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Home Other Building Blocks 1515856-92-4
1515856-92-4,MFCD28166367
Catalog No.:AA00ABJA

1515856-92-4 | XEN445

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$11.00   $8.00
- +
5mg
98%
in stock  
$24.00   $17.00
- +
10mg
98%
in stock  
$35.00   $25.00
- +
25mg
98%
in stock  
$58.00   $41.00
- +
50mg
98%
in stock  
$97.00   $68.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00ABJA
Chemical Name:
XEN445
CAS Number:
1515856-92-4
Molecular Formula:
C18H17F3N2O3
Molecular Weight:
366.3344
MDL Number:
MFCD28166367
SMILES:
OC(=O)c1cc(ccc1N1CCC(C1)OCc1ccccn1)C(F)(F)F
Properties
Computed Properties
 
Complexity:
489  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
26  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
5  
XLogP3:
3  

Downstream Synthesis Route
C10H14N2O 
  115029-23-7   
(S)-2-(3-(pyridin-2-ylmethoxy)pyrrolidin-1-yl)-5-(trifluoromethyl)benzoicacid 

[1]BioorganicandMedicinalChemistry,2013,vol.21,p.7724-7734

Literature

Title: Sun S, et al. Discovery of XEN445: a potent and selective endothelial lipase inhibitor raises plasma HDL-cholesterol concentration in mice. Bioorg Med Chem. 2013 Dec 15;21(24):7724-34.

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SDS
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