Home Other Building Blocks 152044-54-7
152044-54-7,MFCD02101921
Catalog No.:AA00AQ62

152044-54-7 | Patupilone

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥95%
in stock  
$156.00   $109.00
- +
5mg
≥95%
in stock  
$688.00   $481.00
- +
10mg
≥95%
in stock  
$1,223.00   $856.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00AQ62
Chemical Name:
Patupilone
CAS Number:
152044-54-7
Molecular Formula:
C27H41NO6S
Molecular Weight:
507.6825
MDL Number:
MFCD02101921
SMILES:
O=C1O[C@@H](C[C@@H]2O[C@]2(C)CCC[C@@H]([C@@H]([C@H](C(=O)C([C@H](C1)O)(C)C)C)O)C)/C(=C/c1csc(n1)C)/C
NSC Number:
684363
Properties
Computed Properties
 
Complexity:
816  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
7  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
35  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
2  
XLogP3:
4.2  

Literature

Title: Nerve growth factor alters microtubule targeting agent-induced neurotransmitter release but not MTA-induced neurite retraction in sensory neurons.

Journal: Experimental neurology 20160501

Title: Induction of apoptosis in human ovarian cancer cells by new anticancer compounds, epothilone A and B.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20130201

Title: Randomized, open-label, phase III study comparing patupilone (EPO906) with pegylated liposomal doxorubicin in platinum-refractory or -resistant patients with recurrent epithelial ovarian, primary fallopian tube, or primary peritoneal cancer.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20121101

Title: Epothilone B inhibits migration of glioblastoma cells by inducing microtubule catastrophes and affecting EB1 accumulation at microtubule plus ends.

Journal: Biochemical pharmacology 20120815

Title: Patupilone and ixabepilone: the effect of a point structural change on the exo-endo conformational profile.

Journal: The journal of physical chemistry. B 20120705

Title: Novel physiologically based pharmacokinetic modeling of patupilone for human pharmacokinetic predictions.

Journal: Cancer chemotherapy and pharmacology 20120601

Title: Differential in vitro sensitivity to patupilone versus paclitaxel in uterine and ovarian carcinosarcoma cell lines is linked to tubulin-beta-III expression.

Journal: Gynecologic oncology 20120401

Title: Tubulin binding, protein-bound conformation in solution, and antimitotic cellular profiling of noscapine and its derivatives.

Journal: Journal of medicinal chemistry 20120308

Title: A phase 2 study of patupilone in patients with metastatic castration-resistant prostate cancer previously treated with docetaxel: Canadian Urologic Oncology Group study P07a.

Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20120101

Title: Patupilone (epothilone B) for recurrent glioblastoma: clinical outcome and translational analysis of a single-institution phase I/II trial.

Journal: Oncology 20120101

Title: Collapsin response mediator proteins (CRMPs) are a new class of microtubule-associated protein (MAP) that selectively interacts with assembled microtubules via a taxol-sensitive binding interaction.

Journal: The Journal of biological chemistry 20111202

Title: Pharmacokinetics and antitumor activity of patupilone combined with midazolam or omeprazole in patients with advanced cancer.

Journal: Cancer chemotherapy and pharmacology 20111201

Title: Clinical activity of patupilone in patients with pretreated advanced/metastatic colon cancer: results of a phase I dose escalation trial.

Journal: British journal of cancer 20111122

Title: Regulation of VEGF-expression by patupilone and ionizing radiation in lung adenocarcinoma cells.

Journal: Lung cancer (Amsterdam, Netherlands) 20110901

Title: Epothilone B enhances Class I HLA and HLA-A2 surface molecule expression in ovarian cancer cells.

Journal: Gynecologic oncology 20110901

Title: The microtubule stabilizer patupilone (epothilone B) is a potent radiosensitizer in medulloblastoma cells.

Journal: Neuro-oncology 20110901

Title: A simplified synthesis of novel dictyostatin analogues with in vitro activity against epothilone B-resistant cells and antiangiogenic activity in zebrafish embryos.

Journal: Molecular cancer therapeutics 20110601

Title: Metabolism of tumors under treatment: mapping of metabolites with quantitative bioluminescence.

Journal: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 20110601

Title: Hallmarks of molecular action of microtubule stabilizing agents: effects of epothilone B, ixabepilone, peloruside A, and laulimalide on microtubule conformation.

Journal: The Journal of biological chemistry 20110401

Title: Stereoselective synthesis of 12,13-cyclopropyl-epothilone B and side-chain-modified variants.

Journal: Organic letters 20110318

Title: Epothilones in prostate cancer.

Journal: Urologic oncology 20110101

Title: Evaluation of the mTOR inhibitor, everolimus, in combination with cytotoxic antitumor agents using human tumor models in vitro and in vivo.

Journal: Anti-cancer drugs 20110101

Title: Identification of clinically used drugs that activate pregnane X receptors.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20110101

Title: Patupilone in cancer treatment.

Journal: Expert opinion on investigational drugs 20110101

Title: Effects of patupilone on the pharmacokinetics and pharmacodynamics of warfarin in patients with advanced malignancies: a phase I clinical trial.

Journal: Molecular cancer therapeutics 20110101

Title: Specific β-tubulin isotypes can functionally enhance or diminish epothilone B sensitivity in non-small cell lung cancer cells.

Journal: PloS one 20110101

Title: The epothilone B analogue ixabepilone in patients with advanced hepatobiliary cancers: a trial of the University of Chicago Phase II Consortium.

Journal: Investigational new drugs 20101201

Title: Identifying subsets of metastatic breast cancer patients likely to benefit from treatment with the epothilone B analog ixabepilone.

Journal: American journal of clinical oncology 20101201

Title: Epothilone B enhances surface EpCAM expression in ovarian cancer Hey cells.

Journal: Gynecologic oncology 20101101

Title: Optimizing ixabepilone treatment schedules in patients with advanced or metastatic breast cancer.

Journal: Cancer chemotherapy and pharmacology 20101101

Title: Higher sensitivity to patupilone versus paclitaxel chemotherapy in primary uterine serous papillary carcinoma cell lines with high versus low HER-2/neu expression in vitro.

Journal: Gynecologic oncology 20101001

Title: Phase I trial using patupilone (epothilone B) and concurrent radiotherapy for central nervous system malignancies.

Journal: International journal of radiation oncology, biology, physics 20100715

Title: The interaction between mitotic checkpoint proteins, CENP-E and BubR1, is diminished in epothilone B-resistant A549 cells.

Journal: Cell cycle (Georgetown, Tex.) 20100315

Title: Identifying a resistance determinant for the antimitotic natural products disorazole C1 and A1.

Journal: The Journal of pharmacology and experimental therapeutics 20100301

Title: Microtubule stabilization opposes the (TNF-alpha)-induced loss in the barrier integrity of corneal endothelium.

Journal: Experimental eye research 20091201

Title: Safety and efficacy of patupilone in patients with advanced ovarian, primary fallopian, or primary peritoneal cancer: a phase I, open-label, dose-escalation study.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20090701

Title: Length of mitotic arrest induced by microtubule-stabilizing drugs determines cell death after mitotic exit.

Journal: Molecular cancer therapeutics 20090601

Title: Phase II trial of weekly patupilone in patients with castration-resistant prostate cancer.

Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20090301

Title: Role of the microenvironment for radiosensitization by patupilone.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20090215

Title: Synthesis and biological activities of high affinity taxane-based fluorescent probes.

Journal: Bioorganic & medicinal chemistry letters 20090201

Title: Differential effects of natural product microtubule stabilizers on microtubule assembly: single agent and combination studies with taxol, epothilone B, and discodermolide.

Journal: Chembiochem : a European journal of chemical biology 20090105

Title: Human multidrug resistance protein 7 (ABCC10) is a resistance factor for nucleoside analogues and epothilone B.

Journal: Cancer research 20090101

Title: Comparison of [18F]-tracers in various experimental tumor models by PET imaging and identification of an early response biomarker for the novel microtubule stabilizer patupilone.

Journal: Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging 20090101

Title: Other paradigms: growth rate constants and tumor burden determined using computed tomography data correlate strongly with the overall survival of patients with renal cell carcinoma.

Journal: Cancer journal (Sudbury, Mass.) 20090101

Title: Biotransformation profiling of [(14)C]ixabepilone in human plasma, urine and feces samples using accelerator mass spectrometry (AMS).

Journal: Drug metabolism and pharmacokinetics 20090101

Title: Total synthesis of epothilones B and D: stannane equivalents for beta-keto ester dianions.

Journal: The Journal of organic chemistry 20081219

Title: Molecular mechanisms of patupilone resistance.

Journal: Cancer research 20081215

Title: Pharmacokinetic profile of the microtubule stabilizer patupilone in tumor-bearing rodents and comparison of anti-cancer activity with other MTS in vitro and in vivo.

Journal: Cancer chemotherapy and pharmacology 20081101

Title: Patupilone-induced apoptosis is mediated by mitochondrial reactive oxygen species through Bim relocalization to mitochondria.

Journal: Molecular pharmacology 20081001

Title: A phase I trial of gemcitabine in combination with patupilone in patients with advanced solid tumors.

Journal: Cancer chemotherapy and pharmacology 20080901

Title: Epothilone B induces glioblastoma cell death via survivin down-regulation.

Journal: Experimental oncology 20080901

Title: Epothilones: clinical update and future directions.

Journal: Oncology (Williston Park, N.Y.) 20080415

Title: Epothilones and new analogues of the microtubule modulators in taxane-resistant disease.

Journal: Expert opinion on investigational drugs 20080401

Title: Preclinical investigations with epothilones in breast cancer models.

Journal: Seminars in oncology 20080401

Title: Clinical studies with epothilones for the treatment of metastatic breast cancer.

Journal: Seminars in oncology 20080401

Title: Cell-based and biochemical structure-activity analyses of analogs of the microtubule stabilizer dictyostatin.

Journal: Molecular pharmacology 20080301

Title: Differential responses of mitotic spindle pole formation to microtubule-stabilizing agents epothilones A and B at low concentrations.

Journal: Cell cycle (Georgetown, Tex.) 20080215

Title: [Efficacy and safety of ixabepilone (BMS-247550), a novel epothilone B analogue].

Journal: Bulletin du cancer 20080201

Title: Selective production of epothilone B by heterologous expression of propionyl-CoA synthetase in Sorangium cellulosum.

Journal: Journal of microbiology and biotechnology 20080101

Title: Epothilones induce human colon cancer SW620 cell apoptosis via the tubulin polymerization independent activation of the nuclear factor-kappaB/IkappaB kinase signal pathway.

Journal: Molecular cancer therapeutics 20071001

Title: Mutation and a high-throughput screening method for improving the production of Epothilones of Sorangium.

Journal: Journal of industrial microbiology & biotechnology 20070901

Title: Ixabepilone and the narrow path to developing new cytotoxic drugs.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20070810

Title: Phase II trial of ixabepilone, an epothilone B analog, in patients with metastatic breast cancer previously untreated with taxanes.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20070810

Title: Phase II clinical trial of ixabepilone (BMS-247550), an epothilone B analog, as first-line therapy in patients with metastatic breast cancer previously treated with anthracycline chemotherapy.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20070810

Title: Phase II clinical trial of the epothilone B analog, ixabepilone, in patients with non small-cell lung cancer whose tumors have failed first-line platinum-based chemotherapy.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20070810

Title: Phase II clinical trial of ixabepilone (BMS-247550), an epothilone B analog, in patients with taxane-resistant metastatic breast cancer.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20070810

Title: A phase Ib and pharmacokinetic trial of patupilone combined with carboplatin in patients with advanced cancer.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20070715

Title: Epothilones in prostate cancer: review of clinical experience.

Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20070701

Title: Potential clinical applications of epothilones: a review of phase II studies.

Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20070701

Title: Novel tubulin-targeting agents: anticancer activity and pharmacologic profile of epothilones and related analogues.

Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20070701

Title: Epothilone B inhibits neointimal formation after rat carotid injury through the regulation of cell cycle-related proteins.

Journal: The Journal of pharmacology and experimental therapeutics 20070501

Title: Phase II trial of ixabepilone, an epothilone B analog, given daily for three days every three weeks, in metastatic breast cancer.

Journal: Investigational new drugs 20070201

Title: Cyclostreptin binds covalently to microtubule pores and lumenal taxoid binding sites.

Journal: Nature chemical biology 20070201

Title: Combination of sublethal concentrations of epidermal growth factor receptor inhibitor and microtubule stabilizer induces apoptosis of glioblastoma cells.

Journal: Molecular cancer therapeutics 20070201

Title: Microtubule-targeting agents inhibit angiogenesis at subtoxic concentrations, a process associated with inhibition of Rac1 and Cdc42 activity and changes in the endothelial cytoskeleton.

Journal: Molecular cancer therapeutics 20060901

Title: Epothilones in the treatment of cancer.

Journal: Expert opinion on investigational drugs 20060601

Title: Peripheral neuropathy induced by microtubule-stabilizing agents.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20060401

Title: Paclitaxel-resistant cells have a mutation in the paclitaxel-binding region of beta-tubulin (Asp26Glu) and less stable microtubules.

Journal: Molecular cancer therapeutics 20060201

Title: A reassignment of (-)-mycothiazole and the isolation of a related diol.

Journal: Journal of natural products 20060101

Title: Effects of patupilone (epothilone B; EPO906), a novel chemotherapeutic agent, in hepatocellular carcinoma: an in vitro study.

Journal: Oncology 20060101

Title: Current state of the art of new tubulin inhibitors in the clinic.

Journal: Current clinical pharmacology 20060101

Title: Phase I dose-finding study of weekly single-agent patupilone in patients with advanced solid tumors.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20051220

Title: Patupilone (epothilone B, EPO906) inhibits growth and metastasis of experimental prostate tumors in vivo.

Journal: The Prostate 20051101

Title: Patupilone induced vascular disruption in orthotopic rodent tumor models detected by magnetic resonance imaging and interstitial fluid pressure.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20051101

Title: In vivo evaluation of ixabepilone (BMS247550), a novel epothilone B derivative, against pediatric cancer models.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20051001

Title: Both microtubule-stabilizing and microtubule-destabilizing drugs inhibit hypoxia-inducible factor-1alpha accumulation and activity by disrupting microtubule function.

Journal: Cancer research 20051001

Title: Epothilones and the next generation of phase III trials for prostate cancer.

Journal: BJU international 20050801

Title: A highly epothilone B-resistant A549 cell line with mutations in tubulin that confer drug dependence.

Journal: Molecular cancer therapeutics 20050601

Title: Patupilone (epothilone B, EPO906) and imatinib (STI571, Glivec) in combination display enhanced antitumour activity in vivo against experimental rat C6 glioma.

Journal: Cancer chemotherapy and pharmacology 20050401

Title: Much anticipated--the bioactive conformation of epothilone and its binding to tubulin.

Journal: Angewandte Chemie (International ed. in English) 20050218

Title: Patupilone acts as radiosensitizing agent in multidrug-resistant cancer cells in vitro and in vivo.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20050215

Title: Patupilone (epothilone B) inhibits growth and survival of multiple myeloma cells in vitro and in vivo.

Journal: Blood 20050101

Title: Total syntheses of epothilones B and d.

Journal: The Journal of organic chemistry 20041224

Title: EpoK, a cytochrome P450 involved in biosynthesis of the anticancer agents epothilones A and B. Substrate-mediated rescue of a P450 enzyme.

Journal: Biochemistry 20041123

Title: Hybrid nonribosomal peptide-polyketide interfaces in epothilone biosynthesis: minimal requirements at N and C termini of EpoB for elongation.

Journal: Chemistry & biology 20041101

Title: Tumor necrosis factor-alpha related gene response to Epothilone B in ovarian cancer.

Journal: Gynecologic oncology 20040401

Title: [Structure-activity relationship analysis].

Journal: Gan to kagaku ryoho. Cancer & chemotherapy 20040401

Title: Phase I clinical and pharmacokinetic study of BMS-247550, a novel derivative of epothilone B, in solid tumors.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20040215

Title: What makes epothilones stick?

Journal: Chemistry & biology 20040201

Title: Cathepsin B mediates caspase-independent cell death induced by microtubule stabilizing agents in non-small cell lung cancer cells.

Journal: Cancer research 20040101

Title: Lessons learned from macrolide synthesis.

Journal: Chemical record (New York, N.Y.) 20040101

Title: Suppression of microtubule dynamics by discodermolide by a novel mechanism is associated with mitotic arrest and inhibition of tumor cell proliferation.

Journal: Molecular cancer therapeutics 20031201

Title: Gene expression and mitotic exit induced by microtubule-stabilizing drugs.

Journal: Cancer research 20031115

Title: Crystal structures of epothilone D-bound, epothilone B-bound, and substrate-free forms of cytochrome P450epoK.

Journal: The Journal of biological chemistry 20031107

Title: Pilot study of epothilone B analog (BMS-247550) and estramustine phosphate in patients with progressive metastatic prostate cancer following castration.

Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20031001

Title: Histone deacetylase inhibitor LAQ824 down-regulates Her-2 and sensitizes human breast cancer cells to trastuzumab, taxotere, gemcitabine, and epothilone B.

Journal: Molecular cancer therapeutics 20031001

Title: Potential radiation-sensitizing effect of semisynthetic epothilone B in human lung cancer cells.

Journal: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 20030901

Title: STI571 enhances the therapeutic index of epothilone B by a tumor-selective increase of drug uptake.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20030901

Title: Highlights from the 39th Annual meeting of the American Society of Clinical Oncology Chicago, Illinois.

Journal: Clinical prostate cancer 20030901

Title: Polyketide-nonribosomal peptide epothilone antitumor agents: the EpoA, B, C subunits.

Journal: Journal of industrial microbiology & biotechnology 20030801

Title: Total synthesis of the microtubule stabilizing antitumor agent laulimalide and some nonnatural analogues: the power of Sharpless' asymmetric epoxidation.

Journal: The Journal of organic chemistry 20030418

Title: Epothilone B and its analogs - a new family of anticancer agents.

Journal: Mini reviews in medicinal chemistry 20030301

Title: Flavopiridol down-regulates antiapoptotic proteins and sensitizes human breast cancer cells to epothilone B-induced apoptosis.

Journal: Cancer research 20030101

Title: Protracted low-dose effects on human endothelial cell proliferation and survival in vitro reveal a selective antiangiogenic window for various chemotherapeutic drugs.

Journal: Cancer research 20021201

Title: Late activation of apoptotic pathways plays a negligible role in mediating the cytotoxic effects of discodermolide and epothilone B in non-small cell lung cancer cells.

Journal: Cancer research 20020715

Title: Ectopic overexpression of second mitochondria-derived activator of caspases (Smac/DIABLO) or cotreatment with N-terminus of Smac/DIABLO peptide potentiates epothilone B derivative-(BMS 247550) and Apo-2L/TRAIL-induced apoptosis.

Journal: Blood 20020501

Title: Enzymatic assembly of epothilones: the EpoC subunit and reconstitution of the EpoA-ACP/B/C polyketide and nonribosomal peptide interfaces.

Journal: Biochemistry 20020430

Title: Differential mitotic responses to microtubule-stabilizing and -destabilizing drugs.

Journal: Cancer research 20020401

Title: Studies on the biosynthesis of epothilones: hydroxylation of Epo A and B to epothilones E and F.

Journal: The Journal of antibiotics 20020101

Title: Gene expression profiling of epothilone A-resistant cells.

Journal: Novartis Foundation symposium 20020101

Title: Epothilones: a novel class of non-taxane microtubule-stabilizing agents.

Journal: Current pharmaceutical design 20020101

Title: Total synthesis of epothilone B.

Journal: Organic letters 20011115

Title: Stereoselective syntheses of epothilones A and B via nitrile oxide cycloadditions and related studies.

Journal: The Journal of organic chemistry 20010921

Title: The epothilones, eleutherobins, and related types of molecules.

Journal: Current pharmaceutical design 20010901

Title: Epothilone biosynthesis: assembly of the methylthiazolylcarboxy starter unit on the EpoB subunit.

Journal: Chemistry & biology 20010901

Title: Tubulins in the primate retina: evidence that xanthophylls may be endogenous ligands for the paclitaxel-binding site.

Journal: Bioorganic & medicinal chemistry 20010801

Title: Total synthesis of epothilones B and D.

Journal: Organic letters 20010712

Title: Microtubule structure at improved resolution.

Journal: Biochemistry 20010710

Title: New natural epothilones from Sorangium cellulosum, strains So ce90/B2 and So ce90/D13: isolation, structure elucidation, and SAR studies.

Journal: Journal of natural products 20010701

Title: On the interactivity of complex synthesis and tumor pharmacology in the drug discovery process: total synthesis and comparative in vivo evaluations of the 15-aza epothilones.

Journal: The Journal of organic chemistry 20010615

Title: Total synthesis of epothilone B, epothilone D, and cis- and trans-9,10-dehydroepothilone D.

Journal: Journal of the American Chemical Society 20010613

Title: Treatment with inhibitors of caspases, that are substrates of drug transporters, selectively permits chemotherapy-induced apoptosis in multidrug-resistant cells but protects normal cells.

Journal: Leukemia 20010601

Title: The 12,13-diol cyclization approach for a truly stereocontrolled total synthesis of epothilone B and the synthesis of a conformationally restrained analogue.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20010518

Title: BMS-247550: a novel epothilone analog with a mode of action similar to paclitaxel but possessing superior antitumor efficacy.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20010501

Title: Stereoselective syntheses of epothilones A and B via directed nitrile oxide cycloaddition.

Journal: Journal of the American Chemical Society 20010418

Title: Catalytic antibody route to the naturally occurring epothilones: total synthesis of epothilones A-F.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20010417

Title: Studies on the biosynthesis of epothilones: the PKS and Epothilone C/D monooxygenase.

Journal: The Journal of antibiotics 20010201

Title: In vivo metabolism of epothilone B in tumor-bearing nude mice: identification of three new epothilone B metabolites by capillary high-pressure liquid chromatography/mass spectrometry/tandem mass spectrometry.

Journal: Rapid communications in mass spectrometry : RCM 20010101

Title: Regueiro-Ren A, et al. Synthesis and biological activity of novel epothilone aziridines. Org Lett. 2001 Aug 23;3(17):2693-6.

Title: Pagano A, et al. Epothilone B inhibits migration of glioblastoma cells by inducing microtubule catastrophes and affecting EB1 accumulation at microtubule plus ends. Biochem Pharmacol. 2012 Aug 15;84(4):432-43.

Title: Oehler C, et al. The microtubule stabilizer patupilone (epothilone B) is a potent radiosensitizer in medulloblastoma cells. Neuro Oncol. 2011 Sep;13(9):1000-10.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Tags:152044-54-7 Molecular Formula|152044-54-7 MDL|152044-54-7 SMILES|152044-54-7 Patupilone