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15183-37-6,MFCD00198996
Catalog No.:AA007WQS

15183-37-6 | Estetrol

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
97%
in stock  
$340.00   $238.00
- +
5mg
97%
in stock  
$1,329.00   $930.00
- +
10mg
97%
in stock  
$2,343.00   $1,640.00
- +
25mg
97%
in stock  
$5,200.00   $3,640.00
- +
50mg
97%
in stock  
$9,315.00   $6,520.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA007WQS
Chemical Name:
Estetrol
CAS Number:
15183-37-6
Molecular Formula:
C18H24O4
Molecular Weight:
304.3808
MDL Number:
MFCD00198996
SMILES:
Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1[C@@H](O)[C@H]([C@@H]2O)O)C
Properties
Computed Properties
 
Complexity:
441  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
7  
Heavy Atom Count:
22  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
4  
XLogP3:
1.5  

Literature

Title: Vasorelaxing effects of estetrol in rat arteries.

Journal: The Journal of endocrinology 20121001

Title: Breast epithelial cell proliferation is markedly increased with short-term high levels of endogenous estrogen secondary to controlled ovarian hyperstimulation.

Journal: Breast cancer research and treatment 20120401

Title: Temperature-controlled micro-TLC: a versatile green chemistry and fast analytical tool for separation and preliminary screening of steroids fraction from biological and environmental samples.

Journal: The Journal of steroid biochemistry and molecular biology 20111101

Title: Pharmacological profile of estrogens in oral contraception.

Journal: Minerva ginecologica 20110601

Title: [Estrogen: estrone (E1), estradiol (E2), estriol (E3) and estetrol (E4)].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20100701

Title: Determination of endocrine disrupting compounds using temperature-dependent inclusion chromatography: II. Fast screening of free steroids and related low-molecular-mass compounds fraction in the environmental samples derived from surface waters, treated and untreated sewage waters as well as activated sludge material.

Journal: Journal of chromatography. A 20091030

Title: Determination of endocrine disrupting compounds using temperature-dependent inclusion chromatography: I. Optimization of separation protocol.

Journal: Journal of chromatography. A 20091030

Title: Clinical applications for estetrol.

Journal: The Journal of steroid biochemistry and molecular biology 20090301

Title: Interaction of native alpha-cyclodextrin, beta-cyclodextrin and gamma-cyclodextrin and their hydroxypropyl derivatives with selected organic low molecular mass compounds at elevated and subambient temperature under RP-HPLC conditions.

Journal: Analytical and bioanalytical chemistry 20080801

Title: Estetrol: a unique steroid in human pregnancy.

Journal: The Journal of steroid biochemistry and molecular biology 20080501

Title: Ovulation inhibition by estetrol in an in vivo model.

Journal: Contraception 20080301

Title: Estetrol: a unique steroid in human pregnancy.

Journal: Climacteric : the journal of the International Menopause Society 20080101

Title: Oral bioavailability and bone-sparing effects of estetrol in an osteoporosis model.

Journal: Climacteric : the journal of the International Menopause Society 20080101

Title: Preventive effect of oral estetrol in a menopausal hot flush model.

Journal: Climacteric : the journal of the International Menopause Society 20080101

Title: Estrogenic uterovaginal effects of oral estetrol in the modified Allen-Doisy test.

Journal: Climacteric : the journal of the International Menopause Society 20080101

Title: First human exposure to exogenous single-dose oral estetrol in early postmenopausal women.

Journal: Climacteric : the journal of the International Menopause Society 20080101

Title: Estetrol does not bind sex hormone binding globulin or increase its production by human HepG2 cells.

Journal: Climacteric : the journal of the International Menopause Society 20080101

Title: Estetrol review: profile and potential clinical applications.

Journal: Climacteric : the journal of the International Menopause Society 20080101

Title: A new route of synthesis of estetrol.

Journal: Climacteric : the journal of the International Menopause Society 20080101

Title: In vitro effects of estetrol on receptor binding, drug targets and human liver cell metabolism.

Journal: Climacteric : the journal of the International Menopause Society 20080101

Title: Maternal and fetal estetrol levels during pregnancy.

Journal: Climacteric : the journal of the International Menopause Society 20080101

Title: Characterization of human fetal cord blood steroid profiles in relation to fetal sex and mode of delivery using temperature-dependent inclusion chromatography and principal component analysis (PCA).

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070815

Title: Determination of steroids in human plasma using temperature-dependent inclusion chromatography for metabolomic investigations.

Journal: Journal of chromatography. A 20060203

Title: [Estrogen: estrone (E1), estradiol (E2), estriol (E3) and estetrol (E4)].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20050801

Title: Endogenous estradiol metabolites stimulate the in vitro proliferation of human osteoblastic cells.

Journal: International journal of clinical pharmacology and therapeutics 20030401

Title: Simple chamber for temperature-controlled planar chromatography.

Journal: Journal of chromatography. A 20020920

Title: Valéra MC, et al. Effect of estetrol, a selective nuclear estrogen receptor modulator, in mouse models of arterial and venous thrombosis. Mol Cell Endocrinol. 2018 Dec 5;477:132-139.

Title: Montt-Guevara MM, et al. Estetrol Modulates Endothelial Nitric Oxide Synthesis in Human Endothelial Cells. Front Endocrinol (Lausanne). 2015 Jul 22;6:111.

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