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151-73-5,MFCD00200361
Catalog No.:AA003O3J

151-73-5 | Betamethasone 21-disodium phosphate

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50mg
98%(HPLC)
in stock  
$80.00   $56.00
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250mg
98%(HPLC)
in stock  
$189.00   $133.00
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1g
>98.0%(T)(HPLC)
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$255.00   $179.00
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  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA003O3J
Chemical Name:
Betamethasone 21-disodium phosphate
CAS Number:
151-73-5
Molecular Formula:
C22H28FNa2O8P
Molecular Weight:
516.4046
MDL Number:
MFCD00200361
SMILES:
O=C1C=C[C@]2(C(=C1)CC[C@@H]1[C@]2(F)[C@@H](O)C[C@]2([C@H]1C[C@@H]([C@]2(O)C(=O)COP(=O)([O-])[O-])C)C)C.[Na+].[Na+]
Properties
Properties
 
BP:
669.6°C at 760 mmHg  
Form:
Solid  
MP:
206-211°C  
Storage:
Inert atmosphere;Room Temperature;  

Computed Properties
 
Complexity:
962  
Covalently-Bonded Unit Count:
3  
Defined Atom Stereocenter Count:
8  
Heavy Atom Count:
34  
Hydrogen Bond Acceptor Count:
9  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
3  

Literature

Title: Poly (N-isopropylacrylamide)-PLA and PLA blend nanoparticles for temperature-controllable drug release and intracellular uptake.

Journal: Colloids and surfaces. B, Biointerfaces 20121101

Title: Pharmacokinetics of betamethasone after single-dose intramuscular administration of betamethasone phosphate and betamethasone acetate to healthy subjects.

Journal: Clinical therapeutics 20120101

Title: Determination of the particulate size and aggregation of clonidine and corticosteroids for epidural steroid injection.

Journal: Pain physician 20120101

Title: An anatomically based approach to intralesional corticosteroid injection for eyelid capillary hemangiomas.

Journal: Ophthalmic surgery, lasers & imaging : the official journal of the International Society for Imaging in the Eye 20120101

Title: Monomorphous papulopustular rash - a case study.

Journal: Australian family physician 20111201

Title: Role of greater occipital nerve blocks and trigger point injections for patients with dizziness and headache.

Journal: The neurologist 20111101

Title: Beneficial pharmacological effects of selective glucocorticoid receptor agonist in external eye diseases.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20110801

Title: Comparison of therapeutic results in sudden sensorineural hearing loss with/without additional hyperbaric oxygen therapy: a retrospective review of 465 audiologically controlled cases.

Journal: Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery 20110401

Title: Therapeutic effect of stealth-type polymeric nanoparticles with encapsulated betamethasone phosphate on experimental autoimmune uveoretinitis.

Journal: Investigative ophthalmology & visual science 20110318

Title: Pharmacokinetic features of difluprednate ophthalmic emulsion in rabbits as determined by glucocorticoid receptor-binding bioassay.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20110201

Title: Pharmacokinetics of betamethasone and betamethasone 17-monopropionate in Chinese healthy volunteers after intramuscular injection of betamethasone phosphate/betamethasone dipropionate.

Journal: Arzneimittel-Forschung 20110101

Title: A stability-indicating reversed-phase high performance liquid chromatography method for simultaneous assay of two corticosteroids and estimation of their related compounds in a pharmaceutical injectable formulation.

Journal: Journal of chromatography. A 20101029

Title: Preparation and characterization of a nanoparticulate formulation composed of PEG-PLA and PLA as anti-inflammatory agents.

Journal: International journal of pharmaceutics 20100129

Title: Betamethasone dose and formulation for induced lung maturation in fetal sheep.

Journal: American journal of obstetrics and gynecology 20091201

Title: Use of liquid chromatography/tandem mass spectrometric molecular fingerprinting for the rapid structural identification of pharmaceutical impurities.

Journal: Rapid communications in mass spectrometry : RCM 20091101

Title: Polymeric nanoparticles encapsulating betamethasone phosphate with different release profiles and stealthiness.

Journal: International journal of pharmaceutics 20090622

Title: Comparison of ultrasound-, palpation-, and scintigraphy-guided steroid injections in the treatment of plantar fasciitis.

Journal: Archives of orthopaedic and trauma surgery 20090501

Title: Treatment of experimental arthritis with stealth-type polymeric nanoparticles encapsulating betamethasone phosphate.

Journal: The Journal of pharmacology and experimental therapeutics 20090501

Title: An atypical case of microcysts associated with silicone hydrogel contact lens: findings on in vivo confocal laser microscopy.

Journal: Eye & contact lens 20090501

Title: Forced degradation of betamethasone sodium phosphate under solid state: Formation, characterization, and mechanistic study of all four 17,20-diastereomers of betamethasone 17-deoxy-20-hydroxy-21-oic acid.

Journal: Journal of pharmaceutical sciences 20090301

Title: [Effect of preservative-free betamethasone sodium phosphate eyedrops on the development of corneal epithelial disorders after penetrating keratoplasty].

Journal: Nippon Ganka Gakkai zasshi 20090201

Title: Efficient encapsulation of a water-soluble corticosteroid in biodegradable nanoparticles.

Journal: International journal of pharmaceutics 20090105

Title: A double-blind randomised clinical trial of the treatment of otitis externa using topical steroid alone versus topical steroid-antibiotic therapy.

Journal: European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 20090101

Title: The effect of intra-articular injection of betamethasone acetate/betamethasone sodium phosphate on blood glucose levels in controlled diabetic patients with symptomatic osteoarthritis of the knee.

Journal: Clinical rheumatology 20090101

Title: Effects of human amniotic fluid and membrane in the treatment of Achilles tendon ruptures in locally corticosteroid-induced Achilles tendinosis: an experimental study on rats.

Journal: Foot and ankle surgery : official journal of the European Society of Foot and Ankle Surgeons 20090101

Title: Effect of betamethasone phosphate loaded polymeric nanoparticles on a murine asthma model.

Journal: Cellular immunology 20090101

Title: The role of sacroiliac joint dysfunction in the genesis of low back pain: the obvious is not always right.

Journal: Archives of orthopaedic and trauma surgery 20071201

Title: Betamethasone for lung maturation: testing dose and formulation in fetal sheep.

Journal: American journal of obstetrics and gynecology 20071101

Title: Hemin, an inducer of heme oxygenase-1, lowers intraocular pressure in rabbits.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20070601

Title: Conservative treatment for a symptomatic solitary ganglion cyst of the anterior meniscus invading into the infrapatellar fat pad.

Journal: Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA 20070301

Title: [Treatment of generalized cutaneous lichen planus with dipropionate and betamethasone disodium phosphate: an open study of 73 cases].

Journal: Annales de dermatologie et de venereologie 20070301

Title: [Diagnosis of and therapy for eosinophilic otitis media and paranasal sinusitis--preservation therapy for eosinophilic otitis media according to the classification].

Journal: Nihon Jibiinkoka Gakkai kaiho 20070301

Title: Comparison of the particle sizes of different steroids and the effect of dilution: a review of the relative neurotoxicities of the steroids.

Journal: Anesthesiology 20070201

Title: Anaphylaxis induced by intramuscular betamethasone disodium phosphate: reflections on a clinical case.

Journal: International journal of immunopathology and pharmacology 20070101

Title: Topical ocular drug delivery to inner ear disease and sinusitis.

Journal: Southern medical journal 20061101

Title: Kinetics of betamethasone and fetal cardiovascular adverse effects in pregnant sheep after different doses.

Journal: Obstetrics and gynecology 20060901

Title: Immediate allergic reaction to betamethasone during anesthesia.

Journal: Anesthesia and analgesia 20060601

Title: Treatment of experimental autoimmune uveoretinitis with poly(lactic acid) nanoparticles encapsulating betamethasone phosphate.

Journal: Experimental eye research 20060401

Title: Topical steroid and antibiotic combination therapy in red eye conditions.

Journal: The British journal of general practice : the journal of the Royal College of General Practitioners 20060401

Title: Single perioperative triamcinolone injection versus standard postoperative steroid drops after uneventful phacoemulsification surgery: Randomized controlled trial.

Journal: Journal of cataract and refractive surgery 20060301

Title: A prospective randomized blinded cross-over trial using nasal drops in patients with nasal polyposis: an evaluation of effectiveness and comfort level of two head positions.

Journal: American journal of rhinology 20060101

Title: Clinical outcome of extrasynovial steroid injection for trigger finger.

Journal: Hand surgery : an international journal devoted to hand and upper limb surgery and related research : journal of the Asia-Pacific Federation of Societies for Surgery of the Hand 20060101

Title: [Safety and usefulness of the long-term intranasal topical treatment with steroids for olfactory dysfunction].

Journal: Nihon Jibiinkoka Gakkai kaiho 20051001

Title: Treatment of experimental arthritis with poly(D, L-lactic/glycolic acid) nanoparticles encapsulating betamethasone sodium phosphate.

Journal: Annals of the rheumatic diseases 20050801

Title: Betamethasone pharmacokinetics after two prodrug formulations in sheep: implications for antenatal corticosteroid use.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20050801

Title: Intralesional steroid injection for management of acute idiopathic dacryoadenitis: a preliminary result.

Journal: Ophthalmic plastic and reconstructive surgery 20050301

Title: Effect of benzalkonium chloride on transscleral drug delivery.

Journal: Investigative ophthalmology & visual science 20050201

Title: Betamethasone sodium phosphate.

Journal: Nursing times 20041201

Title: Efficacy and systemic tolerability of mometasone furoate and betamethasone sodium phosphate.

Journal: The Journal of laryngology and otology 20041101

Title: [Prognosis in olfaction disorders].

Journal: Nihon Jibiinkoka Gakkai kaiho 20041001

Title: Ototoxicity after use of neomycin eardrops is unrelated to A1555G point mutation in mitochondrial DNA.

Journal: The Journal of laryngology and otology 20040701

Title: Intralesional 5-fluorouracil in the treatment of keloid scars.

Journal: The Australasian journal of dermatology 20040501

Title: Corticosteroid treatment of experimental arthritis retards cartilage destruction as determined by histology and serum COMP.

Journal: Rheumatology (Oxford, England) 20040401

Title: Long-term use of corticosteroid eye drops delays the spontaneous remission of pulmonary sarcoidosis.

Journal: The Tohoku journal of experimental medicine 20040401

Title: Cataract and glaucoma after wear of contact lens soaked in steroid solution: a rare complication.

Journal: Eye & contact lens 20040401

Title: Stabilization and HPLC analysis of betamethasone sodium phosphate in plasma.

Journal: Journal of pharmaceutical sciences 20040301

Title: Venous thromboembolism in pregnancy. A case report of deep venous thrombosis (DVT) in puerperium.

Journal: Clinical and experimental obstetrics & gynecology 20040101

Title: Induction of apoptosis in nasal polyp fibroblasts by glucocorticoids in vitro.

Journal: Acta oto-laryngologica 20031201

Title: Patient-centred outcome measures for oral mucosal disease are sensitive to treatment.

Journal: International journal of oral and maxillofacial surgery 20030601

Title: SubTenon's infusion of steroids for treatment of orbital hemangiomas.

Journal: Ophthalmology 20030601

Title: Acute anterior uveitis.

Journal: Clinical evidence 20030601

Title: Biodegradable intrascleral implant for sustained intraocular delivery of betamethasone phosphate.

Journal: Investigative ophthalmology & visual science 20030201

Title: Immediate and delayed effects of antenatal corticosteroids on fetal heart rate: a randomized trial that compares betamethasone acetate and phosphate, betamethasone phosphate, and dexamethasone.

Journal: American journal of obstetrics and gynecology 20030201

Title: Water-soluble betamethasone-loaded poly(lactide-co-glycolide) hollow microparticles as a sustained release dosage form.

Journal: Journal of microencapsulation 20030101

Title: The effect of a glucocorticoid on olfactory response of isolated mouse olfactory cells.

Journal: In vivo (Athens, Greece) 20030101

Title: Fluticasone propionate spray and betamethasone sodium phosphate mouthrinse: a randomized crossover study for the treatment of symptomatic oral lichen planus.

Journal: Journal of the American Academy of Dermatology 20020801

Title: Immunochemical characterization and measurement of neuronal type nitric oxide synthase in human neuroblastoma NB-OK-1 cell using novel anti-synthetic peptide antibody and specific immunoassay system.

Journal: Regulatory peptides 20020615

Title: Prolonged anti-inflammatory action of DL-lactide/glycolide copolymer nanospheres containing betamethasone sodium phosphate for an intra-articular delivery system in antigen-induced arthritic rabbit.

Journal: Pharmaceutical research 20020401

Title: Intentional ablation of vestibular function using commercially available topical gentamicin-betamethasone eardrops in patients with Meniere's disease: further evidence for topical eardrop ototoxicity.

Journal: The Laryngoscope 20020401

Title: Most patients overdose on topical nasal corticosteroid drops: an accurate delivery device is required.

Journal: The Journal of laryngology and otology 20020201

Title: Effects of antiinflammatory drugs on migration of the rabbit corneal epithelium.

Journal: Journal of cataract and refractive surgery 20010901

Title: High injection pressure during intralesional injection of corticosteroids into capillary hemangiomas.

Journal: Archives of ophthalmology (Chicago, Ill. : 1960) 20010501

Title: Orbital mass following injection with depot corticosteroids.

Journal: Canadian journal of ophthalmology. Journal canadien d'ophtalmologie 20010401

Title: Two cases of frosted branch angiitis with central retinal vein occlusion.

Journal: Japanese journal of ophthalmology 20010101

Title: [Betamethasone Sodium Phosphate Reference Standard (Control 001) of National Institute of Health Sciences].

Journal: Kokuritsu Iyakuhin Shokuhin Eisei Kenkyujo hokoku = Bulletin of National Institute of Health Sciences 20010101

Title: Adrenal suppression with intranasal betamethasone drops.

Journal: The Journal of laryngology and otology 19920901

Title: Experimental corticosteroid myopathy.

Journal: Acta neuropathologica 19810101

Title: Occlusion of the central retinal artery after retrobulbar corticosteroid injection.

Journal: American journal of ophthalmology 19780301

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