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153436-38-5,MFCD00923984
Catalog No.:AA00B0S0

153436-38-5 | GAVESTINEL

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Purity
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Price(USD)
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1mg
≥98%
in stock  
$53.00   $37.00
- +
5mg
≥98%
in stock  
$155.00   $108.00
- +
10mg
≥98%
in stock  
$255.00   $178.00
- +
50mg
99%
in stock  
$883.00   $618.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00B0S0
Chemical Name:
GAVESTINEL
CAS Number:
153436-38-5
Molecular Formula:
C18H11Cl2N2NaO3
Molecular Weight:
397.1873
MDL Number:
MFCD00923984
SMILES:
O=C(Nc1ccccc1)/C=C/c1c([nH]c2c1c(Cl)cc(c2)Cl)C(=O)[O-].[Na+]
Properties
Computed Properties
 
Complexity:
543  
Covalently-Bonded Unit Count:
2  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
26  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
4  

Literature

Title: Discordant behavioral effects of psychotomimetic drugs in mice with altered NMDA receptor function.

Journal: Psychopharmacology 20110101

Title: Competitive inhibition at the glycine site of the N-methyl-D-aspartate receptor mediates xenon neuroprotection against hypoxia-ischemia.

Journal: Anesthesiology 20100301

Title: Clinical diagnosis of lacunar stroke in the first 6 hours after symptom onset: analysis of data from the glycine antagonist in neuroprotection (GAIN) Americas trial.

Journal: Stroke 20071001

Title: Sex as a predictor of outcomes in patients treated with thrombolysis for acute stroke.

Journal: Neurology 20070313

Title: Effect of the Glycine Antagonist Gavestinel on cerebral infarcts in acute stroke patients, a randomized placebo-controlled trial: The GAIN MRI Substudy.

Journal: Cerebrovascular diseases (Basel, Switzerland) 20060101

Title: Xenon and hypothermia combine to provide neuroprotection from neonatal asphyxia.

Journal: Annals of neurology 20050801

Title: Gavestinel does not improve outcome after acute intracerebral hemorrhage: an analysis from the GAIN International and GAIN Americas studies.

Journal: Stroke 20050501

Title: CoMFA, synthesis, and pharmacological evaluation of (E)-3-(2-carboxy-2-arylvinyl)-4,6-dichloro-1H-indole-2-carboxylic acids: 3-[2-(3-aminophenyl)-2-carboxyvinyl]-4,6-dichloro-1H-indole-2-carboxylic acid, a potent selective glycine-site NMDA receptor antagonist.

Journal: Journal of medicinal chemistry 20050224

Title: Poststroke neurological improvement within 7 days is associated with subsequent deterioration.

Journal: Stroke 20040901

Title: Health care resource use after acute stroke in the Glycine Antagonist in Neuroprotection (GAIN) Americas trial.

Journal: Stroke 20040601

Title: The rise and fall of NMDA antagonists for ischemic stroke.

Journal: Current molecular medicine 20040301

Title: Effect of blood pressure during the acute period of ischemic stroke on stroke outcome: a tertiary analysis of the GAIN International Trial.

Journal: Stroke 20031001

Title: Pharmacokinetics, metabolism and excretion of the glycine antagonist GV150526A in rat and dog.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20030401

Title: Stroke Impact Scale-16: A brief assessment of physical function.

Journal: Neurology 20030128

Title: Health care resource use and stroke outcome. Multinational comparisons within the GAIN International trial.

Journal: International journal of technology assessment in health care 20030101

Title: The selective glycine antagonist gavestinel lacks phencyclidine-like behavioral effects.

Journal: Behavioural pharmacology 20021101

Title: Physicochemical study of the solid forms of a new drug.

Journal: Journal of pharmaceutical sciences 20011201

Title: Synthesis and pharmacological characterisation of a conformationally restrained series of indole-2-carboxylates as in vivo potent glycine antagonists.

Journal: Farmaco (Societa chimica italiana : 1989) 20011001

Title: The neuroprotective activity of the glycine receptor antagonist GV150526: an in vivo study by magnetic resonance imaging.

Journal: European journal of pharmacology 20010511

Title: Glycine antagonist in neuroprotection for patients with acute stroke: GAIN Americas: a randomized controlled trial.

Journal: JAMA 20010404

Title: Neuroprotection in acute ischemic stroke.

Journal: JAMA 20010404

Title: Allosteric modulation of [3H]-CGP39653 binding through the glycine site of the NMDA receptor: further studies in rat and human brain.

Journal: British journal of pharmacology 20010401

Title: Glycine antagonist (GV150526) in acute stroke: a multicentre, double-blind placebo-controlled phase II trial.

Journal: Cerebrovascular diseases (Basel, Switzerland) 20010101

Title: Characterization of the binding of two novel glycine site antagonists to cloned NMDA receptors: evidence for two pharmacological classes of antagonists.

Journal: British journal of pharmacology 20000501

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