreb, Croatia) 20050901

Title: Spectroscopic and voltammetric studies of pefloxacin bound to calf thymus double-stranded DNA.

Journal: Analytical and bioanalytical chemistry 20050101

Title: A comparison of effects of fluoroquinolones on fracture healing (an experimental study in rats).

Journal: Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES 20050101

Title: [Properties of the Burkholderia pseudomallei insertional mutants deficient in membrane proteins production].

Journal: Molekuliarnaia genetika, mikrobiologiia i virusologiia 20050101

Title: Multiresidue determination of eleven quinolones in milk by liquid chromatography with fluorescence detection.

Journal: Journal of AOAC International 20050101

Title: [Susceptibility to norfloxacin of some bacterial strains causing urinary infections].

Journal: Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi 20050101

Title: A clinical trial of pefloxacin and ofloxacin in lepromatous leprosy.

Journal: Leprosy review 20041201

Title: Models for time-varying covariates in population pharmacokinetic-pharmacodynamic analysis.

Journal: British journal of clinical pharmacology 20041001

Title: Fluoroquinolones in children: poorly defined risk of joint damage.

Journal: Prescrire international 20041001

Title: [Study on fluorescence characteristics of pefloxacin-La(III) complex and its application].

Journal: Guang pu xue yu guang pu fen xi = Guang pu 20040901

Title: A three-way comparative study on the efficacy of twin sol to gel systems and marketed eye drops of pefloxacin mesylate.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20040801

Title: [The fluorescence characteristics of micelle inclusion of pefloxacin and its application].

Journal: Guang pu xue yu guang pu fen xi = Guang pu 20040701

Title: [Study on fluorescence characteristics of pefloxacin based on charge transfer reaction].

Journal: Guang pu xue yu guang pu fen xi = Guang pu 20040501

Title: Mechanisms of pefloxacin-induced pain.

Journal: Bulletin of experimental biology and medicine 20040401

Title: Extension of the isobolographic approach to interactions studies between more than two drugs: illustration with the convulsant interaction between pefloxacin, norfloxacin, and theophylline in rats.

Journal: Journal of pharmaceutical sciences 20040301

Title: Effect of pefloxacin on the urinary excretion of rifampicin.

Journal: American journal of therapeutics 20040101

Title: Some plasma and saliva pharmacokinetics parameters of rifampicin in the presence of pefloxacin.

Journal: American journal of therapeutics 20040101

Title: Activity of combinations of ceftazidime, imipenem and pefloxacin against Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa.

Journal: International journal of antimicrobial agents 20031201

Title: Fluoroquinolone-associated tendinopathy: a critical review of the literature.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20030601

Title: Pharmacokinetics and tissue penetration of pefloxacin plus metronidazole after administration as surgical prophylaxis in colorectal surgery.

Journal: International journal of clinical pharmacology and therapeutics 20030601

Title: The effect of nitric oxide combined with fluoroquinolones against Salmonella enterica serovar Typhimurium in vitro.

Journal: Memorias do Instituto Oswaldo Cruz 20030401

Title: [Study of filter-paper-substrate delay fluorescence of three quinolones].

Journal: Guang pu xue yu guang pu fen xi = Guang pu 20030401

Title: A microarray-based antibiotic screen identifies a regulatory role for supercoiling in the osmotic stress response of Escherichia coli.

Journal: Genome research 20030201

Title: [Drug sensitivity of Ureaplasma urealyticum, persisting in patients with chronic inflammatory diseases of the urogenital tract].

Journal: Zhurnal mikrobiologii, epidemiologii, i immunobiologii 20030101

Title: [Diagnosis and treatment of legionella pneumonia].

Journal: Pneumologie (Stuttgart, Germany) 20021101

Title: [Tenotoxic potential of fluoroquinolones in the choice of surgical antibiotic prophylaxis in ophthalmology].

Journal: Journal francais d'ophtalmologie 20021101

Title: Pharmacokinetics and tissue distribution of intravenous pefloxacin for antibiotic prophylaxis in biliary surgery.

Journal: Biopharmaceutics & drug disposition 20021001

Title: Some pharmacokinetic parameters of pefloxacin in lactating goats.

Journal: Veterinary research communications 20021001

Title: Spectrophotometric determination of enrofloxacin and pefloxacin through ion-pair complex formation.

Journal: Journal of pharmaceutical and biomedical analysis 20020401

Title: Mechanisms of resistance to fluoroquinolones in Coxiella burnetii.

Journal: The Journal of antimicrobial chemotherapy 20020201

Title: Pharmacokinetics of pefloxacin in goats after intravenous or oral administration.

Journal: Veterinary research communications 20020201

Title: Spectrophotometric determination of ciprofloxacin, enrofloxacin and pefloxacin through charge transfer complex formation.

Journal: Journal of pharmaceutical and biomedical analysis 20020101

Title: [Pefloxacin in the treatment of patients with mucoviscidosis].

Journal: Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] 20020101

Title: [On fluoroquinolones treatment safety in children (clinical, morphological and catamnesis data)].

Journal: Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] 20020101

Title: Microbial isolates in open fractures seen in the accident and emergency unit of a teaching hospital in a developing country.

Journal: West African journal of medicine 20020101

Title: [Pefloxacin (Abaktal)--efficacy in treating severe infections, optimization of treatment based on pharmacokinetic and pharmacodynamic parameters].

Journal: Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] 20020101

Title: [Efficacy of administration of 0.3% pefloxacin solution in the treatment of acute diffuse inflammation of the auditory canal].

Journal: Lijecnicki vjesnik 20020101

Title: In vitro selection of allosteric ribozymes: theory and experimental validation.

Journal: Journal of molecular biology 20011005

Title: [Study of pefloxacin concentration in blood and sputum in the aged pneumonia patients with impairment of renal function].

Journal: Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases 20011001

Title: Pefloxacin and ciprofloxacin increase UVA-induced edema and immune suppression.

Journal: Photodermatology, photoimmunology & photomedicine 20010801

Title: Interaction between biofilms formed by Staphylococcus epidermidis and quinolones.

Journal: Diagnostic microbiology and infectious disease 20010701

Title: [Application of new strategies in the treatment of patients with purulent sepsis complications].

Journal: Klinichna khirurhiia 20010701

Title: [An experimental study on the release of endotoxin from gram negative bacteria induced by antibiotics].

Journal: Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns 20010401

Title: Treatment of focal segmental glomerulosclerosis.

Journal: Current opinion in nephrology and hypertension 20010301

Title: Pharmacokinetics of pefloxacin and its interaction with cyclosporin A, a P-glycoprotein modulator, in rat blood, brain and bile, using simultaneous microdialysis.

Journal: British journal of pharmacology 20010301

Title: Pharmacokinetics of intravenously administered pefloxacin in the prostate; perspectives for its application in surgical prophylaxis.

Journal: International journal of antimicrobial agents 20010301

Title: Selective separation and simultaneous determination of trace levels of five types of fluorinated quinolone drugs by thin-layer chromatography/fluorescence densitometry.

Journal: Journal of AOAC International 20010101

Title: [Comparative efficacy and safety of ciprofloxacin, ofloxacin, and pefloxacin in treatment of respiratory infections in children with cystic fibrosis].

Journal: Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] 20010101

Title: [Effect of pefloxacin on immune response].

Journal: Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] 20010101

Title: [Pefloxacin (abactal) efficacy in severe pneumonia].

Journal: Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] 20010101

Title: [Efficacy of pefoxacin (abactal) in the complex treatment of patients with pancreonecrosis].

Journal: Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] 20010101

Title: Eradicative effect of cotrimoxazole and quinolones on non-typhoid salmonellae.

Journal: Bratislavske lekarske listy 20010101

Title: Comparative in-vitro activities of commonly available quinolones and other antibiotics on bacterial isolates in Ibadan, Nigeria.

Journal: African journal of medicine and medical sciences 20010101

Title: Pefloxacin in steroid dependent and resistant idiopathic nephrotic syndrome.

Journal: Journal of nephrology 20000101

Title: A new approach for early assessment of the epileptogenic potential of quinolones.

Journal: Antimicrobial agents and chemotherapy 19981001

Title: [Benign intracranial hypertension after treatment with pefloxacin].

Journal: Archives de pediatrie : organe officiel de la Societe francaise de pediatrie 19980801

Title: Interaction between pefloxacin and aminophylline in genetically epilepsy-prone rats.

Journal: The Journal of pharmacy and pharmacology 19971001

Title: Pefloxacin in adriamycin induced nephrotic syndrome in the rat.

Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 19970201

Title: [Surgically treated chronic bilateral Achilles tendon disease, without spontaneous rupture, caused by perfloxacin].

Journal: Presse medicale (Paris, France : 1983) 19960629

Title: An acute psychotic disorder caused by pefloxacin: a case report.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 19960201

Title: Clinical and microbiological evaluation of pefloxacin in lower respiratory tract infections.

Journal: The Journal of international medical research 19960101

Title: Grand mal seizures as a complication of treatment with pefloxacin in patients with cirrhosis. A report of three cases.

Journal: Journal of hepatology 19931101

Title: Peripheral neuropathy associated with fluoroquinolones.

Journal: Lancet (London, England) 19920711

Title: Multiple intra-articular treatment of rheumatoid arthritis: a randomized prospective study comparing rifamycin SV with pefloxacin.

Journal: The Journal of international medical research 19920201

Title: [Neurologic side effects of fluoroquinolones. Apropos of 9 cases concerning pefloxacin].

Journal: Therapie 19920101

Title: Non-nephrotoxic empiric antimicrobial therapy in febrile neutropenic cancer patients.

Journal: European journal of cancer (Oxford, England : 1990) 19920101

Title: Activities of pefloxacin and ofloxacin against mycobacteria: in vitro and mouse experiments.

Journal: Tubercle 19910301

Title: Central nervous system toxicity of quinolones: human and animal findings.

Journal: The Journal of antimicrobial chemotherapy 19901001

Title: Pefloxacin: safety in man.

Journal: The Journal of antimicrobial chemotherapy 19901001

Title: Epileptic attacks associated with pefloxacin treatment in a patient on CAPD.

Journal: Clinical nephrology 19890701

Title: [In vitro determination of the sensitivity of mycobacteria to fluoroquinolones].

Journal: Pathologie-biologie 19890501

Title: Comparative antimycobacterial activities of difloxacin, temafloxacin, enoxacin, pefloxacin, reference fluoroquinolones, and a new macrolide, clarithromycin.

Journal: Antimicrobial agents and chemotherapy 19890401

Title: In vitro activity of pefloxacin compared with five other quinolones on nalidixic acid-resistant proteae species.

Journal: Chemioterapia : international journal of the Mediterranean Society of Chemotherapy 19881001

Title: Neurological toxicity related to pefloxacin.

Journal: The Journal of antimicrobial chemotherapy 19880601

Title: Efficacy of pefloxacin-fosfomycin in experimental endocarditis caused by methicillin-resistant Staphylococcus aureus.

Journal: Antimicrobial agents and chemotherapy 19880601

Title: Activity of five fluoroquinolones against Mycobacterium avium-intracellulare complex and M. xenopi.

Journal: Annales de l'Institut Pasteur. Microbiology 19880101

Title: In vitro activity of five new quinolones against cultivable mycobacteria.

Journal: European journal of clinical microbiology 19871001

Title: In vitro activity of four fluoroquinolones against eighty-six isolates of mycobacteria.

Journal: European journal of clinical microbiology 19871001

Title: Critical risk/benefit analysis of pefloxacine use in children under 15 years--the problem of arthralgias.

Journal: International journal of clinical pharmacology, therapy, and toxicology 19870601

Title: Comparative in-vitro activity of five fluoroquinolones against mycobacteria.

Journal: The Journal of antimicrobial chemotherapy 19870501

Title: Drlica K, et al. DNA gyrase, topoisomerase IV, and the 4-quinolones. Microbiol Mol Biol Rev. 1997 Sep;61(3):377-92.

Title: Hussy P, et al. Effect of 4-quinolones and novobiocin on calf thymus DNA polymerase alpha primase complex, topoisomerases I and II, and growth of mammalian lymphoblasts. Antimicrob Agents Chemother. 1986 Jun;29(6):1073-8.

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Tags:149676-40-4 Molecular Formula|149676-40-4 MDL|149676-40-4 SMILES|149676-40-4 1-ETHYL-6-FLUORO-7-(4-METHYLPIPERAZIN-1-YL)-4-OXO-QUINOLINE-3-CARBOXYLIC ACID