153504-70-2,MFCD01759988
Catalog No.:AA00ABGP

153504-70-2 | Cevimelinehydrochloride

Pack Size
Purity
Availability
Price(USD)
Quantity
  
2mg
1 week  
$98.00   $68.00
- +
5mg
1 week  
$123.00   $86.00
- +
10mg
1 week  
$168.00   $118.00
- +
25mg
1 week  
$259.00   $181.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA00ABGP
Chemical Name:
Cevimelinehydrochloride
CAS Number:
153504-70-2
Molecular Formula:
C20H38Cl2N2O3S2
Molecular Weight:
489.5633
MDL Number:
MFCD01759988
SMILES:
CC1SCC2(O1)CN1CCC2CC1.CC1SCC2(O1)CN1CCC2CC1.O.Cl.Cl
Properties
Computed Properties
 
Complexity:
215  
Covalently-Bonded Unit Count:
5  
Defined Atom Stereocenter Count:
2  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
3  
Isotope Atom Count:
0  
Rotatable Bond Count:
0  
Undefined Atom Stereocenter Count:
2  
Undefined Bond Stereocenter Count:
0  

Literature

Title: Effectiveness of cevimeline to improve oral health in patients with postradiation xerostomia.

Journal: Head & neck 20120801

Title: Distinct effects of cevimeline and pilocarpine on salivary mechanisms, cardiovascular response and thirst sensation in rats.

Journal: Archives of oral biology 20120401

Title: Treatment of Sjögren's syndrome-associated dry eye an evidence-based review.

Journal: Ophthalmology 20110701

Title: Abnormal subcellular localization of AQP5 and downregulated AQP5 protein in parotid glands of streptozotocin-induced diabetic rats.

Journal: Biochimica et biophysica acta 20110501

Title: Cevimeline-induced monophasic salivation from the mouse submandibular gland: decreased Na+ content in saliva results from specific and early activation of Na+/H+ exchange.

Journal: The Journal of pharmacology and experimental therapeutics 20110401

Title: Cevimeline (Evoxac ®) overdose.

Journal: Journal of medical toxicology : official journal of the American College of Medical Toxicology 20110301

Title: New epitopes and function of anti-M3 muscarinic acetylcholine receptor antibodies in patients with Sjögren's syndrome.

Journal: Clinical and experimental immunology 20101001

Title: The relationship between the drug concentration profiles in plasma and the drug doses in the colon.

Journal: Chemical & pharmaceutical bulletin 20101001

Title: Dosage form design and in vitro/in vivo evaluation of cevimeline extended-release tablet formulations.

Journal: International journal of pharmaceutics 20100104

Title: Comparison of the effects of pilocarpine and cevimeline on salivary flow.

Journal: International journal of dental hygiene 20090501

Title: Identification of aquaporin-5 and lipid rafts in human resting saliva and their release into cevimeline-stimulated saliva.

Journal: Biochimica et biophysica acta 20090101

Title: Sjögren's syndrome patients presenting with hypergammaglobulinemia are relatively unresponsive to cevimeline treatment.

Journal: Modern rheumatology 20090101

Title: Cevimeline enhances the excitability of rat superior salivatory neurons.

Journal: The journal of medical investigation : JMI 20090101

Title: Correlation between salivary secretion and salivary AQP5 levels in health and disease.

Journal: The journal of medical investigation : JMI 20090101

Title: Effects of pilocarpine and cevimeline on Ca2+ mobilization in rat parotid acini and ducts.

Journal: The journal of medical investigation : JMI 20090101

Title: Effects of cevimeline on the immunolocalization of aquaporin-5 and the ultrastructure of salivary glands in Sjögren's syndrome model mice.

Journal: The Kurume medical journal 20090101

Title: Parotid irrigation and cevimeline gargle for treatment of xerostomia in Sjögren's syndrome.

Journal: The Journal of rheumatology 20081101

Title: Degradation of submandibular gland AQP5 by parasympathetic denervation of chorda tympani and its recovery by cevimeline, an M3 muscarinic receptor agonist.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20080701

Title: The efficacy of cevimeline hydrochloride in the treatment of xerostomia in Sjögren's syndrome in southern Chinese patients: a randomised double-blind, placebo-controlled crossover study.

Journal: Clinical rheumatology 20080401

Title: Cevimeline.

Journal: Drugs 20080101

Title: Open-label, long-term safety study of cevimeline in the treatment of postirradiation xerostomia.

Journal: International journal of radiation oncology, biology, physics 20071201

Title: Xerostomia: causes and treatment.

Journal: The Consultant pharmacist : the journal of the American Society of Consultant Pharmacists 20071201

Title: Effect of a muscarinic M3 receptor agonist on gastric motility.

Journal: Journal of gastroenterology and hepatology 20071101

Title: Efficacy prediction of cevimeline in patients with Sjögren's syndrome.

Journal: Clinical rheumatology 20070801

Title: Cevimeline for the treatment of postirradiation xerostomia in patients with head and neck cancer.

Journal: International journal of radiation oncology, biology, physics 20070715

Title: Effect of cevimeline on radiation-induced salivary gland dysfunction and AQP5 in submandibular gland in mice.

Journal: The Bulletin of Tokyo Dental College 20070501

Title: Salivary dysfunction associated with systemic diseases: systematic review and clinical management recommendations.

Journal: Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 20070301

Title: [Revision of the recommendations of the Commission on Pharmacotherapy of the German Society for Rheumatology. Recommendations for supportive therapy for Sjögren's syndrome].

Journal: Zeitschrift fur Rheumatologie 20070201

Title: Effects of cevimeline on salivation and thirst in conscious rats.

Journal: Archives of oral biology 20070101

Title: Unraveling the mysteries of saliva: its importance in maintaining oral health. Transcript of a lecture presented on August 6 at the 2006 AGD Annual Meeting & Exposition.

Journal: General dentistry 20070101

Title: The therapy of Sjogren's syndrome: a review.

Journal: La Clinica terapeutica 20070101

Title: Cevimeline reduced mouth dryness and increased salivary flow in patients with xerostomia complicating chronic graft-versus-host disease.

Journal: Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 20060701

Title: New approaches to preventing xerostomia.

Journal: The journal of supportive oncology 20060201

Title: Cevimeline hydrochloride improved cholinergic dysfunction in a patient with pure autonomic failure.

Journal: Journal of neurology 20060101

Title: Assessment of the use of sialogogues in the clinical management of patients with xerostomia.

Journal: Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry 20060101

Title: Management of xerostomia related to radiotherapy for head and neck cancer.

Journal: Oncology (Williston Park, N.Y.) 20051201

Title: Identification of AQP5 in lipid rafts and its translocation to apical membranes by activation of M3 mAChRs in interlobular ducts of rat parotid gland.

Journal: American journal of physiology. Cell physiology 20051101

Title: Idiopathic CD4+ lymphocytopenia and Sjogren syndrome.

Journal: Archives of ophthalmology (Chicago, Ill. : 1960) 20050701

Title: Effect of cevimeline on salivary components in patients with Sjögren syndrome.

Journal: Pharmacology 20050501

Title: Salivary hypofunction and xerostomia: diagnosis and treatment.

Journal: Dental clinics of North America 20050401

Title: Dentistry. Implications and management of xerostomia in the HIV patient.

Journal: HIV clinician 20050101

Title: Dentistry. Clinic assesses effect of medication on dry mouth syndrome.

Journal: HIV clinician 20050101

Title: Xerostomia secondary to Sjögren's syndrome in the elderly: recognition and management.

Journal: Drugs & aging 20050101

Title: [Clinical significance of cevimeline hydrochloride in the treatment of dry mouth in patients with Sjögren's syndrome].

Journal: Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology 20041001

Title: Therapeutic effect of cevimeline on dry eye in patients with Sjögren's syndrome: a randomized, double-blind clinical study.

Journal: American journal of ophthalmology 20040701

Title: [Future therapy strategies for salivary gland impairment].

Journal: Refu'at ha-peh veha-shinayim (1993) 20040701

Title: Cevimeline gargle for the treatment of xerostomia in patients with Sjögren's syndrome.

Journal: Annals of the rheumatic diseases 20040601

Title: [The effectiveness of cevimeline hydrochloride on dry cough in Sjögren's syndrome].

Journal: Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology 20040401

Title: Radiation-induced xerostomia: how dry is your patient?

Journal: Clinical journal of oncology nursing 20040201

Title: Ligand-selective signaling and high-content screening for GPCR drugs.

Journal: Drug discovery today 20031215

Title: Reduction in distractibility with AF102B and THA in the macaque.

Journal: Pharmacology, biochemistry, and behavior 20030901

Title: Age-related decreases in the response of aquaporin-5 to acetylcholine in rat parotid glands.

Journal: Journal of dental research 20030601

Title: Current therapies for xerostomia and salivary gland hypofunction associated with cancer therapies.

Journal: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20030401

Title: Effect of SNI-2011 on amylase secretion from parotid tissue in rats and in neuronal nitric oxide synthase knockout mice.

Journal: European journal of pharmacology 20030319

Title: Pharmacokinetics and metabolism of the novel muscarinic receptor agonist SNI-2011 in rats and dogs.

Journal: Arzneimittel-Forschung 20030101

Title: Pharmacokinetics and metabolism of radiolabelled SNI-2011, a novel muscarinic receptor agonist, in healthy volunteers. Comprehensive understanding of absorption, metabolism and excretion using radiolabelled SNI-2011.

Journal: Arzneimittel-Forschung 20030101

Title: Effects of pilocarpine hydrochloride and cevimeline on submandibular/sublingual salivation in rat xerostomia model produced by X-ray irradiation.

Journal: Arzneimittel-Forschung 20030101

Title: M1 muscarinic agonists can modulate some of the hallmarks in Alzheimer's disease: implications in future therapy.

Journal: Journal of molecular neuroscience : MN 20030101

Title: [Cevimeline hydrochloride hydrate (Saligren capsule 30 mg): a review of its pharmacological profiles and clinical potential in xerostomia].

Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20021001

Title: Cevimeline for the treatment of xerostomia in patients with Sjögren syndrome: a randomized trial.

Journal: Archives of internal medicine 20020610

Title: Assessing salivary gland hypofunction--Part two.

Journal: Practical procedures & aesthetic dentistry : PPAD 20020401

Title: A double-blind, randomized, placebo-controlled study of cevimeline in Sjögren's syndrome patients with xerostomia and keratoconjunctivitis sicca.

Journal: Arthritis and rheumatism 20020301

Title: General pharmacological profile of the novel muscarinic receptor agonist SNI-2011, a drug for xerostomia in Sjögren's syndrome. 1st communication: effects on general behavior and central nervous system.

Journal: Arzneimittel-Forschung 20020101

Title: General pharmacological profile of the novel muscarinic receptor agonist SNI-2011, a drug for xerostomia in Sjögren's syndrome. 2nd communication: effects on somatic nervous system and on autonomic nervous system and smooth muscle.

Journal: Arzneimittel-Forschung 20020101

Title: General pharmacological profile of the novel muscarinic receptor agonist SNI-2011, a drug for xerostomia in Sjögren's syndrome. 3rd communication: effects on respiratory and cardiovascular systems.

Journal: Arzneimittel-Forschung 20020101

Title: General pharmacological profile of the novel muscarinic receptor agonist SNI-2011, a drug for xerostomia in Sjögren's syndrome. 4th communication: Effects on gastrointestinal, urinary and reproductive systems and other effects.

Journal: Arzneimittel-Forschung 20020101

Title: Use of cevimeline, a muscarinic M1 and M3 agonist, in the treatment of Sjögren's syndrome.

Journal: Advances in experimental medicine and biology 20020101

Title: Use of muscarinic agonists in the treatment of Sjögren's syndrome.

Journal: Clinical immunology (Orlando, Fla.) 20011201

Title: Identification of human drug-metabolizing enzymes involved in the metabolism of SNI-2011.

Journal: Biological & pharmaceutical bulletin 20011101

Title: Salivary enhancement: current status and future therapies.

Journal: Journal of dental education 20011001

Title: Reduction of cerebrospinal fluid amyloid beta after systemic administration of M1 muscarinic agonists.

Journal: Brain research 20010629

Title: A new medication for treatment of dry mouth in Sjögren's syndrome.

Journal: Texas dental journal 20010401

Title: New drug approvals in 2000.

Journal: General dentistry 20010101

Title: AF102B, a muscarinic M1 receptor agonist, mimics some effects of acetylcholine on neurons of rat hippocampus slices.

Journal: European journal of pharmacology 19920910

Title: Central muscarinic activities of an M1-selective agonist: preferential effect on reversal of amnesia.

Journal: Brain research 19900115

Title: Amelioration of experimental amnesia (passive avoidance failure) in rodents by the selective M1 agonist AF102B.

Journal: Japanese journal of pharmacology 19881201

Title: Ono K, et al. Distinct effects of cevimeline and pilocarpine on salivary mechanisms, cardiovascular response and thirst sensation in rats.Arch Oral Biol. 2012 Apr;57(4):421-8. Epub 2011 Nov 17.

Title: Witsell DL, et al. Effectiveness of cevimeline to improve oral health in patients with postradiation xerostomia.Head Neck. 2012 Aug;34(8):1136-42. doi: 10.1002/hed.21894. Epub 2012 Jan 9.

Title: Kondo Y, et al.Cevimeline-induced monophasic salivation from the mouse submandibular gland: decreased Na+ content in saliva results from specific and early activation of Na+/H+ exchange.J Pharmacol Exp Ther. 2011 Apr;337(1):267-74. Epub 2011 Jan 14.

Title: Voskoboynik B, et al.Cevimeline (Evoxac) overdose.J Med Toxicol. 2011 Mar;7(1):57-9.

Title: Mitoh Y, et al. Effects of cevimeline on excitability of parasympathetic preganglionic neurons in the superior salivatory nucleus of rats. Auton Neurosci. 2017 Sep;206:1-7.

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Related Products of 153504-70-2
Tags:153504-70-2 Molecular Formula|153504-70-2 MDL|153504-70-2 SMILES|153504-70-2 Cevimelinehydrochloride
Catalog No.: AA00ABGP
153504-70-2,MFCD01759988
153504-70-2 | Cevimelinehydrochloride
Pack Size: 2mg
Purity:
1 week
$98.00 $68.00
Pack Size: 5mg
Purity:
1 week
$123.00 $86.00
Pack Size: 10mg
Purity:
1 week
$168.00 $118.00
Pack Size: 25mg
Purity:
1 week
$259.00 $181.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA00ABGP
Chemical Name: Cevimelinehydrochloride
CAS Number: 153504-70-2
Molecular Formula: C20H38Cl2N2O3S2
Molecular Weight: 489.5633
MDL Number: MFCD01759988
SMILES: CC1SCC2(O1)CN1CCC2CC1.CC1SCC2(O1)CN1CCC2CC1.O.Cl.Cl
Properties
Complexity: 215  
Covalently-Bonded Unit Count: 5  
Defined Atom Stereocenter Count: 2  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 29  
Hydrogen Bond Acceptor Count: 7  
Hydrogen Bond Donor Count: 3  
Isotope Atom Count: 0  
Rotatable Bond Count: 0  
Undefined Atom Stereocenter Count: 2  
Undefined Bond Stereocenter Count: 0  
Literature fold

Title: Effectiveness of cevimeline to improve oral health in patients with postradiation xerostomia.

Journal: Head & neck20120801

Title: Distinct effects of cevimeline and pilocarpine on salivary mechanisms, cardiovascular response and thirst sensation in rats.

Journal: Archives of oral biology20120401

Title: Treatment of Sjögren's syndrome-associated dry eye an evidence-based review.

Journal: Ophthalmology20110701

Title: Abnormal subcellular localization of AQP5 and downregulated AQP5 protein in parotid glands of streptozotocin-induced diabetic rats.

Journal: Biochimica et biophysica acta20110501

Title: Cevimeline-induced monophasic salivation from the mouse submandibular gland: decreased Na+ content in saliva results from specific and early activation of Na+/H+ exchange.

Journal: The Journal of pharmacology and experimental therapeutics20110401

Title: Cevimeline (Evoxac ®) overdose.

Journal: Journal of medical toxicology : official journal of the American College of Medical Toxicology20110301

Title: New epitopes and function of anti-M3 muscarinic acetylcholine receptor antibodies in patients with Sjögren's syndrome.

Journal: Clinical and experimental immunology20101001

Title: The relationship between the drug concentration profiles in plasma and the drug doses in the colon.

Journal: Chemical & pharmaceutical bulletin20101001

Title: Dosage form design and in vitro/in vivo evaluation of cevimeline extended-release tablet formulations.

Journal: International journal of pharmaceutics20100104

Title: Comparison of the effects of pilocarpine and cevimeline on salivary flow.

Journal: International journal of dental hygiene20090501

Title: Identification of aquaporin-5 and lipid rafts in human resting saliva and their release into cevimeline-stimulated saliva.

Journal: Biochimica et biophysica acta20090101

Title: Sjögren's syndrome patients presenting with hypergammaglobulinemia are relatively unresponsive to cevimeline treatment.

Journal: Modern rheumatology20090101

Title: Cevimeline enhances the excitability of rat superior salivatory neurons.

Journal: The journal of medical investigation : JMI20090101

Title: Correlation between salivary secretion and salivary AQP5 levels in health and disease.

Journal: The journal of medical investigation : JMI20090101

Title: Effects of pilocarpine and cevimeline on Ca2+ mobilization in rat parotid acini and ducts.

Journal: The journal of medical investigation : JMI20090101

Title: Effects of cevimeline on the immunolocalization of aquaporin-5 and the ultrastructure of salivary glands in Sjögren's syndrome model mice.

Journal: The Kurume medical journal20090101

Title: Parotid irrigation and cevimeline gargle for treatment of xerostomia in Sjögren's syndrome.

Journal: The Journal of rheumatology20081101

Title: Degradation of submandibular gland AQP5 by parasympathetic denervation of chorda tympani and its recovery by cevimeline, an M3 muscarinic receptor agonist.

Journal: American journal of physiology. Gastrointestinal and liver physiology20080701

Title: The efficacy of cevimeline hydrochloride in the treatment of xerostomia in Sjögren's syndrome in southern Chinese patients: a randomised double-blind, placebo-controlled crossover study.

Journal: Clinical rheumatology20080401

Title: Cevimeline.

Journal: Drugs20080101

Title: Open-label, long-term safety study of cevimeline in the treatment of postirradiation xerostomia.

Journal: International journal of radiation oncology, biology, physics20071201

Title: Xerostomia: causes and treatment.

Journal: The Consultant pharmacist : the journal of the American Society of Consultant Pharmacists20071201

Title: Effect of a muscarinic M3 receptor agonist on gastric motility.

Journal: Journal of gastroenterology and hepatology20071101

Title: Efficacy prediction of cevimeline in patients with Sjögren's syndrome.

Journal: Clinical rheumatology20070801

Title: Cevimeline for the treatment of postirradiation xerostomia in patients with head and neck cancer.

Journal: International journal of radiation oncology, biology, physics20070715

Title: Effect of cevimeline on radiation-induced salivary gland dysfunction and AQP5 in submandibular gland in mice.

Journal: The Bulletin of Tokyo Dental College20070501

Title: Salivary dysfunction associated with systemic diseases: systematic review and clinical management recommendations.

Journal: Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics20070301

Title: [Revision of the recommendations of the Commission on Pharmacotherapy of the German Society for Rheumatology. Recommendations for supportive therapy for Sjögren's syndrome].

Journal: Zeitschrift fur Rheumatologie20070201

Title: Effects of cevimeline on salivation and thirst in conscious rats.

Journal: Archives of oral biology20070101

Title: Unraveling the mysteries of saliva: its importance in maintaining oral health. Transcript of a lecture presented on August 6 at the 2006 AGD Annual Meeting & Exposition.

Journal: General dentistry20070101

Title: The therapy of Sjogren's syndrome: a review.

Journal: La Clinica terapeutica20070101

Title: Cevimeline reduced mouth dryness and increased salivary flow in patients with xerostomia complicating chronic graft-versus-host disease.

Journal: Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation20060701

Title: New approaches to preventing xerostomia.

Journal: The journal of supportive oncology20060201

Title: Cevimeline hydrochloride improved cholinergic dysfunction in a patient with pure autonomic failure.

Journal: Journal of neurology20060101

Title: Assessment of the use of sialogogues in the clinical management of patients with xerostomia.

Journal: Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry20060101

Title: Management of xerostomia related to radiotherapy for head and neck cancer.

Journal: Oncology (Williston Park, N.Y.)20051201

Title: Identification of AQP5 in lipid rafts and its translocation to apical membranes by activation of M3 mAChRs in interlobular ducts of rat parotid gland.

Journal: American journal of physiology. Cell physiology20051101

Title: Idiopathic CD4+ lymphocytopenia and Sjogren syndrome.

Journal: Archives of ophthalmology (Chicago, Ill. : 1960)20050701

Title: Effect of cevimeline on salivary components in patients with Sjögren syndrome.

Journal: Pharmacology20050501

Title: Salivary hypofunction and xerostomia: diagnosis and treatment.

Journal: Dental clinics of North America20050401

Title: Dentistry. Implications and management of xerostomia in the HIV patient.

Journal: HIV clinician20050101

Title: Dentistry. Clinic assesses effect of medication on dry mouth syndrome.

Journal: HIV clinician20050101

Title: Xerostomia secondary to Sjögren's syndrome in the elderly: recognition and management.

Journal: Drugs & aging20050101

Title: [Clinical significance of cevimeline hydrochloride in the treatment of dry mouth in patients with Sjögren's syndrome].

Journal: Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology20041001

Title: Therapeutic effect of cevimeline on dry eye in patients with Sjögren's syndrome: a randomized, double-blind clinical study.

Journal: American journal of ophthalmology20040701

Title: [Future therapy strategies for salivary gland impairment].

Journal: Refu'at ha-peh veha-shinayim (1993)20040701

Title: Cevimeline gargle for the treatment of xerostomia in patients with Sjögren's syndrome.

Journal: Annals of the rheumatic diseases20040601

Title: [The effectiveness of cevimeline hydrochloride on dry cough in Sjögren's syndrome].

Journal: Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology20040401

Title: Radiation-induced xerostomia: how dry is your patient?

Journal: Clinical journal of oncology nursing20040201

Title: Ligand-selective signaling and high-content screening for GPCR drugs.

Journal: Drug discovery today20031215

Title: Reduction in distractibility with AF102B and THA in the macaque.

Journal: Pharmacology, biochemistry, and behavior20030901

Title: Age-related decreases in the response of aquaporin-5 to acetylcholine in rat parotid glands.

Journal: Journal of dental research20030601

Title: Current therapies for xerostomia and salivary gland hypofunction associated with cancer therapies.

Journal: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer20030401

Title: Effect of SNI-2011 on amylase secretion from parotid tissue in rats and in neuronal nitric oxide synthase knockout mice.

Journal: European journal of pharmacology20030319

Title: Pharmacokinetics and metabolism of the novel muscarinic receptor agonist SNI-2011 in rats and dogs.

Journal: Arzneimittel-Forschung20030101

Title: Pharmacokinetics and metabolism of radiolabelled SNI-2011, a novel muscarinic receptor agonist, in healthy volunteers. Comprehensive understanding of absorption, metabolism and excretion using radiolabelled SNI-2011.

Journal: Arzneimittel-Forschung20030101

Title: Effects of pilocarpine hydrochloride and cevimeline on submandibular/sublingual salivation in rat xerostomia model produced by X-ray irradiation.

Journal: Arzneimittel-Forschung20030101

Title: M1 muscarinic agonists can modulate some of the hallmarks in Alzheimer's disease: implications in future therapy.

Journal: Journal of molecular neuroscience : MN20030101

Title: [Cevimeline hydrochloride hydrate (Saligren capsule 30 mg): a review of its pharmacological profiles and clinical potential in xerostomia].

Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica20021001

Title: Cevimeline for the treatment of xerostomia in patients with Sjögren syndrome: a randomized trial.

Journal: Archives of internal medicine20020610

Title: Assessing salivary gland hypofunction--Part two.

Journal: Practical procedures & aesthetic dentistry : PPAD20020401

Title: A double-blind, randomized, placebo-controlled study of cevimeline in Sjögren's syndrome patients with xerostomia and keratoconjunctivitis sicca.

Journal: Arthritis and rheumatism20020301

Title: General pharmacological profile of the novel muscarinic receptor agonist SNI-2011, a drug for xerostomia in Sjögren's syndrome. 1st communication: effects on general behavior and central nervous system.

Journal: Arzneimittel-Forschung20020101

Title: General pharmacological profile of the novel muscarinic receptor agonist SNI-2011, a drug for xerostomia in Sjögren's syndrome. 2nd communication: effects on somatic nervous system and on autonomic nervous system and smooth muscle.

Journal: Arzneimittel-Forschung20020101

Title: General pharmacological profile of the novel muscarinic receptor agonist SNI-2011, a drug for xerostomia in Sjögren's syndrome. 3rd communication: effects on respiratory and cardiovascular systems.

Journal: Arzneimittel-Forschung20020101

Title: General pharmacological profile of the novel muscarinic receptor agonist SNI-2011, a drug for xerostomia in Sjögren's syndrome. 4th communication: Effects on gastrointestinal, urinary and reproductive systems and other effects.

Journal: Arzneimittel-Forschung20020101

Title: Use of cevimeline, a muscarinic M1 and M3 agonist, in the treatment of Sjögren's syndrome.

Journal: Advances in experimental medicine and biology20020101

Title: Use of muscarinic agonists in the treatment of Sjögren's syndrome.

Journal: Clinical immunology (Orlando, Fla.)20011201

Title: Identification of human drug-metabolizing enzymes involved in the metabolism of SNI-2011.

Journal: Biological & pharmaceutical bulletin20011101

Title: Salivary enhancement: current status and future therapies.

Journal: Journal of dental education20011001

Title: Reduction of cerebrospinal fluid amyloid beta after systemic administration of M1 muscarinic agonists.

Journal: Brain research20010629

Title: A new medication for treatment of dry mouth in Sjögren's syndrome.

Journal: Texas dental journal20010401

Title: New drug approvals in 2000.

Journal: General dentistry20010101

Title: AF102B, a muscarinic M1 receptor agonist, mimics some effects of acetylcholine on neurons of rat hippocampus slices.

Journal: European journal of pharmacology19920910

Title: Central muscarinic activities of an M1-selective agonist: preferential effect on reversal of amnesia.

Journal: Brain research19900115

Title: Amelioration of experimental amnesia (passive avoidance failure) in rodents by the selective M1 agonist AF102B.

Journal: Japanese journal of pharmacology19881201

Title: Ono K, et al. Distinct effects of cevimeline and pilocarpine on salivary mechanisms, cardiovascular response and thirst sensation in rats.Arch Oral Biol. 2012 Apr;57(4):421-8. Epub 2011 Nov 17.

Title: Witsell DL, et al. Effectiveness of cevimeline to improve oral health in patients with postradiation xerostomia.Head Neck. 2012 Aug;34(8):1136-42. doi: 10.1002/hed.21894. Epub 2012 Jan 9.

Title: Kondo Y, et al.Cevimeline-induced monophasic salivation from the mouse submandibular gland: decreased Na+ content in saliva results from specific and early activation of Na+/H+ exchange.J Pharmacol Exp Ther. 2011 Apr;337(1):267-74. Epub 2011 Jan 14.

Title: Voskoboynik B, et al.Cevimeline (Evoxac) overdose.J Med Toxicol. 2011 Mar;7(1):57-9.

Title: Mitoh Y, et al. Effects of cevimeline on excitability of parasympathetic preganglionic neurons in the superior salivatory nucleus of rats. Auton Neurosci. 2017 Sep;206:1-7.

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1579991-61-9
1579991-61-9
Chitinase-IN-1
AA00ABKM | MFCD28385840
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AA00ABPN | MFCD28502088
152213-61-1
152213-61-1
6-Bromoindole-3-acetonitrile
AA00ABYV | MFCD09954794
17288-35-6
17288-35-6
1H-Pyrrolo[3,2-b]pyridine-2-carboxylic acid
AA00ACA6 | MFCD09955613
15474-90-5
15474-90-5
Histidine dihydrochloride
AA00ACP6 | MFCD00035203
160358-06-5
160358-06-5
1-(2-Fluorobenzyl)piperidin-4-amine dihydrochloride
AA00ACUV | MFCD07365306
171440-18-9
171440-18-9
Dexrabeprazole sodium
AA00AD2N | MFCD11840547
168214-67-3
168214-67-3
1,1-dimethyl-2-benzoxepin-3-yl)phenyl]ethenyl]-
AA00AD8G | MFCD21496335
175613-38-4
175613-38-4
9-HydroxyMethyl-10-hydroxy CaMptothecin
AA00ADEU
156968-81-9
156968-81-9
[1',2',3',4',5'-13C5]THYMIDINE
AA00ADNA | MFCD08459922
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