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107233-08-9,MFCD22577792
Catalog No.:AA0082C4

107233-08-9 | Cevimeline

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10mg
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50mg
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA0082C4
Chemical Name:
Cevimeline
CAS Number:
107233-08-9
Molecular Formula:
C10H17NOS
Molecular Weight:
199.3131
MDL Number:
MFCD22577792
SMILES:
C[C@H]1SC[C@]2(O1)CN1CCC2CC1
Properties
Computed Properties
 
Complexity:
215  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Heavy Atom Count:
13  
Hydrogen Bond Acceptor Count:
3  
XLogP3:
1.5  

Literature

Title: Effectiveness of cevimeline to improve oral health in patients with postradiation xerostomia.

Journal: Head & neck 20120801

Title: Distinct effects of cevimeline and pilocarpine on salivary mechanisms, cardiovascular response and thirst sensation in rats.

Journal: Archives of oral biology 20120401

Title: Treatment of Sjögren's syndrome-associated dry eye an evidence-based review.

Journal: Ophthalmology 20110701

Title: Abnormal subcellular localization of AQP5 and downregulated AQP5 protein in parotid glands of streptozotocin-induced diabetic rats.

Journal: Biochimica et biophysica acta 20110501

Title: Cevimeline-induced monophasic salivation from the mouse submandibular gland: decreased Na+ content in saliva results from specific and early activation of Na+/H+ exchange.

Journal: The Journal of pharmacology and experimental therapeutics 20110401

Title: Cevimeline (Evoxac ®) overdose.

Journal: Journal of medical toxicology : official journal of the American College of Medical Toxicology 20110301

Title: New epitopes and function of anti-M3 muscarinic acetylcholine receptor antibodies in patients with Sjögren's syndrome.

Journal: Clinical and experimental immunology 20101001

Title: The relationship between the drug concentration profiles in plasma and the drug doses in the colon.

Journal: Chemical & pharmaceutical bulletin 20101001

Title: Dosage form design and in vitro/in vivo evaluation of cevimeline extended-release tablet formulations.

Journal: International journal of pharmaceutics 20100104

Title: [Analysis of epitopes and function of anti-M3 muscarinic acetylcholine receptor antibodies in patients with Sjögren's syndrome].

Journal: Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology 20100101

Title: Comparison of the effects of pilocarpine and cevimeline on salivary flow.

Journal: International journal of dental hygiene 20090501

Title: Identification of aquaporin-5 and lipid rafts in human resting saliva and their release into cevimeline-stimulated saliva.

Journal: Biochimica et biophysica acta 20090101

Title: Sjögren's syndrome patients presenting with hypergammaglobulinemia are relatively unresponsive to cevimeline treatment.

Journal: Modern rheumatology 20090101

Title: Cevimeline enhances the excitability of rat superior salivatory neurons.

Journal: The journal of medical investigation : JMI 20090101

Title: Correlation between salivary secretion and salivary AQP5 levels in health and disease.

Journal: The journal of medical investigation : JMI 20090101

Title: Effects of pilocarpine and cevimeline on Ca2+ mobilization in rat parotid acini and ducts.

Journal: The journal of medical investigation : JMI 20090101

Title: Effects of cevimeline on the immunolocalization of aquaporin-5 and the ultrastructure of salivary glands in Sjögren's syndrome model mice.

Journal: The Kurume medical journal 20090101

Title: Parotid irrigation and cevimeline gargle for treatment of xerostomia in Sjögren's syndrome.

Journal: The Journal of rheumatology 20081101

Title: Degradation of submandibular gland AQP5 by parasympathetic denervation of chorda tympani and its recovery by cevimeline, an M3 muscarinic receptor agonist.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20080701

Title: The efficacy of cevimeline hydrochloride in the treatment of xerostomia in Sjögren's syndrome in southern Chinese patients: a randomised double-blind, placebo-controlled crossover study.

Journal: Clinical rheumatology 20080401

Title: Cevimeline.

Journal: Drugs 20080101

Title: Open-label, long-term safety study of cevimeline in the treatment of postirradiation xerostomia.

Journal: International journal of radiation oncology, biology, physics 20071201

Title: Xerostomia: causes and treatment.

Journal: The Consultant pharmacist : the journal of the American Society of Consultant Pharmacists 20071201

Title: Effect of a muscarinic M3 receptor agonist on gastric motility.

Journal: Journal of gastroenterology and hepatology 20071101

Title: Efficacy prediction of cevimeline in patients with Sjögren's syndrome.

Journal: Clinical rheumatology 20070801

Title: Cevimeline for the treatment of postirradiation xerostomia in patients with head and neck cancer.

Journal: International journal of radiation oncology, biology, physics 20070715

Title: Effect of cevimeline on radiation-induced salivary gland dysfunction and AQP5 in submandibular gland in mice.

Journal: The Bulletin of Tokyo Dental College 20070501

Title: Salivary dysfunction associated with systemic diseases: systematic review and clinical management recommendations.

Journal: Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 20070301

Title: [Revision of the recommendations of the Commission on Pharmacotherapy of the German Society for Rheumatology. Recommendations for supportive therapy for Sjögren's syndrome].

Journal: Zeitschrift fur Rheumatologie 20070201

Title: Effects of cevimeline on salivation and thirst in conscious rats.

Journal: Archives of oral biology 20070101

Title: Unraveling the mysteries of saliva: its importance in maintaining oral health. Transcript of a lecture presented on August 6 at the 2006 AGD Annual Meeting & Exposition.

Journal: General dentistry 20070101

Title: The therapy of Sjogren's syndrome: a review.

Journal: La Clinica terapeutica 20070101

Title: Cevimeline reduced mouth dryness and increased salivary flow in patients with xerostomia complicating chronic graft-versus-host disease.

Journal: Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 20060701

Title: New approaches to preventing xerostomia.

Journal: The journal of supportive oncology 20060201

Title: Cevimeline hydrochloride improved cholinergic dysfunction in a patient with pure autonomic failure.

Journal: Journal of neurology 20060101

Title: Assessment of the use of sialogogues in the clinical management of patients with xerostomia.

Journal: Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry 20060101

Title: Management of xerostomia related to radiotherapy for head and neck cancer.

Journal: Oncology (Williston Park, N.Y.) 20051201

Title: Identification of AQP5 in lipid rafts and its translocation to apical membranes by activation of M3 mAChRs in interlobular ducts of rat parotid gland.

Journal: American journal of physiology. Cell physiology 20051101

Title: Idiopathic CD4+ lymphocytopenia and Sjogren syndrome.

Journal: Archives of ophthalmology (Chicago, Ill. : 1960) 20050701

Title: Prediction of genotoxicity of chemical compounds by statistical learning methods.

Journal: Chemical research in toxicology 20050601

Title: Effect of cevimeline on salivary components in patients with Sjögren syndrome.

Journal: Pharmacology 20050501

Title: Salivary hypofunction and xerostomia: diagnosis and treatment.

Journal: Dental clinics of North America 20050401

Title: Dentistry. Implications and management of xerostomia in the HIV patient.

Journal: HIV clinician 20050101

Title: Dentistry. Clinic assesses effect of medication on dry mouth syndrome.

Journal: HIV clinician 20050101

Title: Xerostomia secondary to Sjögren's syndrome in the elderly: recognition and management.

Journal: Drugs & aging 20050101

Title: [Clinical significance of cevimeline hydrochloride in the treatment of dry mouth in patients with Sjögren's syndrome].

Journal: Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology 20041001

Title: Therapeutic effect of cevimeline on dry eye in patients with Sjögren's syndrome: a randomized, double-blind clinical study.

Journal: American journal of ophthalmology 20040701

Title: [Future therapy strategies for salivary gland impairment].

Journal: Refu'at ha-peh veha-shinayim (1993) 20040701

Title: Cevimeline gargle for the treatment of xerostomia in patients with Sjögren's syndrome.

Journal: Annals of the rheumatic diseases 20040601

Title: [The effectiveness of cevimeline hydrochloride on dry cough in Sjögren's syndrome].

Journal: Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology 20040401

Title: Radiation-induced xerostomia: how dry is your patient?

Journal: Clinical journal of oncology nursing 20040201

Title: Transplantation of cultured salivary gland cells into an atrophic salivary gland.

Journal: Cell transplantation 20040101

Title: Ligand-selective signaling and high-content screening for GPCR drugs.

Journal: Drug discovery today 20031215

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20030901

Title: Reduction in distractibility with AF102B and THA in the macaque.

Journal: Pharmacology, biochemistry, and behavior 20030901

Title: Age-related decreases in the response of aquaporin-5 to acetylcholine in rat parotid glands.

Journal: Journal of dental research 20030601

Title: Current therapies for xerostomia and salivary gland hypofunction associated with cancer therapies.

Journal: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20030401

Title: Effect of SNI-2011 on amylase secretion from parotid tissue in rats and in neuronal nitric oxide synthase knockout mice.

Journal: European journal of pharmacology 20030319

Title: Pharmacokinetics and metabolism of the novel muscarinic receptor agonist SNI-2011 in rats and dogs.

Journal: Arzneimittel-Forschung 20030101

Title: Pharmacokinetics and metabolism of radiolabelled SNI-2011, a novel muscarinic receptor agonist, in healthy volunteers. Comprehensive understanding of absorption, metabolism and excretion using radiolabelled SNI-2011.

Journal: Arzneimittel-Forschung 20030101

Title: Effects of pilocarpine hydrochloride and cevimeline on submandibular/sublingual salivation in rat xerostomia model produced by X-ray irradiation.

Journal: Arzneimittel-Forschung 20030101

Title: M1 muscarinic agonists can modulate some of the hallmarks in Alzheimer's disease: implications in future therapy.

Journal: Journal of molecular neuroscience : MN 20030101

Title: [Cevimeline hydrochloride hydrate (Saligren capsule 30 mg): a review of its pharmacological profiles and clinical potential in xerostomia].

Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20021001

Title: Cevimeline for the treatment of xerostomia in patients with Sjögren syndrome: a randomized trial.

Journal: Archives of internal medicine 20020610

Title: Assessing salivary gland hypofunction--Part two.

Journal: Practical procedures & aesthetic dentistry : PPAD 20020401

Title: A double-blind, randomized, placebo-controlled study of cevimeline in Sjögren's syndrome patients with xerostomia and keratoconjunctivitis sicca.

Journal: Arthritis and rheumatism 20020301

Title: General pharmacological profile of the novel muscarinic receptor agonist SNI-2011, a drug for xerostomia in Sjögren's syndrome. 1st communication: effects on general behavior and central nervous system.

Journal: Arzneimittel-Forschung 20020101

Title: General pharmacological profile of the novel muscarinic receptor agonist SNI-2011, a drug for xerostomia in Sjögren's syndrome. 2nd communication: effects on somatic nervous system and on autonomic nervous system and smooth muscle.

Journal: Arzneimittel-Forschung 20020101

Title: General pharmacological profile of the novel muscarinic receptor agonist SNI-2011, a drug for xerostomia in Sjögren's syndrome. 3rd communication: effects on respiratory and cardiovascular systems.

Journal: Arzneimittel-Forschung 20020101

Title: General pharmacological profile of the novel muscarinic receptor agonist SNI-2011, a drug for xerostomia in Sjögren's syndrome. 4th communication: Effects on gastrointestinal, urinary and reproductive systems and other effects.

Journal: Arzneimittel-Forschung 20020101

Title: Use of cevimeline, a muscarinic M1 and M3 agonist, in the treatment of Sjögren's syndrome.

Journal: Advances in experimental medicine and biology 20020101

Title: Use of muscarinic agonists in the treatment of Sjögren's syndrome.

Journal: Clinical immunology (Orlando, Fla.) 20011201

Title: Identification of human drug-metabolizing enzymes involved in the metabolism of SNI-2011.

Journal: Biological & pharmaceutical bulletin 20011101

Title: Salivary enhancement: current status and future therapies.

Journal: Journal of dental education 20011001

Title: Reduction of cerebrospinal fluid amyloid beta after systemic administration of M1 muscarinic agonists.

Journal: Brain research 20010629

Title: A new medication for treatment of dry mouth in Sjögren's syndrome.

Journal: Texas dental journal 20010401

Title: New drug approvals in 2000.

Journal: General dentistry 20010101

Title: AF102B, a muscarinic M1 receptor agonist, mimics some effects of acetylcholine on neurons of rat hippocampus slices.

Journal: European journal of pharmacology 19920910

Title: Central muscarinic activities of an M1-selective agonist: preferential effect on reversal of amnesia.

Journal: Brain research 19900115

Title: Amelioration of experimental amnesia (passive avoidance failure) in rodents by the selective M1 agonist AF102B.

Journal: Japanese journal of pharmacology 19881201

Title: Ono K, et al. Distinct effects of cevimeline and pilocarpine on salivary mechanisms, cardiovascular response and thirst sensation in rats.Arch Oral Biol. 2012 Apr;57(4):421-8. Epub 2011 Nov 17.

Title: Witsell DL, et al. Effectiveness of cevimeline to improve oral health in patients with postradiation xerostomia.Head Neck. 2012 Aug;34(8):1136-42. doi: 10.1002/hed.21894. Epub 2012 Jan 9.

Title: Kondo Y, et al.Cevimeline-induced monophasic salivation from the mouse submandibular gland: decreased Na+ content in saliva results from specific and early activation of Na+/H+ exchange.J Pharmacol Exp Ther. 2011 Apr;337(1):267-74. Epub 2011 Jan 14.

Title: Voskoboynik B, et al.Cevimeline (Evoxac) overdose.J Med Toxicol. 2011 Mar;7(1):57-9.

Title: Mitoh Y, et al. Effects of cevimeline on excitability of parasympathetic preganglionic neurons in the superior salivatory nucleus of rats. Auton Neurosci. 2017 Sep;206:1-7.

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