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156-51-4,MFCD00050687
Catalog No.:AA001OCB

156-51-4 | Hydrazine, (2-phenylethyl)-, sulfate (1:1)

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250mg
≥98%
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$116.00   $81.00
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500mg
≥98%
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$172.00   $120.00
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1g
98%
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$218.00   $153.00
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5g
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25g
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA001OCB
Chemical Name:
Hydrazine, (2-phenylethyl)-, sulfate (1:1)
CAS Number:
156-51-4
Molecular Formula:
C8H14N2O4S
Molecular Weight:
234.2728
MDL Number:
MFCD00050687
SMILES:
OS(=O)(=O)O.NNCCc1ccccc1
Properties
Properties
 
Form:
Solid  
MP:
157-161°C  

Computed Properties
 
Complexity:
159  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
15  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
3  

Downstream Synthesis Route
156-51-4   
CASUnavailable 
  61781-16-6 

[1]Neidlein,R.;Ober,W.-D.[MonatsheftefurChemie,1976,vol.107,p.1251-1258]

156-51-4   
CASUnavailable 
 
CASUnavailable 

[1]Or,YatSun;Clark,RichardF.;Xie,Qinghua;McAlpine,James;Whittern,DavidN.;etal.[Tetrahedron,1993,vol.49,#39,p.8771-8786]

156-51-4    237421-80-6   
CASUnavailable 

[1]Steger,Matthias;Young,DouglasW.[Tetrahedron,1999,vol.55,#25,p.7935-7956]

[1]CurrentPatentAssignee:PFIZERINC-WO2004/69245,2004,A1Locationinpatent:Page/Pagecolumn140-141

[1]CurrentPatentAssignee:NISSANCHEMICALCORPORATION-US5721264,1998,A

Literature

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Title: The MAO inhibitor phenelzine improves functional outcomes in mice with experimental autoimmune encephalomyelitis (EAE).

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Title: Modulation of dopaminergic neurotransmission in rat striatum upon in vitro and in vivo diclofenac treatment.

Journal: Journal of neurochemistry 20080401

Title: Phenelzine causes an increase in brain ornithine that is prevented by prior monoamine oxidase inhibition.

Journal: Neurochemical research 20080301

Title: Acute myocarditis after massive phenelzine overdose.

Journal: European journal of clinical pharmacology 20071101

Title: The monoamine oxidase inhibitor phenelzine enhances the discriminative stimulus effect of nicotine in rats.

Journal: Behavioural pharmacology 20071101

Title: Not all monoamine oxidase inhibitors are created equal.

Journal: Journal of the American Geriatrics Society 20071101

Title: Efficacy and safety of antidepressant monotherapy in the treatment of bipolar-II depression.

Journal: International clinical psychopharmacology 20070901

Title: Amine oxidases and their inhibitors: what can they tell us about neuroprotection and the development of drugs for neuropsychiatric disorders?

Journal: Journal of psychiatry & neuroscience : JPN 20070901

Title: Lithium augmentation compared with phenelzine in treatment-resistant depression in the elderly: an open, randomized, controlled trial.

Journal: The Journal of clinical psychiatry 20070801

Title: Treating DSM-IV depression with atypical features.

Journal: The Journal of clinical psychiatry 20070401

Title: Successful use of phenelzine in treatment-resistant panic disorder.

Journal: The Journal of clinical psychiatry 20070201

Title: Evolution of the clock from yeast to man by period-doubling folds in the cellular oscillator.

Journal: Cold Spring Harbor symposia on quantitative biology 20070101

Title: Serotonin syndrome from the interaction of cyclobenzaprine with other serotoninergic drugs.

Journal: Anesthesia and analgesia 20061201

Title: Aldehyde load in ischemia-reperfusion brain injury: neuroprotection by neutralization of reactive aldehydes with phenelzine.

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Journal: Pharmacology, biochemistry, and behavior 20061101

Title: Sustained effects of phenelzine and tranylcypromine on orthostatic challenge in antidepressant-refractory depression.

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Title: Tamoxifen protect against hydroxyl radical generation induced by phenelzine in rat striatum.

Journal: Toxicology 20060501

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

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Journal: CNS spectrums 20060501

Title: Transdermal selegiline: the new generation of monoamine oxidase inhibitors.

Journal: CNS spectrums 20060501

Title: An evaluation of potential mechanism-based inactivation of human drug metabolizing cytochromes P450 by monoamine oxidase inhibitors, including isoniazid.

Journal: British journal of clinical pharmacology 20060501

Title: Quetiapine for insomnia associated with refractory depression exacerbated by phenelzine.

Journal: The Annals of pharmacotherapy 20060301

Title: Treatment of depression with atypical features: a meta-analytic approach.

Journal: Psychiatry research 20060130

Title: Antidepressants reverse corticosterone-mediated decrease in brain-derived neurotrophic factor expression: differential regulation of specific exons by antidepressants and corticosterone.

Journal: Neuroscience 20060101

Title: Screening antidepressants in the chick separation-stress paradigm.

Journal: Psychopharmacology 20050801

Title: Inhibition of monoamine oxidase-A activity in rat brain by synthetic hydrazines: structure-activity relationship (SAR).

Journal: Journal of enzyme inhibition and medicinal chemistry 20050601

Title: Chronic treatment with the monoamine oxidase inhibitor phenelzine increases hypothalamic-pituitary-adrenocortical activity in male C57BL/6 mice: relevance to atypical depression.

Journal: Endocrinology 20050301

Title: Validity of sudden gains in acute phase treatment of depression.

Journal: Journal of consulting and clinical psychology 20050201

Title: Brainstem levels of transcription factor AP-2 in rat are changed after treatment with phenelzine, but not with citalopram.

Journal: BMC pharmacology 20050101

Title: Shy-Drager syndrome: multisystem atrophy with comorbid depression.

Journal: Psychosomatics 20050101

Title: In vivo evidence for reduced cortical glutamate-glutamine cycling in rats treated with the antidepressant/antipanic drug phenelzine.

Journal: Neuroscience 20050101

Title: Efficacy and tolerability of tranylcypromine versus phenelzine: a double-blind study in antidepressant-refractory depressed inpatients.

Journal: The Journal of clinical psychiatry 20041101

Title: Effect of antidepressants on GABA(B) receptor function and subunit expression in rat hippocampus.

Journal: Biochemical pharmacology 20041015

Title: Modafinil augmentation of phenelzine for residual fatigue in dysthymia.

Journal: The American journal of psychiatry 20040901

Title: Coadministration of phenelzine and methylphenidate for treatment-resistant depression.

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Title: Antioxidant effect of phenelzine on MPP+-induced cell viability loss in differentiated PC12 cells.

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Title: Comparing depression treatments.

Journal: The American journal of psychiatry 20030601

Title: Rapid tryptophan depletion reverses phenelzine-induced suppression of REM sleep.

Journal: Journal of sleep research 20030301

Title: Prior exposure to the elevated plus-maze sensitizes mice to the acute behavioral effects of fluoxetine and phenelzine.

Journal: European journal of pharmacology 20030117

Title: Phenelzine efficacy in refractory social anxiety disorder: a case series.

Journal: Nordic journal of psychiatry 20030101

Title: Pharmacological treatment of social anxiety disorder: a meta-analysis.

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Title: Phenelzine treatment increases transcription factor AP-2 levels in rat brain.

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Title: Different effects of phenelzine treatment on EEG topography in waking and sleep in depressed patients.

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Title: Remission in major depressive disorder: a comparison of pharmacotherapy, psychotherapy, and control conditions.

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Title: Clonidine potentiates the effects of tranylcypromine, phenelzine and two analogues in the forced swimming test in mice.

Journal: Journal of psychiatry & neuroscience : JPN 20020501

Title: Effects of the antidepressant/antipanic drug phenelzine and its putative metabolite phenylethylidenehydrazine on extracellular gamma-aminobutyric acid levels in the striatum.

Journal: Biochemical pharmacology 20020101

Title: The management of panic disorder.

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Title: Effect of chronic phenelzine treatment on REM sleep: report of three patients.

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Title: Effects of the antidepressant/antipanic drug phenelzine on alanine and alanine transaminase in rat brain.

Journal: Cellular and molecular neurobiology 20010801

Title: Common effects of chronically administered antipanic drugs on brainstem GABA(A) receptor subunit gene expression.

Journal: Molecular psychiatry 20010701

Title: The role of dopamine-metabolizing enzymes in the regulation of renal sodium excretion in the rat.

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Title: Application of capillary electrophoresis with laser-induced fluorescence detection to the determination of biogenic amines and amino acids in brain microdialysate and homogenate samples.

Journal: Journal of chromatography. A 20010420

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Title: Sleep and sleep electroencephalogram in depressed patients treated with phenelzine.

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Title: Treatment of social phobia with antidepressants.

Journal: The Journal of clinical psychiatry 20010101

Title: Nonresponse to first-line pharmacotherapy may predict relapse and recurrence of remitted geriatric depression.

Journal: Depression and anxiety 20010101

Title: Changes in vesicular monoamine transporter (VMAT2) and synaptophysin in rat Substantia nigra and prefrontal cortex induced by psychotropic drugs.

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Journal: Revue medicale de Liege 19991201

Title: Seizures in a diabetic patient on monoamine oxidase inhibitors.

Journal: The American journal of emergency medicine 19990101

Title: Phenelzine-induced sexual dysfunction treated with sildenafil.

Journal: Journal of sex & marital therapy 19990101

Title: Serotonin syndrome induced by transitioning from phenelzine to venlafaxine: four patient reports.

Journal: Neurology 19980701

Title: Stroke resulting from a rapid switch from phenelzine to tranylcypromine.

Journal: The Journal of clinical psychiatry 19980701

Title: Serotonin syndrome secondary to phenelzine-venlafaxine interaction.

Journal: Pharmacotherapy 19980101

Title: Seizure resulting from a venlafaxine overdose.

Journal: The Annals of pharmacotherapy 19970201

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Journal: The British journal of psychiatry : the journal of mental science 19950901

Title: Phenelzine and venlafaxine interaction.

Journal: The American journal of psychiatry 19950901

Title: Monoamine oxidase inhibitors and sleep movements.

Journal: The American journal of psychiatry 19940501

Title: Dose-related visual hallucinations in macular degeneration patients receiving phenelzine.

Journal: The American journal of psychiatry 19940301

Title: Hypertensive episode associated with phenelzine and tap beer--a reanalysis of the role of pressor amines in beer.

Journal: Journal of clinical psychopharmacology 19940201

Title: Depression after cyproheptadine: MAO treatment.

Journal: Biological psychiatry 19920601

Title: Possible interaction between an MAOI and 'ecstasy'.

Journal: The American journal of psychiatry 19920301

Title: The antidepressants fluoxetine, idazoxan and phenelzine alter corticotropin-releasing hormone and tyrosine hydroxylase mRNA levels in rat brain: therapeutic implications.

Journal: Brain research 19920214

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Journal: The American journal of drug and alcohol abuse 19920101

Title: Action of hydrazine drugs in tumor-free and 1,2-dimethylhydrazine-treated male rats.

Journal: Oncology research 19920101

Title: Phenelzine associated peripheral neuropathy--clinical and electrophysiologic findings.

Journal: Australian and New Zealand journal of medicine 19910601

Title: Outcome and clinical course in inpatient bulimic women: a 2- to 9-year follow-up study.

Journal: The Journal of clinical psychiatry 19910601

Title: Delayed excitatory reaction following interaction of cocaine and monoamine oxidase inhibitor (phenelzine).

Journal: British journal of anaesthesia 19910401

Title: Drug interaction.

Journal: Hospital & community psychiatry 19900701

Title: Case of delirium secondary to phenelzine/L-tryptophan combination.

Journal: The Journal of clinical psychiatry 19900701

Title: Adverse consequences of fluoxetine-MAOI combination therapy.

Journal: The Journal of clinical psychiatry 19900601

Title: Acute dystonic reaction induced by a monoamine oxidase inhibitor.

Journal: Journal of clinical psychopharmacology 19900401

Title: MAOI-induced hypersomnia in patients with bulimia.

Journal: The American journal of psychiatry 19890801

Title: Phenelzine-associated inappropriate ADH secretion.

Journal: Journal of clinical psychopharmacology 19890801

Title: The effects of mood changes and antidepressants on the cognitive capacity of elderly depressed patients.

Journal: International psychogeriatrics 19890101

Title: Common side effects associated with monoamine oxidase inhibitors.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 19890101

Title: Mania associated with high percentage of inhibition of monoamine oxidase.

Journal: The American journal of psychiatry 19890101

Title: Bradycardia induced by an interaction between phenelzine and beta blockers.

Journal: Psychosomatics 19890101

Title: Severe daytime somnolence in patients treated with an MAOI.

Journal: The American journal of psychiatry 19881201

Title: Drug-induced catatonia.

Journal: Canadian journal of psychiatry. Revue canadienne de psychiatrie 19881001

Title: Phenelzine vs placebo in 50 patients with bulimia.

Journal: Archives of general psychiatry 19880501

Title: Sexual dysfunction related to alprazolam treatment of social phobia.

Journal: The American journal of psychiatry 19880401

Title: Is monoamine oxidase inhibitor induced myoclonus serotoninergically mediated?

Journal: Journal of neural transmission 19880101

Title: A placebo-controlled comparison of the effect of nortriptyline and phenelzine on orthostatic hypotension in elderly depressed patients.

Journal: Journal of clinical psychopharmacology 19871201

Title: Partial status epilepticus following single low dose of chlorimipramine in a patient on MAO-inhibitor treatment.

Journal: Clinical neuropharmacology 19871201

Title: Possible toxic interaction between cyproheptadine and phenelzine.

Journal: The American journal of psychiatry 19870901

Title: Myoclonus and episodic delirium associated with phenelzine: a case report.

Journal: The Journal of clinical psychiatry 19870801

Title: The Newcastle chronic depression study: results of a treatment regime.

Journal: International clinical psychopharmacology 19870701

Title: Spontaneous remission of MAOI-induced anorgasmia.

Journal: The American journal of psychiatry 19870601

Title: Hypomania related to phenelzine and isoetharine interaction in one patient.

Journal: The Journal of clinical psychiatry 19870401

Title: Anorgasmia caused by an MAOI.

Journal: The American journal of psychiatry 19870401

Title: Myoclonic seizures after abrupt withdrawal from phenelzine and alprazolam.

Journal: The Journal of nervous and mental disease 19870201

Title: Comparative efficacy and safety of MAOIs versus TCAs in treating depression in the elderly.

Journal: Biological psychiatry 19861001

Title: Phenelzine induced grand mal seizure.

Journal: The British journal of clinical practice 19860401

Title: Parkinsonism induced by a monoamine oxidase inhibitor.

Journal: Postgraduate medical journal 19860301

Title: Urinary amine metabolite excretion in a patient with adrenergic hyperactivity state: reaction to phenelzine withdrawal and combined treatment.

Journal: The Journal of clinical psychiatry 19860201

Title: Two cases of hypomania following the addition of L-tryptophan to a monoamine oxidase inhibitor.

Journal: The American journal of psychiatry 19851201

Title: Myoclonus, hyperreflexia and diaphoresis in patients on phenelzine-tryptophan combination treatment.

Journal: Canadian journal of psychiatry. Revue canadienne de psychiatrie 19851001

Title: Phenelzine-induced hypomania: effect of verapamil.

Journal: Biological psychiatry 19850901

Title: Toxic reactions to the combination of monoamine oxidase inhibitors and tryptophan.

Journal: The American journal of psychiatry 19850401

Title: Adverse reactions to monoamine oxidase inhibitors. Part II. Treatment correlates and clinical management.

Journal: Journal of clinical psychopharmacology 19850201

Title: Acute psychosis following phenelzine discontinuation.

Journal: Journal of clinical psychopharmacology 19850201

Title: Possible interaction between pheneizine and amantadine.

Journal: Archives of general psychiatry 19840701

Title: Epilepsy as an adverse reaction to combined therapy of MAOIs and tricyclics.

Journal: Journal of the Royal Society of Medicine 19840401

Title: Case report of a toxic reaction from a combination of tryptophan and phenelzine.

Journal: The American journal of psychiatry 19840201

Title: The treatment of phenelzine-induced hypotension with salt tablets: case report.

Journal: The Journal of clinical psychiatry 19840201

Title: Parkinsonian side effects induced by a monoamine oxidase inhibitor.

Journal: The American journal of psychiatry 19840101

Title: MAOIs, anorgasmia, and weight gain.

Journal: The American journal of psychiatry 19830901

Title: Adverse reactions to abrupt discontinuation of phenelzine.

Journal: Journal of clinical psychopharmacology 19830601

Title: Pure motor hemiplegia associated with phenelzine use.

Journal: IMJ. Illinois medical journal 19830401

Title: Anorgasmia caused by MAOIs.

Journal: The American journal of psychiatry 19830401

Title: Interaction of phenelzine and sulfisoxazole.

Journal: The American journal of psychiatry 19830201

Title: More cases of anorgasmia after MAOI treatment.

Journal: The American journal of psychiatry 19830201

Title: Combination monoamine oxidase inhibitor/tricyclic antidepressants interaction.

Journal: Lancet (London, England) 19820821

Title: Cardiovascular effects of phenelzine and amitriptyline in depressed outpatients.

Journal: The Journal of clinical psychiatry 19820501

Title: Selective and nonselective monoamine oxidase inhibitors: behavioral disturbances during their administration to depressed patients.

Journal: Archives of general psychiatry 19820501

Title: MAOI-induced rapid cycling bipolar affective disorder in an adolescent.

Journal: The American journal of psychiatry 19810501

Title: Ejaculatory impairment from both phenelzine and imipramine, with tinnitus from phenelzine.

Journal: Journal of clinical psychopharmacology 19810501

Title: Angiosarcoma of liver associated with phenelzine.

Journal: British medical journal 19790623

Title: Clinical consequences of polymorphic acetylation of basic drugs.

Journal: Clinical pharmacology and therapeutics 19770901

Title: Pharmacological and biochemical studies with three metabolites of nomifensine.

Journal: Psychopharmacology 19770131

Title: Tumorigenicity of beta-phenylethylhydrazine sulfate in mice.

Journal: Cancer research 19760301

Title: Letter: Withdrawal symptoms after stopping phenelzine?

Journal: British medical journal 19740511

Title: A study of refractory cases of depressive illnesses and their response to combined antidepressant treatment.

Journal: The British journal of psychiatry : the journal of mental science 19740301

Title: The mechanism of the potentiating effect of antidepressant drugs on the protective influenc oe of diphenhydramine in experimental catatonia. The role of histamine.

Journal: Pharmacology 19740101

Title: Adverse reactions to phenelzine: results of a nine-hospital depression study.

Journal: The Journal of clinical pharmacology and new drugs 19720101

Title: Treatment of intractable narcolepsy with a monoamine oxidase inhibitor.

Journal: The New England journal of medicine 19711028

Title: Tricyclic antidepressants and monoamine oxidase inhibitors.

Journal: Archives of general psychiatry 19710601

Title: Monoamine oxidase inhibitors and L-dopa.

Journal: British medical journal 19700815

Title: Low serum pseudocholinesterase levels complicating treatment with phenelzine.

Journal: British medical journal 19690830

Title: 'Cold' cures and monoamine-oxidase inhibitors.

Journal: British medical journal 19690329

Title: Hypertension from cold remedies.

Journal: British medical journal 19690329

Title: Effects of a hydrazine monoamine oxidase inhibitor (phenelzine) on isoproterenol-induced myocardiopathies in the rat.

Journal: The Journal of pharmacology and experimental therapeutics 19670901

Title: Effect of certain monoamine oxidase inhibitors on isoproterenol-induced cardiac necrosis in rats.

Journal: Proceedings of the Western Pharmacology Society 19660101

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SDS
Tags:156-51-4 Molecular Formula|156-51-4 MDL|156-51-4 SMILES|156-51-4 Hydrazine, (2-phenylethyl)-, sulfate (1:1)