Home Amines 15421-84-8
15421-84-8,MFCD00193104
Catalog No.:AA007GEP

15421-84-8 | [1,2,4]Triazolo[1,5-a]pyrimidin-7-amine,N,N-diethyl-5-methyl-

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1mg
98%
in stock  
$6.00   $4.00
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5mg
98%
in stock  
$7.00   $5.00
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10mg
98%
in stock  
$9.00   $7.00
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50mg
98%
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$28.00   $20.00
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250mg
98%
in stock  
$95.00   $67.00
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1g
98%
in stock  
$211.00   $148.00
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5g
98%
in stock  
$610.00   $427.00
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10g
98%
in stock  
$1,009.00   $706.00
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25g
98%
in stock  
$2,007.00   $1,405.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA007GEP
Chemical Name:
[1,2,4]Triazolo[1,5-a]pyrimidin-7-amine,N,N-diethyl-5-methyl-
CAS Number:
15421-84-8
Molecular Formula:
C10H15N5
Molecular Weight:
205.2596
MDL Number:
MFCD00193104
SMILES:
CCN(c1cc(C)nc2n1ncn2)CC
Properties
Computed Properties
 
Complexity:
206  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
15  
Hydrogen Bond Acceptor Count:
4  
Rotatable Bond Count:
3  
XLogP3:
1.7  

Literature

Title: Effects of the antianginal drug trapidil on atrioventricular conduction disturbances during acute myocardial ischemia.

Journal: International heart journal 20120101

Title: Adenosine and blood platelets.

Journal: Purinergic signalling 20110901

Title: Voltage-gated calcium channels.

Journal: Cold Spring Harbor perspectives in biology 20110801

Title: Optical coherence tomography in ST-elevation myocardial infarction treated with novel drug-eluting stent: preprocedural, postimplant and 2-month follow-up findings.

Journal: Journal of cardiovascular medicine (Hagerstown, Md.) 20110101

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Rationale and study design of the OISTER trial: optical coherence tomography evaluation of stent struts re-endothelialization in patients with non-ST-elevation acute coronary syndromes--a comparison of the intrEpide tRapidil eluting stent vs. taxus drug-eluting stent implantation.

Journal: Journal of cardiovascular medicine (Hagerstown, Md.) 20100701

Title: The role of mast cells in parathyroid bone disease.

Journal: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20100701

Title: Antithrombotic therapy for improving maternal or infant health outcomes in women considered at risk of placental dysfunction.

Journal: The Cochrane database of systematic reviews 20100616

Title: [Investigation of the effects of low dose aspirin therapy on primary and secondary prevention of cardiovascular disease].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20100501

Title: Platelet-derived growth factor-induced severe and chronic vasoconstriction of cerebral arteries: proposed growth factor explanation of cerebral vasospasm.

Journal: Neurosurgery 20100401

Title: Protective effect of trapidil and l-arginine against renal and hepatic toxicity induced by cyclosporine in rats.

Journal: Renal failure 20100101

Title: Clinical evidence for Japanese population based on prospective studies--linking clinical trials and clinical practice.

Journal: Journal of cardiology 20091001

Title: Contact line pinning by microfabricated patterns: effects of microscale topography.

Journal: Langmuir : the ACS journal of surfaces and colloids 20090505

Title: Protective effect of trapidil on long-term histologic damage in a rat model of testicular ischemia-reperfusion injury.

Journal: World journal of urology 20090201

Title: Osteitis fibrosa is mediated by Platelet-Derived Growth Factor-A via a phosphoinositide 3-kinase-dependent signaling pathway in a rat model for chronic hyperparathyroidism.

Journal: Endocrinology 20081101

Title: Intrepide; Trapidil eluting stent.

Journal: EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology 20081101

Title: A note on population analysis of dissolution-absorption models using the inverse Gaussian function.

Journal: Journal of clinical pharmacology 20080601

Title: The role of trapidil on neuronal apoptosis in neonatal rat model of hypoxic ischemic brain injury.

Journal: Early human development 20080401

Title: Ischemia-reperfusion injury of rabbit ovary and protective effect of trapidil: an experimental study.

Journal: Pediatric surgery international 20080301

Title: Determination of trapidil in human serum and urine by derivative UV spectrophotometry after selective solid-phase extraction.

Journal: Analytical and bioanalytical chemistry 20071001

Title: Pharmacologic approaches to restenosis prevention.

Journal: The American journal of cardiology 20070903

Title: Effects of low dose trapidil on electrical properties of a rat peripheral nerve after crush injury.

Journal: Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES 20070701

Title: Effect of characteristics of compounds on maintenance of an amorphous state in solid dispersion with crospovidone.

Journal: Journal of pharmaceutical sciences 20070601

Title: CD40-CD40 ligand mediates the recruitment of leukocytes and platelets in the inflamed murine colon.

Journal: Gastroenterology 20070301

Title: Effect of locally applied trapidil on norepinephrine- and dinoprost-evoked hand vein constriction in healthy men.

Journal: International journal of clinical pharmacology and therapeutics 20070101

Title: Influence of systemically given placebo, trapidil and isosorbide dinitrate on norepinephrine-evoked hand vein constriction in healthy subjects.

Journal: Arzneimittel-Forschung 20070101

Title: Effects of trapidil on renal ischemia-reperfusion injury.

Journal: Journal of pediatric surgery 20061001

Title: Trapidil decreases the aggregation of platelets from heart transplant recipients ex vivo.

Journal: Transplantation proceedings 20060601

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Protective effects of trapidil in ischemia-reperfusion injury due to testicular torsion and detorsion: an experimental study.

Journal: International journal of urology : official journal of the Japanese Urological Association 20060501

Title: Trapidil is as effective as isosorbide-dinitrate for treating stable angina pectoris: a multinational, multicenter, double-blind, randomized study.

Journal: Clinical research in cardiology : official journal of the German Cardiac Society 20060401

Title: Protective effects of trapidil in lung after abdominal aorta induced ischemia-reperfusion injury: an experimental study.

Journal: Pediatric surgery international 20051201

Title: Protective effect of trapidil against oxidative organ damage in burn injury.

Journal: Burns : journal of the International Society for Burn Injuries 20051101

Title: Trapidil, an inhibitor for phosphodiesterase and platelet-derived-growth factor, ameliorates corrosive esophageal burn in rats.

Journal: The Tohoku journal of experimental medicine 20051101

Title: Trapidil enhances the slowly activating delayed rectifier potassium current and suppresses the transient inward current induced by catecholamine in Guinea pig ventricular myocytes.

Journal: Journal of cardiovascular pharmacology 20050801

Title: Trapidil inhibits platelet-derived growth factor-induced migration via protein kinase A and RhoA/Rho-associated kinase in rat vascular smooth muscle cells.

Journal: European journal of pharmacology 20050516

Title: Effects of trapidil after crush injury in peripheral nerve.

Journal: Acta medica Okayama 20050401

Title: Starc II, a multicenter randomized placebo-controlled double-blind clinical trial of trapidil for 1-year clinical events and angiographic restenosis reduction after coronary angioplasty and stenting.

Journal: Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 20050301

Title: Effects of triazolopyrimidine on lipid peroxidation and nitric oxide levels in the corticosteroid-impaired healing of rat tracheal anastomoses.

Journal: Cell biochemistry and function 20050101

Title: Trapidil inhibits monocyte CD40 expression by preventing IFN-gamma-induced STAT1 S727 phosphorylation.

Journal: International immunopharmacology 20040701

Title: Matrix metalloproteinase 2 is suppressed by trapidil, a CD40-CD40 ligand pathway inhibitor, in human abdominal aortic aneurysm wall.

Journal: Journal of vascular surgery 20040201

Title: Effects of trapidil on the healing of colonic anastomoses in an experimental rat model.

Journal: ANZ journal of surgery 20031101

Title: Effect of trapidil on cardiovascular events in patients with coronary artery disease (results from the Japan Multicenter Investigation for Cardiovascular Diseases-Mochida [JMIC-M]).

Journal: The American journal of cardiology 20031001

Title: Activation of Src kinase in platelet-derived growth factor-B-dependent tubular regeneration after acute ischemic renal injury.

Journal: The American journal of pathology 20030701

Title: Trapidil protects ischemic hearts from reperfusion injury by stimulating PKAII activity.

Journal: Cardiovascular research 20030601

Title: Triazolopyrimidine (trapidil), a platelet-derived growth factor antagonist, inhibits parathyroid bone disease in an animal model for chronic hyperparathyroidism.

Journal: Endocrinology 20030501

Title: [Prevention of postangioplasty restenosis].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20030401

Title: Effect of trapidil in ischemia/reperfusion injury on rat small intestine.

Journal: Journal of investigative surgery : the official journal of the Academy of Surgical Research 20030101

Title: Extracellular signal regulated kinases are key mediators of mitogenic signals in rat pancreatic stellate cells.

Journal: Gut 20021001

Title: Effect of trapidil in ischemia/reperfusion injury of peripheral nerves.

Journal: Neurosurgery 20020701

Title: Resolution of cerebral vasospasm with trapidil; an animal model.

Journal: Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 20020701

Title: [Balloon dilatation plus PDGF antagonist. With this coronary arteries remain patent].

Journal: MMW Fortschritte der Medizin 20011018

Title: Effect of trapidil on effector functions of monocytes related to atherosclerotic plaque.

Journal: European journal of pharmacology 20011012

Title: Effect of trapidil, an antiplatelet and vasodilator agent on gentamicin-induced nephrotoxicity in rats.

Journal: Pharmacological research 20011001

Title: A monk's prayer: O Lord what is the answer to in-stent restenosis? Commentary on the TRAPIST Study.

Journal: European heart journal 20011001

Title: The TRAPIST Study. A multicentre randomized placebo controlled clinical trial of trapidil for prevention of restenosis after coronary stenting, measured by 3-D intravascular ultrasound.

Journal: European heart journal 20011001

Title: Effects of trapidil on ATPase, lipid peroxidation, and correlation with ultrastructure in experimental spinal cord injury.

Journal: Neurosurgical review 20010701

Title: Trapidil inhibits platelet-derived growth factor-stimulated mitogen-activated protein kinase cascade.

Journal: Hypertension (Dallas, Tex. : 1979) 19980201

Title: Pharmacokinetics of trapidil, an antagonist of platelet derived growth factor, in healthy subjects and in patients with liver cirrhosis.

Journal: British journal of clinical pharmacology 19961001

Title: Decrease of platelet aggregation and spreading via inhibition of the cAMP phosphodiesterase by trapidil.

Journal: FEBS letters 19840709

Title: Trapidil stimulation of slow Ca2+ current in cardiac muscle.

Journal: European journal of pharmacology 19810619

Title: A new approach to the treatment of atherosclerosis and trapidil as an antagonist to platelet-derived growth factor.

Journal: Life sciences 19810406

Title: Effects of trapidil on thromboxane A2-induced aggregation of platelets, ischemic changes in heart and biosynthesis of thromboxane A2.

Journal: Prostaglandins and medicine 19810301

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SDS
Tags:15421-84-8 Molecular Formula|15421-84-8 MDL|15421-84-8 SMILES|15421-84-8 [1,2,4]Triazolo[1,5-a]pyrimidin-7-amine,N,N-diethyl-5-methyl-