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151342-35-7,MFCD01319127
Catalog No.:AA001N81

151342-35-7 | 1H-Pyrrole-2,5-dione, 3-[(8S)-8-[(dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methyl-1H-indol-3-yl)-

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1mg
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  • Technical Information
  • Properties
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Technical Information
Catalog Number:
AA001N81
Chemical Name:
1H-Pyrrole-2,5-dione, 3-[(8S)-8-[(dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methyl-1H-indol-3-yl)-
CAS Number:
151342-35-7
Molecular Formula:
C28H28N4O2
Molecular Weight:
452.5475
MDL Number:
MFCD01319127
SMILES:
CN(C[C@H]1CCn2c(C1)c(C1=C(C(=O)NC1=O)c1cn(c3c1cccc3)C)c1c2cccc1)C
Properties
Properties
 
Form:
Solid  

Computed Properties
 
Complexity:
869  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
34  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
4  
XLogP3:
3.4  

Literature

Title: Tributyltin exposure at noncytotoxic doses dysregulates pancreatic β-cell function in vitro and in vivo.

Journal: Archives of toxicology 20170901

Title: Aldosterone activates transcription factor Nrf2 in kidney cells both in vitro and in vivo.

Journal: Antioxidants & redox signaling 20141120

Title: A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.

Journal: The Biochemical journal 20130415

Title: C1B domain peptide of protein kinase Cγ significantly suppresses growth of human colon cancer cells in vitro and in an in vivo mouse xenograft model through induction of cell cycle arrest and apoptosis.

Journal: Cancer biology & therapy 20120801

Title: Intermittent PTH(1-34) signals through protein kinase A to regulate osteoprotegerin production in human periodontal ligament cells in vitro.

Journal: Clinical oral investigations 20120401

Title: Ezrin, radixin, and moesin are phosphorylated in response to 2-methoxyestradiol and modulate endothelial hyperpermeability.

Journal: American journal of respiratory cell and molecular biology 20111201

Title: Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity.

Journal: Nature biotechnology 20111101

Title: Intermittent administration of PTH(1-34) regulates the osteoblastic differentiation of human periodontal ligament cells via protein kinase C- and protein kinase A-dependent pathways in vitro.

Journal: Journal of periodontal research 20110601

Title: Glycogen synthase kinase-3β is a crucial mediator of signal-induced RelB degradation.

Journal: Oncogene 20110526

Title: VEGFR1 and PKCα signaling control melanoma vasculogenic mimicry in a VEGFR2 kinase-independent manner.

Journal: Melanoma research 20110401

Title: Mechanism for carbachol-induced secretion of lacritin in cultured monkey lacrimal acinar cells.

Journal: Investigative ophthalmology & visual science 20100901

Title: Nitric oxide protects the heart from ischemia-induced apoptosis and mitochondrial damage via protein kinase G mediated blockage of permeability transition and cytochrome c release.

Journal: Journal of biomedical science 20090101

Title: Inhibitory effect of xanthones isolated from the pericarp of Garcinia mangostana L. on rat basophilic leukemia RBL-2H3 cell degranulation.

Journal: Bioorganic & medicinal chemistry 20080415

Title: Negative regulation of cyclin-dependent kinase 5 targets by protein kinase C.

Journal: European journal of pharmacology 20080310

Title: Role of phospholipase Cgamma-induced activation of protein kinase Cepsilon (PKCepsilon) and PKCbetaI in epidermal growth factor-mediated protection of tight junctions from acetaldehyde in Caco-2 cell monolayers.

Journal: The Journal of biological chemistry 20080208

Title: Trace amine-associated receptor 1 is a modulator of the dopamine transporter.

Journal: The Journal of pharmacology and experimental therapeutics 20070401

Title: Protein kinase C inhibition attenuates vascular ETB receptor upregulation and decreases brain damage after cerebral ischemia in rat.

Journal: BMC neuroscience 20070101

Title: VCAM-1 signals activate endothelial cell protein kinase Calpha via oxidation.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20061101

Title: Pharmacological- and gene therapy-based inhibition of protein kinase Calpha/beta enhances cardiac contractility and attenuates heart failure.

Journal: Circulation 20060808

Title: Enhancement of tumor invasion depends on transdifferentiation of skin fibroblasts mediated by reactive oxygen species.

Journal: Journal of cell science 20060701

Title: Evidence that phospholipase-C-dependent, calcium-independent mechanisms are required for directional migration of T-lymphocytes in response to the CCR4 ligands CCL17 and CCL22.

Journal: Journal of leukocyte biology 20060601

Title: Involvement of protein kinase C in crystalline silica-induced activation of the MAP kinase and AP-1 pathway.

Journal: American journal of physiology. Lung cellular and molecular physiology 20060201

Title: Phosphorylation of coronin 1B by protein kinase C regulates interaction with Arp2/3 and cell motility.

Journal: The Journal of biological chemistry 20050909

Title: Stimulation of catecholamine biosynthesis via the PKC pathway by prolactin-releasing peptide in PC12 rat pheochromocytoma cells.

Journal: The Journal of endocrinology 20050701

Title: Nongenomic effect of thyroid hormone on free-radical production in human polymorphonuclear leukocytes.

Journal: The Journal of endocrinology 20050401

Title: Activation of cardiac human ether-a-go-go related gene potassium currents is regulated by alpha(1A)-adrenoceptors.

Journal: Journal of molecular medicine (Berlin, Germany) 20041201

Title: Facilitation of noradrenaline release by activation of adenosine A(2A) receptors triggers both phospholipase C and adenylate cyclase pathways in rat tail artery.

Journal: Cardiovascular research 20040901

Title: Metabotropic glutamate receptor activation regulates fragile x mental retardation protein and FMR1 mRNA localization differentially in dendrites and at synapses.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20040317

Title: Thyrotropin-releasing hormone increases phospholipase D activity through stimulation of protein kinase C in GH3 cells.

Journal: Endocrine 20040201

Title: Implication of spinal protein kinase C in the suppression of morphine-induced rewarding effect under a neuropathic pain-like state in mice.

Journal: Neuroscience 20040101

Title: Isoform-selectivity of PKC inhibitors acting at the regulatory and catalytic domain of mammalian PKC-alpha, -betaI, -delta, -eta and -zeta.

Journal: Journal of enzyme inhibition and medicinal chemistry 20031201

Title: Adenosine-induced IL-6 expression in pituitary folliculostellate cells is mediated via A2b adenosine receptors coupled to PKC and p38 MAPK.

Journal: British journal of pharmacology 20031001

Title: Arsenite stimulated glucose transport in 3T3-L1 adipocytes involves both Glut4 translocation and p38 MAPK activity.

Journal: European journal of biochemistry 20031001

Title: Functional roles of the rho/rho kinase pathway and protein kinase C in the regulation of cerebrovascular constriction mediated by hemoglobin: relevance to subarachnoid hemorrhage and vasospasm.

Journal: Circulation research 20030418

Title: Control of head morphogenesis in an invertebrate asexually produced larva-like bud ( Cassiopea andromeda; Cnidaria: Scyphozoa).

Journal: Development genes and evolution 20030401

Title: Activation of protein kinase C beta II by the stereo-specific phosphatidylserine receptor is required for phagocytosis of apoptotic thymocytes by resident murine tissue macrophages.

Journal: The Journal of biological chemistry 20020927

Title: Role of protein kinase C in light adaptation of molluscan microvillar photoreceptors.

Journal: The Journal of physiology 20020901

Title: Effects of dexamethasone and protein kinase C inhibitors on the induction of bradykinin B1 mRNA and the bradykinin B1 receptor-mediated contractile response in isolated rat ileum.

Journal: Biochemical pharmacology 20020601

Title: Stimulation of catecholamine biosynthesis via the protein kinase C pathway by endothelin-1 in PC12 rat pheochromocytoma cells.

Journal: Biochemical pharmacology 20020301

Title: Up-regulation of the G(q/11alpha) protein and protein kinase C during the development of sensitization to morphine-induced hyperlocomotion.

Journal: Neuroscience 20020101

Title: Lipoprotein-X stimulates monocyte chemoattractant protein-1 expression in mesangial cells via nuclear factor-kappa B.

Journal: Kidney international 20010801

Title: Modulation of NMDA-mediated excitotoxicity by protein kinase C.

Journal: Journal of neurochemistry 20010801

Title: The polycationic aminoglycosides modulate the vasoconstrictive effects of endothelin: relevance to cerebral vasospasm.

Journal: British journal of pharmacology 20010501

Title: Differential effect of PKC isoform on insulin- and phorbol ester-stimulated glucose uptake mechanism in rat adipocytes.

Journal: IUBMB life 20010501

Title: Differential regulation of microglial NO production by protein kinase C inhibitors.

Journal: Neurochemistry international 20010101

Title: Ro 32-0432, a selective and orally active inhibitor of protein kinase C prevents T-cell activation.

Journal: The Journal of pharmacology and experimental therapeutics 19940201

Title: Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C.

Journal: The Biochemical journal 19930901

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Tags:151342-35-7 Molecular Formula|151342-35-7 MDL|151342-35-7 SMILES|151342-35-7 1H-Pyrrole-2,5-dione, 3-[(8S)-8-[(dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methyl-1H-indol-3-yl)-