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157381-42-5,MFCD00672650
Catalog No.:AA001PBZ

157381-42-5 | L-Isovaline, 4-phosphono-

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10mg
≥96%(HPLC)
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$425.00   $298.00
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50mg
≥96%(HPLC)
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA001PBZ
Chemical Name:
L-Isovaline, 4-phosphono-
CAS Number:
157381-42-5
Molecular Formula:
C5H12NO5P
Molecular Weight:
197.1262
MDL Number:
MFCD00672650
SMILES:
OC(=O)[C@](CCP(=O)(O)O)(N)C
Properties
Computed Properties
 
Complexity:
224  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
12  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
4  
XLogP3:
-4.6  

Literature

Title: Structural evidence for cooperative microtubule stabilization by Taxol and the endogenous dynamics regulator MAP4.

Journal: ACS chemical biology 20120420

Title: Identification of a novel role of Septin 10 in paclitaxel-resistance in cancers through a functional genomics screen.

Journal: Cancer science 20120401

Title: Cytoskeletal role in protection of the failing heart by β-adrenergic blockade.

Journal: American journal of physiology. Heart and circulatory physiology 20120201

Title: Microtubule-associated protein 4 binds to actin filaments and modulates their properties.

Journal: Journal of biochemistry 20120101

Title: Microtubular stability affects pVHL-mediated regulation of HIF-1alpha via the p38/MAPK pathway in hypoxic cardiomyocytes.

Journal: PloS one 20120101

Title: Protective effects of flavonoid extract from Apocynum venetum leaves against corticosterone-induced neurotoxicity in PC12 cells.

Journal: Cellular and molecular neurobiology 20110401

Title: Strain response in fibroblasts indicates a possible role of the Ca(2+)-dependent nuclear transcription factor NM1 in RNA synthesis.

Journal: Cell calcium 20110401

Title: MAP4 mechanism that stabilizes mitochondrial permeability transition in hypoxia: microtubule enhancement and DYNLT1 interaction with VDAC1.

Journal: PloS one 20110101

Title: Distinct neuronal localization of microtubule-associated protein 4 in the mammalian brain.

Journal: Neuroscience letters 20101029

Title: Inhibition of cell migration and cell division correlates with distinct effects of microtubule inhibiting drugs.

Journal: The Journal of biological chemistry 20101015

Title: A central role for polyamines in microtubule assembly in cells.

Journal: The Biochemical journal 20100815

Title: Site-specific microtubule-associated protein 4 dephosphorylation causes microtubule network densification in pressure overload cardiac hypertrophy.

Journal: The Journal of biological chemistry 20100709

Title: Novel PSEN1 and PGRN mutations in early-onset familial frontotemporal dementia.

Journal: Neurobiology of aging 20091101

Title: Overexpression of class III beta-tubulin predicts good response to taxane-based chemotherapy in ovarian clear cell adenocarcinoma.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20090215

Title: Microtubule-dependent distribution of mRNA in adult cardiocytes.

Journal: American journal of physiology. Heart and circulatory physiology 20080301

Title: A MAP4 kinase related to Ste20 is a nutrient-sensitive regulator of mTOR signalling.

Journal: The Biochemical journal 20070401

Title: An isoform of microtubule-associated protein 4 inhibits kinesin-driven microtubule gliding.

Journal: Journal of biochemistry 20070401

Title: Developmental regulation of cardiac MAP4 protein expression.

Journal: Cell motility and the cytoskeleton 20060801

Title: The individualization of cancer therapy: the unexpected role of p53.

Journal: Transactions of the American Clinical and Climatological Association 20060101

Title: Inhibition of beta-adrenergic receptor trafficking in adult cardiocytes by MAP4 decoration of microtubules.

Journal: American journal of physiology. Heart and circulatory physiology 20050301

Title: Identification of a neural cell specific variant of microtubule-associated protein 4.

Journal: Cell structure and function 20050201

Title: Distinct roles of group III metabotropic glutamate receptors in control of nociception and dorsal horn neurons in normal and nerve-injured Rats.

Journal: The Journal of pharmacology and experimental therapeutics 20050101

Title: Encounters between dynamic cortical microtubules promote ordering of the cortical array through angle-dependent modifications of microtubule behavior.

Journal: The Plant cell 20041201

Title: MARK4 is a novel microtubule-associated proteins/microtubule affinity-regulating kinase that binds to the cellular microtubule network and to centrosomes.

Journal: The Journal of biological chemistry 20040213

Title: Up-regulation of microtubule-associated protein 4 and drebrin A mRNA expression by antidepressants in rat hippocampus following chronic stress.

Journal: Neuroscience letters 20031120

Title: The number of repeat sequences in microtubule-associated protein 4 affects the microtubule surface properties.

Journal: The Journal of biological chemistry 20030808

Title: Drug resistance associated with loss of p53 involves extensive alterations in microtubule composition and dynamics.

Journal: British journal of cancer 20030602

Title: Different protofilament-dependence of the microtubule binding between MAP2 and MAP4.

Journal: Biochemical and biophysical research communications 20030523

Title: Elevated levels of microtubule destabilizing factors in a Taxol-resistant/dependent A549 cell line with an alpha-tubulin mutation.

Journal: Cancer research 20030315

Title: Katanin-mediated microtubule severing can be regulated by multiple mechanisms.

Journal: Cell motility and the cytoskeleton 20021201

Title: Inhibition of G protein-coupled receptor trafficking in neuroblastoma cells by MAP 4 decoration of microtubules.

Journal: American journal of physiology. Heart and circulatory physiology 20021201

Title: The metabotropic glutamate receptors: structure, activation mechanism and pharmacology.

Journal: Current drug targets. CNS and neurological disorders 20020601

Title: A Phase I/pilot study of sequential doxorubicin/vinorelbine: effects on p53 and microtubule-associated protein 4.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20020501

Title: Multiple microtubule alterations are associated with Vinca alkaloid resistance in human leukemia cells.

Journal: Cancer research 20010801

Title: Phosphorylation of MAP4 affects microtubule properties and cell cycle progression.

Journal: Journal of cell science 20010801

Title: Adenovirus-mediated p16 gene transfer changes the sensitivity to taxanes and Vinca alkaloids of human ovarian cancer cells.

Journal: Anticancer research 20010101

Title: Binding of [3H](2S,1'S,2'S)-2-(9-xanthylmethyl)-2-(2'-carboxycyclopropyl) glycine ([3H]LY341495) to cell membranes expressing recombinant human group III metabotropic glutamate receptor subtypes.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20001201

Title: Constraints on proper folding of the amino terminal domains of group III metabotropic glutamate receptors.

Journal: Brain research. Molecular brain research 20000310

Title: Ligand binding to the amino-terminal domain of the mGluR4 subtype of metabotropic glutamate receptor.

Journal: The Journal of biological chemistry 19990409

Title: Cloning and expression of rat metabotropic glutamate receptor 8 reveals a distinct pharmacological profile.

Journal: Molecular pharmacology 19970101

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Tags:157381-42-5 Molecular Formula|157381-42-5 MDL|157381-42-5 SMILES|157381-42-5 L-Isovaline, 4-phosphono-