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Home Fluorides 1546-78-7
1546-78-7,MFCD00192530
Catalog No.:AA0037N1

1546-78-7 | 4-Hydroxy-6-(trifluoromethyl)pyrimidine

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1g
97%
in stock  
$11.00   $8.00
- +
5g
97%
in stock  
$27.00   $19.00
- +
10g
97%
in stock  
$33.00   $23.00
- +
100g
97%
in stock  
$306.00   $214.00
- +
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA0037N1
Chemical Name:
4-Hydroxy-6-(trifluoromethyl)pyrimidine
CAS Number:
1546-78-7
Molecular Formula:
C5H3F3N2O
Molecular Weight:
164.0853
MDL Number:
MFCD00192530
SMILES:
FC(c1ncnc(c1)O)(F)F
Properties
Properties
 
BP:
229°C at 760 mmHg  
Form:
Solid  
MP:
169-171 °C(lit.)  
Storage:
Keep in dry area;Room Temperature;  

Computed Properties
 
Complexity:
241  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
11  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
1  
XLogP3:
0.2  

Upstream Synthesis Route

[1]Patent:WO2007/75650,2007,A2,.Locationinpatent:Page/Pagecolumn43

[2]Patent:US2015/197511,2015,A1,

[3]Patent:WO2007/119055,2007,A1,

[1]Patent:WO2014/418,2014,A1,.Locationinpatent:Page/Pagecolumn84

[1]JournaloftheAmericanChemicalSociety,1958,vol.80,p.5744,5751

[1]Patent:US2006/4018,2006,A1,.Locationinpatent:Page/Pagecolumn39-40

[2]Patent:US2005/209241,2005,A1,.Locationinpatent:Page/Pagecolumn26

[3]Patent:WO2015/17335,2015,A1,.Locationinpatent:Page/Pagecolumn66

[4]Patent:US2015/197511,2015,A1,.Locationinpatent:Paragraph0393;0394

[5]Patent:WO2015/160654,2015,A1,.Locationinpatent:Page/Pagecolumn144-145

[6]Patent:CN106188013,2016,A,.Locationinpatent:Paragraph0014;0015;0019

[7]Patent:WO2007/119055,2007,A1,.Locationinpatent:Page/Pagecolumn37

[1]EuropeanJournalofOrganicChemistry,2006,#6,p.1593-1598

[2]Patent:WO2010/134478,2010,A1,.Locationinpatent:Page/Pagecolumn147

Downstream Synthesis Route

[1]JournaloftheAmericanChemicalSociety,1958,vol.80,p.5744,5751

[1]EuropeanJournalofOrganicChemistry,2004,p.3714-3718

[2]JournaloftheAmericanChemicalSociety,1958,vol.80,p.5744,5751

1546-78-7    77227-81-7   
3-(2,6-dichloro-4-trifluoromethyl-phenyl)-6-trifluoromethyl-3<i>H</i>-pyrimidin-4-one 

[1]Crowley,PatrickJ.;Mitchell,Glynn;Salmon,Roger;Worthington,PaulA.[Chimia,2004,vol.58,#3,p.138-142]

[1]BioorganicandMedicinalChemistryLetters,2005,vol.15,p.3632-3636

[1]EuropeanJournalofOrganicChemistry,2006,p.1593-1598

[2]Patent:WO2010/134478,2010,A1.Locationinpatent:Page/Pagecolumn147

Literature

Title: Substituted benzylamino-6-(trifluoromethyl)pyrimidin-4(1H)-ones: a novel class of selective human A-FABP inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20040906

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SDS
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