[1]Patent:WO2008/72190,2008,A2.Locationinpatent:Page/Pagecolumn15
[2]Patent:WO2008/72190,2008,A2.Locationinpatent:Page/Pagecolumn15-16
149888-94-8
[1]Patent:WO2008/72190,2008,A2.Locationinpatent:Page/Pagecolumn16
149888-94-8
[1]Patent:WO2008/72190,2008,A2.Locationinpatent:Page/Pagecolumn16
Title: A mechanism underlying compound-induced voltage shift in the current activation of hERG by antiarrhythmic agents.
Journal: Biochemical and biophysical research communications 20111111
Title: I(Kr) vs. I(Ks) blockade and arrhythmogenicity in normoxic rabbit Purkinje fibers: does it really make a difference?
Journal: Fundamental & clinical pharmacology 20110601
Title: [The research practice of anti-arrhythmic agents targeting on potassium ion channel].
Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20110101
Title: Inhibitory effect of azimilide on Na+/Ca2+ exchange current in guinea-pig cardiac myocytes.
Journal: Journal of pharmacological sciences 20100101
Title: Azimilide reduces emergency department visits and hospitalizations in patients with an implantable cardioverter-defibrillator in a placebo-controlled clinical trial.
Journal: Journal of the American College of Cardiology 20080923
Title: Azimilide: another effort to prevent implantable cardioverter-defibrillator shocks and their sequelae why it is important and how it works.
Journal: Journal of the American College of Cardiology 20080923
Title: New horizons in antiarrhythmic therapy: will novel agents overcome current deficits?
Journal: The American journal of cardiology 20080922
Title: Role of drug therapy for sustained ventricular tachyarrhythmias.
Journal: Cardiology clinics 20080801
Title: Update on atrial fibrillation: part II.
Journal: Clinical cardiology 20080301
Title: Azimilide for the treatment of atrial fibrillation, atrial flutter, and paroxysmal supraventricular tachycardia: results of a randomized trial and insights on the concordance of symptoms and recurrent arrhythmias.
Journal: Journal of cardiovascular electrophysiology 20080201
Title: The additive effects of the active component of grapefruit juice (naringenin) and antiarrhythmic drugs on HERG inhibition.
Journal: Cardiology 20080101
Title: Relationship among amiodarone, new class III antiarrhythmics, miscellaneous agents and acquired long QT syndrome.
Journal: Cardiology journal 20080101
Title: The impact of acute myocardial ischemia on the ventricular defibrillation threshold during chronic oral azimilide therapy.
Journal: Journal of cardiovascular pharmacology 20071201
Title: Effects of azimilide on the muscarinic acetylcholine receptor-operated K+ current and experimental atrial fibrillation in guinea-pig hearts.
Journal: Journal of pharmacological sciences 20071101
Title: Adjunctive therapy for recurrent ventricular tachycardia in patients with implantable cardioverter defibrillators.
Journal: Current cardiology reports 20070901
Title: QT Interval prolongation and torsades de pointes due to a coadministration of ciprofloxacin and azimilide in a patient with implantable cardioverter-defibrillator.
Journal: Pacing and clinical electrophysiology : PACE 20070801
Title: Antiarrhythmic drugs: present and future.
Journal: The Journal of the Association of Physicians of India 20070401
Title: L-type calcium current reactivation contributes to arrhythmogenesis associated with action potential triangulation.
Journal: Journal of cardiovascular electrophysiology 20070201
Title: Action potential and QT prolongation not sufficient to cause Torsade de Pointes: role of action potential triangulation.
Journal: Journal of cardiovascular electrophysiology 20070201
Title: The effect of high extracellular potassium on IKr inhibition by anti-arrhythmic agents.
Journal: Cardiology 20070101
Title: Electrical storm in patients with an implantable defibrillator: incidence, features, and preventive therapy: insights from a randomized trial.
Journal: European heart journal 20061201
Title: Azimilide vs. placebo and sotalol for persistent atrial fibrillation: the A-COMET-II (Azimilide-CardiOversion MaintEnance Trial-II) trial.
Journal: European heart journal 20060901
Title: Cumulative experience of azimilide-associated torsades de pointes ventricular tachycardia in the 19 clinical studies comprising the azimilide database.
Journal: Journal of the American College of Cardiology 20060801
Title: Efficacy of azimilide for the maintenance of sinus rhythm in patients with paroxysmal atrial fibrillation in the presence and absence of structural heart disease.
Journal: The American journal of cardiology 20060715
Title: Electrophysiological and antiarrhythmic effects of the novel antiarrhythmic agent AZD7009: a comparison with azimilide and AVE0118 in the acutely dilated right atrium of the rabbit in vitro.
Journal: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 20060701
Title: Antiarrhythmic efficacy of azimilide in patients with atrial fibrillation. Maintenance of sinus rhythm after conversion to sinus rhythm.
Journal: American heart journal 20060501
Title: Characterization of the in vivo and in vitro electrophysiological effects of the novel antiarrhythmic agent AZD7009 in atrial and ventricular tissue of the dog.
Journal: Journal of cardiovascular pharmacology 20060101
Title: The metabolic profile of azimilide in man: in vivo and in vitro evaluations.
Journal: Journal of pharmaceutical sciences 20050901
Title: Electrophysiological effects of azimilide in an in vitro model of simulated-ischemia and reperfusion in guinea-pig ventricular myocardium.
Journal: European journal of pharmacology 20050822
Title: Assessment of the proarrhythmic potential of the novel antiarrhythmic agent AZD7009 and dofetilide in experimental models of torsades de pointes.
Journal: Journal of cardiovascular electrophysiology 20050801
Title: Application of Raman spectroscopy for on-line monitoring of low dose blend uniformity.
Journal: International journal of pharmaceutics 20050714
Title: Influence of coadministration on the pharmacokinetics of azimilide dihydrochloride and digoxin.
Journal: Journal of clinical pharmacology 20050701
Title: Azimilide dihydrochloride.
Journal: Expert review of cardiovascular therapy 20050501
Title: The influence of extracellular acidosis on the effect of IKr blockers.
Journal: Journal of cardiovascular pharmacology and therapeutics 20050301
Title: Design of the SHock Inhibition Evaluation with Azimilide (SHIELD) study: a novel method to assess antiarrhythmic drug effect in patients with an implantable cardioverter-defibrillator.
Journal: The American journal of cardiology 20050115
Title: Placebo-controlled, randomized clinical trial of azimilide for prevention of ventricular tachyarrhythmias in patients with an implantable cardioverter defibrillator.
Journal: Circulation 20041214
Title: The shocking story of azimilide.
Journal: Circulation 20041214
Title: Influence of ketoconazole on azimilide pharmacokinetics in healthy subjects.
Journal: British journal of clinical pharmacology 20041201
Title: Advantages and pitfalls of combining device-based and pharmacologic therapies for the treatment of ventricular arrhythmias: observations from a tertiary referral center.
Journal: Pacing and clinical electrophysiology : PACE 20041201
Title: A benefit-risk assessment of class III antiarrhythmic agents.
Journal: Expert opinion on drug safety 20041101
Title: State-dependent blocking actions of azimilide dihydrochlo-ride (NE-10064) on human cardiac Na(+) channels.
Journal: Circulation journal : official journal of the Japanese Circulation Society 20040701
Title: Atrial-selective antiarrhythmic actions of novel Ikur vs. Ikr, Iks, and IKAch class Ic drugs and beta blockers in pigs.
Journal: Medical science monitor : international medical journal of experimental and clinical research 20040701
Title: Effect of mild and moderate hepatic impairment on azimilide pharmacokinetics following single dose oral administration.
Journal: Journal of pharmaceutical sciences 20040501
Title: Acidification alters antiarrhythmic drug blockade of the ether-a-go-go-related Gene (HERG) Channels.
Journal: Basic & clinical pharmacology & toxicology 20040501
Title: The efficacy of azimilide in the treatment of atrial fibrillation in the presence of left ventricular systolic dysfunction: results from the Azimilide Postinfarct Survival Evaluation (ALIVE) trial.
Journal: Journal of the American College of Cardiology 20040407
Title: Influence of azimilide on CYP2C19-mediated metabolism.
Journal: Journal of clinical pharmacology 20040401
Title: Mortality in patients after a recent myocardial infarction: a randomized, placebo-controlled trial of azimilide using heart rate variability for risk stratification.
Journal: Circulation 20040302
Title: Azimilide decreases recurrent ventricular tachyarrhythmias in patients with implantable cardioverter defibrillators.
Journal: Journal of the American College of Cardiology 20040107
Title: Oral class III antiarrhythmics: what is new?
Journal: Current opinion in cardiology 20040101
Title: Trials of new antiarrhythmic drugs for maintenance of sinus rhythm in patients with atrial fibrillation.
Journal: Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing 20040101
Title: Recent developments in cardiovascular drug therapy: treatment of atrial arrhythmias with new class III drugs and beyond.
Journal: Current medicinal chemistry. Cardiovascular and hematological agents 20040101
Title: [Progress in the clinical use of anti-arrhythmic drugs (I)].
Journal: Zhonghua er ke za zhi = Chinese journal of pediatrics 20031001
Title: Symptoms at the time of arrhythmia recurrence in patients receiving azimilide for control of atrial fibrillation or flutter: results from randomized trials.
Journal: American heart journal 20030901
Title: Pure class III agents for prevention of sudden cardiac death.
Journal: Journal of cardiovascular electrophysiology 20030901
Title: Azimilide for atrial fibrillation: clinical trial results and implications.
Journal: Cardiac electrophysiology review 20030901
Title: Multiple cellular electrophysiological effects of azimilide in canine cardiac preparations.
Journal: European journal of pharmacology 20030606
Title: Preserved effects of potassium channel blockers in the pacing-induced remodeled canine atrium: a comparison between E4031 and azimilide.
Journal: Journal of cardiovascular pharmacology 20030501
Title: Risk of proarrhythmia with class III antiarrhythmic agents: sex-based differences and other issues.
Journal: The American journal of cardiology 20030320
Title: Asymptomatic or 'silent' atrial fibrillation: frequency in untreated patients and patients receiving azimilide.
Journal: Circulation 20030304
Title: Block of erg current by linoleoylamide, a sleep-inducing agent, in pituitary GH3 cells.
Journal: European journal of pharmacology 20030101
Title: Electrophysiological and antiarrhythmic effects of the novel I(Kur) channel blockers, S9947 and S20951, on left vs. right pig atrium in vivo in comparison with the I(Kr) blockers dofetilide, azimilide, d,l-sotalol and ibutilide.
Journal: Naunyn-Schmiedeberg's archives of pharmacology 20021101
Title: Effect of severe renal impairment on the pharmacokinetics of azimilide following single dose oral administration.
Journal: British journal of clinical pharmacology 20021101
Title: [Drug therapy of ventricular arrhythmias - a contemporary perspective].
Journal: Deutsche medizinische Wochenschrift (1946) 20021025
Title: The effect of isoproterenol on the class III effect of azimilide in humans.
Journal: Journal of cardiovascular pharmacology and therapeutics 20021001
Title: Azimilide inhibits multiple cardiac potassium currents in human atrial myocytes.
Journal: Journal of cardiovascular pharmacology and therapeutics 20021001
Title: [Current strategies of pharmacological and non-pharmacological treatment in atrial fibrillation and atrial flutter].
Journal: Nihon rinsho. Japanese journal of clinical medicine 20020701
Title: Antiarrhythmic effects of azimilide in paroxysmal supraventricular tachycardia: efficacy and dose-response.
Journal: American heart journal 20020401
Title: Effects of azimilide on heart rate and ECG conduction intervals during sinus rhythm in patients with a history of atrial fibrillation.
Journal: Journal of clinical pharmacology 20020401
Title: New antiarrhythmic drugs for the treatment of atrial fibrillation.
Journal: Pacing and clinical electrophysiology : PACE 20020201
Title: Cardiovascular news.
Journal: Circulation 20011127
Title: Dose-response relations of azimilide in the management of symptomatic, recurrent, atrial fibrillation.
Journal: The American journal of cardiology 20011101
Title: Interaction of azimilide with neurohumoral and channel receptors.
Journal: Biochemical pharmacology 20011001
Title: A population pharmacokinetic-pharmacodynamic analysis and model validation of azimilide.
Journal: Clinical pharmacology and therapeutics 20011001
Title: Is it rational, reasonable or excessive, and consistently applied? One view of the increasing FDA emphasis on safety first for the release and use of antiarrhythmic drugs for supraventricular arrhythmias.
Journal: Journal of cardiovascular pharmacology and therapeutics 20011001
Title: Efficacy of azimilide and dofetilide in the dog right atrial enlargement model of atrial flutter.
Journal: Journal of cardiovascular electrophysiology 20010901
Title: Effects of azimilide, a new class III antiarrhythmic drug, on reentrant circuits causing ventricular tachycardia and fibrillation in a canine model of myocardial infarction.
Journal: Journal of cardiovascular electrophysiology 20010901
Title: Phase 2 early afterdepolarization as a trigger of polymorphic ventricular tachycardia in acquired long-QT syndrome : direct evidence from intracellular recordings in the intact left ventricular wall.
Journal: Circulation 20010612
Title: Azimilide and dofetilide produce similar electrophysiological and proarrhythmic effects in a canine model of Torsade de Pointes arrhythmias.
Journal: European journal of pharmacology 20010119
Title: Newer antiarrhythmic drugs.
Journal: Indian heart journal 20010101
Title: New antiarrhythmic agents for atrial fibrillation.
Journal: Current opinion in investigational drugs (London, England : 2000) 20010101
Title: Azimilide dihydrochloride: a new class III anti-arrhythmic agent.
Journal: Expert opinion on investigational drugs 20001101
Title: Effects of azimilide, a KV(r) and KV(s) blocker, on canine ventricular arrhythmia models.
Journal: European journal of pharmacology 19990702
Title: Azimilide dihydrochloride: a unique class III antiarrhythmic agent.
Journal: Heart disease (Hagerstown, Md.) 19990101
Title: The azimilide post-infarct survival evaluation (ALIVE) trial.
Journal: The American journal of cardiology 19980319
Title: Inhibition of isoproterenol-induced tachycardia by azimilide in the isolated perfused guinea pig heart.
Journal: Cardiovascular drugs and therapy 19980301
Title: The role of the IsK protein in the specific pharmacological properties of the IKs channel complex.
Journal: British journal of pharmacology 19970901
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