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156137-99-4,MFCD00870871
Catalog No.:AA00AD83

156137-99-4 | Rapacuronium

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5mg
98%
1 week  
$606.00   $424.00
- +
10mg
98%
1 week  
$924.00   $647.00
- +
25mg
98%
1 week  
$1,797.00   $1,258.00
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50mg
98%
1 week  
$2,590.00   $1,813.00
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100mg
98%
1 week  
$4,177.00   $2,924.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00AD83
Chemical Name:
Rapacuronium
CAS Number:
156137-99-4
Molecular Formula:
C37H61BrN2O4
Molecular Weight:
677.7952
MDL Number:
MFCD00870871
SMILES:
C=CC[N+]1(CCCCC1)[C@H]1C[C@@H]2[C@]([C@H]1OC(=O)CC)(C)CC[C@H]1[C@H]2CC[C@@H]2[C@]1(C)C[C@@H]([C@H](C2)OC(=O)C)N1CCCCC1.[Br-]
Properties
Computed Properties
 
Complexity:
1030  
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
10  
Heavy Atom Count:
44  
Hydrogen Bond Acceptor Count:
6  
Rotatable Bond Count:
9  

Literature

Title: Determining the potency of neuromuscular blockers: are traditional methods flawed?

Journal: British journal of anaesthesia 20100601

Title: Gantacurium and CW002 do not potentiate muscarinic receptor-mediated airway smooth muscle constriction in guinea pigs.

Journal: Anesthesiology 20100401

Title: Divergence of allosteric effects of rapacuronium on binding and function of muscarinic receptors.

Journal: BMC pharmacology 20090101

Title: Performance of an iterative two-stage bayesian technique for population pharmacokinetic analysis of rich data sets.

Journal: Pharmaceutical research 20061201

Title: Rapacuronium augments acetylcholine-induced bronchoconstriction via positive allosteric interactions at the M3 muscarinic receptor.

Journal: Anesthesiology 20051201

Title: Antiemetics of the 5-hydroxytryptamine 3A antagonist class inhibit muscle nicotinic acetylcholine receptors.

Journal: Anesthesia and analgesia 20050901

Title: Rapacuronium preferentially antagonizes the function of M2 versus M3 muscarinic receptors in guinea pig airway smooth muscle.

Journal: Anesthesiology 20050101

Title: Edrophonium effectively antagonizes neuromuscular block at the laryngeal adductors induced by rapacuronium, rocuronium and cisatracurium, but not mivacurium.

Journal: Canadian journal of anaesthesia = Journal canadien d'anesthesie 20031101

Title: [The time-course of action of rapacuronium and mivacurium after early reversal following equally lasting relaxation].

Journal: Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS 20030901

Title: A mechanism for rapacuronium-induced bronchospasm: M2 muscarinic receptor antagonism.

Journal: Anesthesiology 20030401

Title: Rapacuronium: premarket drug evaluation can be very effective for the identification of drug risks.

Journal: Anesthesia and analgesia 20030201

Title: Does the choice of intravenous induction drug affect intubation conditions after a fast-onset neuromuscular blocker?

Journal: Journal of clinical anesthesia 20030201

Title: Priming rapacuronium: a comparison with rocuronium and mivacurium.

Journal: Acta cientifica venezolana 20030101

Title: Neuromuscular effects of rapacuronium on the diaphragm and skeletal muscles in anaesthetized patients using cervical magnetic stimulation for stimulating the phrenic nerves.

Journal: European journal of anaesthesiology 20021201

Title: Effect of maintenance bolus on the recovery profile of a short-acting nondepolarizing muscle relaxant.

Journal: Journal of clinical anesthesia 20021101

Title: Further comments on the withdrawal of rapacuronium.

Journal: Anesthesia and analgesia 20021001

Title: The effect on lung mechanics in anesthetized children with rapacuronium: a comparative study with mivacurium.

Journal: Anesthesia and analgesia 20020701

Title: Another possible mechanism for bronchospasm after rapacuronium.

Journal: Anesthesiology 20020601

Title: Which formulation of propofol was used?

Journal: Anesthesiology 20020601

Title: The hemodynamic effects of rapacuronium in patients with coronary artery disease: succinylcholine and vecuronium compared.

Journal: Anesthesia and analgesia 20020501

Title: A comparison of neuromuscular effects, tracheal intubating conditions, and reversibility of rapacuronium versus mivacurium in female patients.

Journal: Anesthesia and analgesia 20020401

Title: Rapacuronium redux.

Journal: Anesthesia and analgesia 20020301

Title: Rapacuronium and the risk of bronchospasm in pediatric patients.

Journal: Anesthesia and analgesia 20020301

Title: The potency of new muscle relaxants on recombinant muscle-type acetylcholine receptors.

Journal: Anesthesia and analgesia 20020301

Title: Tracheal intubation conditions and cardiovascular effects after modified rapid-sequence induction with sevoflurane-rapacuronium versus propofol-rapacuronium.

Journal: Journal of clinical anesthesia 20020301

Title: Rapacuronium: why did it fail as a replacement for succinylcholine?

Journal: British journal of anaesthesia 20020201

Title: Prolongation of rapacuronium neuromuscular blockade by clindamycin and magnesium.

Journal: Anesthesia and analgesia 20020101

Title: Pharmacokinetics and pharmacodynamics of rapacuronium bromide.

Journal: Clinical pharmacokinetics 20020101

Title: [New muscle relaxants].

Journal: Masui. The Japanese journal of anesthesiology 20011201

Title: Rapacuronium for neuromuscular blockade in two myasthenic patients undergoing trans-sternal thymectomy.

Journal: European journal of anaesthesiology 20011101

Title: Use of rapacuronium in a child with spinal muscular atrophy.

Journal: Paediatric anaesthesia 20011101

Title: Reexamined: the recommended endotracheal intubating dose for nondepolarizing neuromuscular blockers of rapid onset.

Journal: Anesthesia and analgesia 20011001

Title: Effects of rapacuronium on respiratory function during general anesthesia: a comparison with cis-atracurium.

Journal: Anesthesiology 20011001

Title: A multicenter evaluation of the time-course of action of two doses of rapacuronium after early and late reversal with neostigmine.

Journal: Anesthesia and analgesia 20010801

Title: Rapacuronium administration to patients receiving phenytoin or carbamazepine.

Journal: Journal of neurosurgical anesthesiology 20010701

Title: Precipitation of thiopental by rapacuronium.

Journal: Anesthesiology 20010701

Title: Rapacuronium: an alternative to succinylcholine for electroconvulsive therapy.

Journal: Anesthesia and analgesia 20010501

Title: Duration of action of vecuronium after an intubating dose of rapacuronium, vecuronium, or succinylcholine.

Journal: Anesthesia and analgesia 20010501

Title: Rapacuronium and bronchospasm.

Journal: Anesthesiology 20010501

Title: Severe bronchospasm and desaturation in a child associated with rapacuronium.

Journal: Anesthesiology 20010501

Title: How serious is the bronchospasm induced by rapacuronium?

Journal: Anesthesiology 20010501

Title: Bronchospasm after rapacuronium in infants and children.

Journal: Anesthesiology 20010501

Title: No substitute for the intravenous route.

Journal: Anesthesiology 20010101

Title: Intramuscular rapacuronium in infants and children: a comparative multicenter study to confirm the efficacy and safety of the age-related tracheal intubating doses of intramuscular rapacuronium (ORG 9487) in two groups of pediatric subjects.

Journal: Anesthesiology 20010101

Title: Newer neuromuscular blocking agents: how do they compare with established agents?

Journal: Drugs 20010101

Title: 'Rap' in the streets: a retrospective look at the use of rapacuronium for prehospital rapid sequence induction.

Journal: Air medical journal 20010101

Title: Recent advances in myorelaxant therapy.

Journal: Paediatric anaesthesia 20010101

Title: Muscle relaxants in paediatric day case surgery.

Journal: European journal of anaesthesiology. Supplement 20010101

Title: Choice of the hypnotic and the opioid for rapid-sequence induction.

Journal: European journal of anaesthesiology. Supplement 20010101

Title: Choice of the muscle relaxant for rapid-sequence induction.

Journal: European journal of anaesthesiology. Supplement 20010101

Title: Rapacuronium: clinical pharmacology.

Journal: European journal of anaesthesiology. Supplement 20010101

Title: A pharmacokinetic-dynamic explanation of the rapid onset-offset of rapacuronium.

Journal: European journal of anaesthesiology. Supplement 20010101

Title: Rapacuronium: first experience in clinical practice.

Journal: European journal of anaesthesiology. Supplement 20010101

Title: Jakubík J, et al. Divergence of allosteric effects of Rapacuronium on binding and function of muscarinic receptors. BMC Pharmacol. 2009 Dec 28;9:15.

Title: Vizi ES, et al. A new short-acting non-depolarizing muscle relaxant (SZ1677) without cardiovascular side-effects. Acta Anaesthesiol Scand. 2003 Mar;47(3):291-300.

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