Title: Identification, design and biological evaluation of bisaryl quinolones targeting Plasmodium falciparum type II NADH:quinone oxidoreductase (PfNDH2).
Journal: Journal of medicinal chemistry 20120308
Title: Identification, design and biological evaluation of heterocyclic quinolones targeting Plasmodium falciparum type II NADH:quinone oxidoreductase (PfNDH2).
Journal: Journal of medicinal chemistry 20120308
Title: Cucurbitacin E Induces G(2)/M Phase Arrest through STAT3/p53/p21 Signaling and Provokes Apoptosis via Fas/CD95 and Mitochondria-Dependent Pathways in Human Bladder Cancer T24 Cells.
Journal: Evidence-based complementary and alternative medicine : eCAM 20120101
Title: Solanum lyratum Extracts Induce Extrinsic and Intrinsic Pathways of Apoptosis in WEHI-3 Murine Leukemia Cells and Inhibit Allograft Tumor.
Journal: Evidence-based complementary and alternative medicine : eCAM 20120101
Title: CHM-1 induces apoptosis via p38-mediated upregulation of DR5 expression in human ovarian cancer SKOV3 cells.
Journal: European journal of pharmacology 20111116
Title: Specific microtubule-depolymerizing agents augment efficacy of dendritic cell-based cancer vaccines.
Journal: Journal of biomedical science 20110101
Title: Design, synthesis, and preclinical evaluation of new 5,6- (or 6,7-) disubstituted-2-(fluorophenyl)quinolin-4-one derivatives as potent antitumor agents.
Journal: Journal of medicinal chemistry 20101125
Title: The quinolone derivative CHM-1 inhibits murine WEHI-3 leukemia in BALB/c mice in vivo.
Journal: Leukemia & lymphoma 20101101
Title: The novel quinolone CHM-1 induces DNA damage and inhibits DNA repair gene expressions in a human osterogenic sarcoma cell line.
Journal: Anticancer research 20101001
Title: Discovery and development of natural product-derived chemotherapeutic agents based on a medicinal chemistry approach.
Journal: Journal of natural products 20100326
Title: Synthesis and preclinical evaluations of 2-(2-fluorophenyl)-6,7-methylenedioxyquinolin-4-one monosodium phosphate (CHM-1-P-Na) as a potent antitumor agent.
Journal: Journal of medicinal chemistry 20100225
Title: CHM-1, a new vascular targeting agent, induces apoptosis of human umbilical vein endothelial cells via p53-mediated death receptor 5 up-regulation.
Journal: The Journal of biological chemistry 20100219
Title: Cytotoxicity of apigenin on leukemia cell lines: implications for prevention and therapy.
Journal: Cell death & disease 20100101
Title: Novel quinolone CHM-1 induces apoptosis and inhibits metastasis in a human osterogenic sarcoma cell line.
Journal: Journal of orthopaedic research : official publication of the Orthopaedic Research Society 20091201
Title: Design and synthesis of 2-(3-benzo[b]thienyl)-6,7-methylenedioxyquinolin-4-one analogues as potent antitumor agents that inhibit tubulin assembly.
Journal: Journal of medicinal chemistry 20090813
Title: The synthesized 2-(2-fluorophenyl)-6,7-methylenedioxyquinolin-4-one (CHM-1) promoted G2/M arrest through inhibition of CDK1 and induced apoptosis through the mitochondrial-dependent pathway in CT-26 murine colorectal adenocarcinoma cells.
Journal: Journal of gastroenterology 20090101
Title: CHM-1, a novel synthetic quinolone with potent and selective antimitotic antitumor activity against human hepatocellular carcinoma in vitro and in vivo.
Journal: Molecular cancer therapeutics 20080201
Title: CHM-1 inhibits hepatocyte growth factor-induced invasion of SK-Hep-1 human hepatocellular carcinoma cells by suppressing matrix metalloproteinase-9 expression.
Journal: Cancer letters 20071108
Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.
Journal: The Journal of biological chemistry 20020419
Title: Antitumor Agents. 211. Fluorinated 2-phenyl-4-quinolone derivatives as antimitotic antitumor agents.
Journal: Journal of medicinal chemistry 20011108
