Home Amines 156886-85-0
156886-85-0
Catalog No.:AA00B8YT

156886-85-0 | N,N''-BIS[3-(ETHYLAMINO)PROPYL]PROPANE-1,3-DIAMINE TETRAHYDROCHLORIDE

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
98%
in stock  
$247.00   $173.00
- +
10mg
98%
in stock  
$349.00   $244.00
- +
25mg
98%
in stock  
$711.00   $498.00
- +
50mg
98%
in stock  
$1,275.00   $893.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00B8YT
Chemical Name:
N,N''-BIS[3-(ETHYLAMINO)PROPYL]PROPANE-1,3-DIAMINE TETRAHYDROCHLORIDE
CAS Number:
156886-85-0
Molecular Formula:
C13H36Cl4N4
Molecular Weight:
390.2637
SMILES:
CCNCCCNCCCNCCCNCC.Cl.Cl.Cl.Cl
Properties
Computed Properties
 
Complexity:
117  
Covalently-Bonded Unit Count:
5  
Heavy Atom Count:
21  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
8  
Rotatable Bond Count:
14  

Literature

Title: Overexpression of SSAT by DENSPM treatment induces cell detachment and apoptosis in glioblastoma.

Journal: Oncology reports 20120401

Title: Knockdown of ornithine decarboxylase antizyme 1 causes loss of uptake regulation leading to increased N1, N11-bis(ethyl)norspermine (BENSpm) accumulation and toxicity in NCI H157 lung cancer cells.

Journal: Amino acids 20120201

Title: Overexpression of spermidine/spermine N1-acetyltransferase or treatment with N1-N11-diethylnorspermine attenuates the severity of zinc-induced pancreatitis in mouse.

Journal: Amino acids 20120201

Title: Role of polyamines in determining the cellular response to chemotherapeutic agents: modulation of protein kinase CK2 expression and activity.

Journal: Molecular and cellular biochemistry 20111001

Title: Sulforaphane protects human chondrocytes against cell death induced by various stimuli.

Journal: Journal of cellular physiology 20110701

Title: Combination effects of platinum drugs and N1, N11 diethylnorspermine on spermidine/spermine N1-acetyltransferase, polyamines and growth inhibition in A2780 human ovarian carcinoma cells and their oxaliplatin and cisplatin-resistant variants.

Journal: Cancer chemotherapy and pharmacology 20110201

Title: Apoptosis induced by the potential chemotherapeutic drug N1, N11-Diethylnorspermine in a neuroblastoma cell line.

Journal: Anti-cancer drugs 20101101

Title: Bisethylnorspermine lipopolyamine as potential delivery vector for combination drug/gene anticancer therapies.

Journal: Pharmaceutical research 20100901

Title: The role of the polyamine catabolic enzymes SSAT and SMO in the synergistic effects of standard chemotherapeutic agents with a polyamine analogue in human breast cancer cell lines.

Journal: Cancer chemotherapy and pharmacology 20100501

Title: Spermidine/spermine N1-acetyltranferase modulation by novel folate cycle inhibitors in cisplatin-sensitive and -resistant human ovarian cancer cell lines.

Journal: Gynecologic oncology 20100501

Title: Spermine oxidase (SMO) activity in breast tumor tissues and biochemical analysis of the anticancer spermine analogues BENSpm and CPENSpm.

Journal: BMC cancer 20100101

Title: Spermine analogue-regulated expression of spermidine/spermine N1-acetyltransferase and its effects on depletion of intracellular polyamine pools in mouse fetal fibroblasts.

Journal: The Biochemical journal 20090815

Title: The polyamine analogue N1,N11-diethylnorspermine can induce chondrocyte apoptosis independently of its ability to alter metabolism and levels of natural polyamines.

Journal: Journal of cellular physiology 20090401

Title: Normal-like breast cells, but not breast cancer cells, recovered from treatment with N',N''-diethylnorspermine.

Journal: Anti-cancer drugs 20090401

Title: Effect of polyamine deficiency on proteins involved in Okazaki fragment maturation.

Journal: Cell biology international 20081201

Title: Molecular mechanisms underlying N1, N11-diethylnorspermine-induced apoptosis in a human breast cancer cell line.

Journal: Anti-cancer drugs 20081001

Title: Polyamine depletion with two different polyamine analogues causes DNA damage in human breast cancer cell lines.

Journal: DNA and cell biology 20080901

Title: Polyamine catabolism in colorectal cancer cells following treatment with oxaliplatin, 5-fluorouracil and N1, N11 diethylnorspermine.

Journal: Cancer chemotherapy and pharmacology 20080801

Title: Effect of the polyamine analogue N1,N11-diethylnorspermine on cell survival and susceptibility to apoptosis of human chondrocytes.

Journal: Journal of cellular physiology 20080701

Title: Different cell cycle kinetic effects of N1,N11-diethylnorspermine-induced polyamine depletion in four human breast cancer cell lines.

Journal: Anti-cancer drugs 20080401

Title: Subcellular distribution of spermidine/spermine N1-acetyltransferase.

Journal: Cell biology international 20080101

Title: Novel anti-apoptotic effect of Bcl-2: prevention of polyamine depletion-induced cell death.

Journal: Cell biology international 20080101

Title: Polyamine analogues bind human serum albumin.

Journal: Biomacromolecules 20071001

Title: Activation of polyamine catabolism by N1, N11-diethylnorspermine alters the cellular localization of mTOR and downregulates mTOR protein level in glioblastoma cells.

Journal: Cancer biology & therapy 20071001

Title: Polyamine-dependent regulation of spermidine-spermine N1-acetyltransferase mRNA translation.

Journal: The Journal of biological chemistry 20070928

Title: Activation of polyamine catabolism by N1,N11-diethylnorspermine leads to cell death in glioblastoma.

Journal: International journal of oncology 20070801

Title: Synergistic apoptosis of MCF-7 breast cancer cells by 2-methoxyestradiol and bis(ethyl)norspermine.

Journal: Cancer letters 20070608

Title: Inhibition of cell proliferation and induction of apoptosis by N(1),N(11)-diethylnorspermine-induced polyamine pool reduction.

Journal: Biochemical Society transactions 20070401

Title: The role of spermidine/spermine N1-acetyltransferase in determining response to chemotherapeutic agents in colorectal cancer cells.

Journal: Molecular cancer therapeutics 20070101

Title: Inactivation of IkappaB contributes to transcriptional activation of spermidine/spermine N(1)-acetyltransferase.

Journal: Molecular carcinogenesis 20060901

Title: Concentration-dependent effects of N1, N11-diethylnorspermine on melanoma cell proliferation.

Journal: International journal of cancer 20060115

Title: Potential usefulness of N1,N11-diethylnorspermine to prevent suicidal behaviour.

Journal: Medical hypotheses 20060101

Title: Mice with targeted disruption of spermidine/spermine N1-acetyltransferase gene maintain nearly normal tissue polyamine homeostasis but show signs of insulin resistance upon aging.

Journal: Journal of cellular and molecular medicine 20060101

Title: Spermine oxidase SMO(PAOh1), Not N1-acetylpolyamine oxidase PAO, is the primary source of cytotoxic H2O2 in polyamine analogue-treated human breast cancer cell lines.

Journal: The Journal of biological chemistry 20051202

Title: Mechanistic studies of mouse polyamine oxidase with N1,N12-bisethylspermine as a substrate.

Journal: Biochemistry 20050510

Title: Comparison of three cytotoxicity tests in the evaluation of the cytotoxicity of a spermine analogue on human breast cancer cell lines.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20050401

Title: Effects of N1, N13-diethylnorspermine (DENSPM) and X-radiation treatment on human colorectal tumor clones with varying X-radiation and drug responses.

Journal: Radiation research 20050401

Title: Combination of 5-fluorouracil and N1,N11-diethylnorspermine markedly activates spermidine/spermine N1-acetyltransferase expression, depletes polyamines, and synergistically induces apoptosis in colon carcinoma cells.

Journal: The Journal of biological chemistry 20050204

Title: Bis(ethyl)norspermine potentiates the apoptotic activity of the pure antiestrogen ICI 182780 in breast cancer cells.

Journal: Oncology reports 20050101

Title: Induction of spermidine/spermine N1-acetyltransferase in breast cancer tissues treated with the polyamine analogue N1, N11-diethylnorspermine.

Journal: Cancer chemotherapy and pharmacology 20040801

Title: Polyamine catabolism in platinum drug action: Interactions between oxaliplatin and the polyamine analogue N1,N11-diethylnorspermine at the level of spermidine/spermine N1-acetyltransferase.

Journal: Molecular cancer therapeutics 20040701

Title: A Phase II study of the polyamine analog N1,N11-diethylnorspermine (DENSpm) daily for five days every 21 days in patients with previously treated metastatic breast cancer.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20031201

Title: Loss of inhibitor of apoptosis proteins as a determinant of polyamine analog-induced apoptosis in human melanoma cells.

Journal: Oncogene 20030807

Title: The role of mitogen-activated protein kinase activation in determining cellular outcomes in polyamine analogue-treated human melanoma cells.

Journal: Cancer research 20030701

Title: Properties of the spermidine/spermine N1-acetyltransferase mutant L156F that decreases cellular sensitivity to the polyamine analogue N1, N11-bis(ethyl)norspermine.

Journal: The Journal of biological chemistry 20030418

Title: Phase I study of N(1),N(11)-diethylnorspermine in patients with non-small cell lung cancer.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20020301

Title: Concurrent overexpression of ornithine decarboxylase and spermidine/spermine N(1)-acetyltransferase further accelerates the catabolism of hepatic polyamines in transgenic mice.

Journal: The Biochemical journal 20010901

Title: Apoptotic signaling in polyamine analogue-treated SK-MEL-28 human melanoma cells.

Journal: Cancer research 20010901

Title: Spermine deficiency resulting from targeted disruption of the spermine synthase gene in embryonic stem cells leads to enhanced sensitivity to antiproliferative drugs.

Journal: Molecular pharmacology 20010201

Title: Phase 1 study of N1-N11-diethylnorspermine (DENSPM) administered TID for 6 days in patients with advanced malignancies.

Journal: Investigational new drugs 20010101

Title: Unusual central nervous system toxicity in a phase I study of N1N11 diethylnorspermine in patients with advanced malignancy.

Journal: Investigational new drugs 19970101

Title: Preclinical toxicologic evaluation of DENSPM (N1,N11-diethylnorspermine) in rats and dogs.

Journal: Anti-cancer drugs 19940801

Title: M Fogel-Petrovic, et al. Structural basis for differential induction of spermidine/spermine N1-acetyltransferase activity by novel spermine analogs. Mol Pharmacol. 1997 Jul;52(1):69-74.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Tags:156886-85-0 Molecular Formula|156886-85-0 MDL|156886-85-0 SMILES|156886-85-0 N,N''-BIS[3-(ETHYLAMINO)PROPYL]PROPANE-1,3-DIAMINE TETRAHYDROCHLORIDE