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153212-75-0,MFCD03411966
Catalog No.:AA007Y5F

153212-75-0 | 6α-Hydroxy Paclitaxel

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1mg
≥95%
in stock  
$486.00   $340.00
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5mg
≥95%
in stock  
$2,242.00   $1,569.00
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA007Y5F
Chemical Name:
6α-Hydroxy Paclitaxel
CAS Number:
153212-75-0
Molecular Formula:
C47H51NO15
Molecular Weight:
869.9055
MDL Number:
MFCD03411966
SMILES:
CC(=O)O[C@H]1C(=O)[C@]2(C)[C@@H](O)[C@H](O)[C@@H]3[C@]([C@H]2[C@@H]([C@]2(C(C1=C(C)[C@@H](OC(=O)[C@@H]([C@H](c1ccccc1)NC(=O)c1ccccc1)O)C2)(C)C)O)OC(=O)c1ccccc1)(CO3)OC(=O)C
Properties
Computed Properties
 
Complexity:
1830  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
12  
Heavy Atom Count:
63  
Hydrogen Bond Acceptor Count:
15  
Hydrogen Bond Donor Count:
5  
Rotatable Bond Count:
14  
XLogP3:
1.5  

Literature

Title: Inhibitory Effects of Danshen components on CYP2C8 and CYP2J2.

Journal: Chemico-biological interactions 20180601

Title: Quantitation of paclitaxel and its two major metabolites using a liquid chromatography-electrospray ionization tandem mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20110715

Title: Effect of commonly used organic solvents on the kinetics of cytochrome P450 2B6- and 2C8-dependent activity in human liver microsomes.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20071101

Title: Measurement of paclitaxel and its metabolites in human plasma using liquid chromatography/ion trap mass spectrometry with a sonic spray ionization interface.

Journal: Rapid communications in mass spectrometry : RCM 20060101

Title: Comparison of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) as inhibitors of cytochrome P450 2C8.

Journal: Basic & clinical pharmacology & toxicology 20050801

Title: Metabolism of paclitaxel in mice.

Journal: Anti-cancer drugs 20030301

Title: Monolithic silica rod liquid chromatography with ultraviolet or fluorescence detection for metabolite analysis of cytochrome P450 marker reactions.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20021125

Title: The P-glycoprotein antagonist PSC 833 increases the plasma concentrations of 6alpha-hydroxypaclitaxel, a major metabolite of paclitaxel.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20010601

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Tags:153212-75-0 Molecular Formula|153212-75-0 MDL|153212-75-0 SMILES|153212-75-0 6α-Hydroxy Paclitaxel