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Home Amines 1572414-83-5
1572414-83-5,MFCD28099817
Catalog No.:AA00ABI1

1572414-83-5 | 2-(2-Isopropylphenyl)-5-methyl-N-{[4-(1,2,3-triazol-1-yl)phenyl]methyl}pyrimidin-4-amine

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
98%
in stock  
$112.00   $78.00
- +
10mg
98%
in stock  
$164.00   $115.00
- +
25mg
95%
in stock  
$241.00   $169.00
- +
50mg
98%
in stock  
$259.00   $181.00
- +
1000mg
95
in stock  
$4,634.00   $3,244.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00ABI1
Chemical Name:
2-(2-Isopropylphenyl)-5-methyl-N-{[4-(1,2,3-triazol-1-yl)phenyl]methyl}pyrimidin-4-amine
CAS Number:
1572414-83-5
Molecular Formula:
C23H24N6
Molecular Weight:
384.4769
MDL Number:
MFCD28099817
SMILES:
Cc1cnc(nc1NCc1ccc(cc1)n1nncc1)c1ccccc1C(C)C
Properties
Computed Properties
 
Complexity:
492  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
6  
XLogP3:
4.6  

Literature

Title: Synthesis and structure-activity relationship studies of N-benzyl-2-phenylpyrimidin-4-amine derivatives as potent USP1/UAF1 deubiquitinase inhibitors with anticancer activity against nonsmall cell lung cancer.

Journal: Journal of medicinal chemistry 20141009

Title: Liang Q, et al. A selective USP1-UAF1 inhibitor links deubiquitination to DNA damage responses. Nat Chem Biol. 2014 Apr;10(4):298-304.

Title: Dexheimer TS, et al. Discovery of ML323 as a Novel Inhibitor of the USP1/UAF1 Deubiquitinase Complex. National Center for Biotechnology Information; 2010-2012 Oct 23.

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Tags:1572414-83-5 Molecular Formula|1572414-83-5 MDL|1572414-83-5 SMILES|1572414-83-5 2-(2-Isopropylphenyl)-5-methyl-N-{[4-(1,2,3-triazol-1-yl)phenyl]methyl}pyrimidin-4-amine