Home Other Building Blocks 152918-26-8
152918-26-8,MFCD02094625
Catalog No.:AA00ABK0

152918-26-8 | Ab-meca

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1mg
≥98%
in stock  
$105.00   $73.00
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5mg
≥98%
in stock  
$463.00   $324.00
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10mg
≥98%
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$822.00   $575.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00ABK0
Chemical Name:
Ab-meca
CAS Number:
152918-26-8
Molecular Formula:
C18H21N7O4
Molecular Weight:
399.4038
MDL Number:
MFCD02094625
SMILES:
CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1ccc(cc1)N
Properties
Properties
 
Form:
Solid  
Storage:
-20 ℃;  

Computed Properties
 
Complexity:
576  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
4  
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
9  
Hydrogen Bond Donor Count:
5  
Rotatable Bond Count:
5  
XLogP3:
-0.4  

Literature

Title: Pharmacologic characterization of novel adenosine A2A receptor agonists in equine neutrophils.

Journal: American journal of veterinary research 20070901

Title: Characterization of the potency, selectivity, and pharmacokinetic profile for six adenosine A2A receptor antagonists.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20070401

Title: Characterization of adenosine receptors in the human bladder carcinoma T24 cell line.

Journal: European journal of pharmacology 20060424

Title: Generation of adenosine A3 receptor functionally humanized mice for the evaluation of the human antagonists.

Journal: Biochemical pharmacology 20060112

Title: 2-(Benzimidazol-2-yl)quinoxalines: a novel class of selective antagonists at human A(1) and A(3) adenosine receptors designed by 3D database searching.

Journal: Journal of medicinal chemistry 20051229

Title: Human adenosine A(3) receptor leads to intracellular Ca(2+) mobilization but is insufficient to activate the signaling pathway via phosphoinositide 3-kinase gamma in mice.

Journal: Biochemical pharmacology 20051115

Title: Synthesis and structure-activity relationships of 4-cycloalkylamino-1, 2, 4-triazolo[4, 3-a]quinoxalin-1- one derivatives as A1 and A3 adenosine receptor antagonists.

Journal: Archiv der Pharmazie 20040101

Title: A3 adenosine receptor agonist IB-MECA reduces myocardial ischemia-reperfusion injury in dogs.

Journal: American journal of physiology. Heart and circulatory physiology 20030801

Title: Differential allosteric modulation by amiloride analogues of agonist and antagonist binding at A(1) and A(3) adenosine receptors.

Journal: Biochemical pharmacology 20030215

Title: Pharmacological analysis of calcium responses mediated by the human A3 adenosine receptor in monocyte-derived dendritic cells and recombinant cells.

Journal: Molecular pharmacology 20030201

Title: Gene dosage-dependent effects of cardiac-specific overexpression of the A3 adenosine receptor.

Journal: Circulation research 20020726

Title: Selective allosteric enhancement of agonist binding and function at human A3 adenosine receptors by a series of imidazoquinoline derivatives.

Journal: Molecular pharmacology 20020701

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry 20020419

Title: Allosteric modulation of A(3) adenosine receptors by a series of 3-(2-pyridinyl)isoquinoline derivatives.

Journal: Molecular pharmacology 20011101

Title: [(3)H]MRE 3008F20: a novel antagonist radioligand for the pharmacological and biochemical characterization of human A(3) adenosine receptors.

Journal: Molecular pharmacology 20000501

Title: Structure-activity relationships and molecular modeling of 3, 5-diacyl-2,4-dialkylpyridine derivatives as selective A3 adenosine receptor antagonists.

Journal: Journal of medicinal chemistry 19980813

Title: Comparative pharmacology of human adenosine receptor subtypes - characterization of stably transfected receptors in CHO cells.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 19980101

Title: Pharmacological characterization of novel A3 adenosine receptor-selective antagonists.

Journal: Neuropharmacology 19970901

Title: Derivatives of the triazoloquinazoline adenosine antagonist (CGS15943) are selective for the human A3 receptor subtype.

Journal: Journal of medicinal chemistry 19961011

Title: Shearman LP, et al. 25I4-aminobenzyl-5'-N-methylcarboxamidoadenosine (125I)AB-MECA) labels multiple adenosine receptorsubtypes in rat brain. Brain Res. 1997 Jan 16;745(1-2):10-20.

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