Home Fluorides 151555-47-4
151555-47-4,MFCD00923194
Catalog No.:AA001NBW

151555-47-4 | Estra-1,3,5(10)-triene-3,17-diol, 11-[4-[[5-[(4,4,5,5,5-pentafluoropentyl)sulfonyl]pentyl]oxy]phenyl]-, (11β,17β)-

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10mg
2 weeks  
$1,104.00   $773.00
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25mg
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$1,749.00   $1,224.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA001NBW
Chemical Name:
Estra-1,3,5(10)-triene-3,17-diol, 11-[4-[[5-[(4,4,5,5,5-pentafluoropentyl)sulfonyl]pentyl]oxy]phenyl]-, (11β,17β)-
CAS Number:
151555-47-4
Molecular Formula:
C34H43F5O5S
Molecular Weight:
658.7592
MDL Number:
MFCD00923194
SMILES:
Oc1ccc2c(c1)CC[C@@H]1[C@@H]2[C@H](C[C@]2([C@H]1CC[C@@H]2O)C)c1ccc(cc1)OCCCCCS(=O)(=O)CCCC(C(F)(F)F)(F)F
Properties
Computed Properties
 
Complexity:
1070  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
6  
Heavy Atom Count:
45  
Hydrogen Bond Acceptor Count:
10  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
12  
XLogP3:
8  

Literature

Title: Coadministration of nanosystems of short silencing RNAs targeting oestrogen receptor alpha and anti-oestrogen synergistically induces tumour growth inhibition in human breast cancer xenografts.

Journal: Breast cancer research and treatment 20100701

Title: Pure antiestrogen-induced G1-arrest in myeloma cells results from the reduced kinase activity of cyclin D3/CDK6 complexes whereas apoptosis is mediated by endoplasmic reticulum-dependent caspases.

Journal: International journal of cancer 20080501

Title: Definition of functionally important mechanistic differences among selective estrogen receptor down-regulators.

Journal: Cancer research 20071001

Title: Facilitating antidepressant-like actions of estrogens are mediated by 5-HT1A and estrogen receptors in the rat forced swimming test.

Journal: Psychoneuroendocrinology 20060901

Title: Insulin-like growth factor binding protein 2 is a marker for antiestrogen resistant human breast cancer cell lines but is not a major growth regulator.

Journal: Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society 20060801

Title: Improved antitumoral properties of pure antiestrogen RU 58668-loaded liposomes in multiple myeloma.

Journal: The Journal of steroid biochemistry and molecular biology 20060701

Title: Characterization of a human breast cancer cell line, MCF-7/RU58R-1, resistant to the pure antiestrogen RU 58,668.

Journal: Breast cancer research and treatment 20050501

Title: Role of the proteasome in the regulation of estrogen receptor alpha turnover and function in MCF-7 breast carcinoma cells.

Journal: The Journal of steroid biochemistry and molecular biology 20050301

Title: Death-associated protein kinase loss of expression is a new marker for breast cancer prognosis.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20040501

Title: Regulation of estrogen receptor (ER) isoform messenger RNA expression by different ER ligands in female rat pituitary.

Journal: Biology of reproduction 20040301

Title: Pure antiestrogen RU 58668-loaded nanospheres: morphology, cell activity and toxicity studies.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20040201

Title: Mechanisms governing the accumulation of estrogen receptor alpha in MCF-7 breast cancer cells treated with hydroxytamoxifen and related antiestrogens.

Journal: The Journal of steroid biochemistry and molecular biology 20031101

Title: Various phosphorylation pathways, depending on agonist and antagonist binding to endogenous estrogen receptor alpha (ERalpha), differentially affect ERalpha extractability, proteasome-mediated stability, and transcriptional activity in human breast cancer cells.

Journal: Molecular endocrinology (Baltimore, Md.) 20031001

Title: In vitro and in vivo biologic evaluation of long-circulating biodegradable drug carriers loaded with the pure antiestrogen RU 58668.

Journal: International journal of cancer 20030901

Title: Polyester-poly(ethylene glycol) nanoparticles loaded with the pure antiestrogen RU 58668: physicochemical and opsonization properties.

Journal: Pharmaceutical research 20030701

Title: A functional androgen receptor is not sufficient to allow estradiol to protect bone after gonadectomy in estradiol receptor-deficient mice.

Journal: The Journal of clinical investigation 20030501

Title: Dexamethasone blocks antioestrogen- and oxidant-induced death of pituitary tumour cells.

Journal: The Journal of endocrinology 20010501

Title: Inhibition of volume-regulated anion channels in cultured endothelial cells by the anti-oestrogens clomiphene and nafoxidine.

Journal: British journal of pharmacology 20010101

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Tags:151555-47-4 Molecular Formula|151555-47-4 MDL|151555-47-4 SMILES|151555-47-4 Estra-1,3,5(10)-triene-3,17-diol, 11-[4-[[5-[(4,4,5,5,5-pentafluoropentyl)sulfonyl]pentyl]oxy]phenyl]-, (11β,17β)-